BRD-A55484088_BNTX maleate_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

217 genes differentially expressed following the BRD-A55484088_BNTX maleate_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAK1 AP2 associated kinase 1
ABHD4 abhydrolase domain containing 4
ADM adrenomedullin
AKAP17A A kinase (PRKA) anchor protein 17A
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ANKRD12 ankyrin repeat domain 12
ATF3 activating transcription factor 3
ATG101 autophagy related 101
BAG3 BCL2-associated athanogene 3
BMP2 bone morphogenetic protein 2
BRD2 bromodomain containing 2
BRD4 bromodomain containing 4
CADM1 cell adhesion molecule 1
CAPN2 calpain 2, (m/II) large subunit
CCL5 chemokine (C-C motif) ligand 5
CCNL1 cyclin L1
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL6A2 collagen, type VI, alpha 2
CYLD cylindromatosis (turban tumor syndrome)
DDIT3 DNA-damage-inducible transcript 3
DLX2 distal-less homeobox 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EZR ezrin
F3 coagulation factor III (thromboplastin, tissue factor)
FN1 fibronectin 1
FOSL2 FOS-like antigen 2
FTL ferritin, light polypeptide
GABARAPL1 GABA(A) receptor-associated protein like 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GATA6 GATA binding protein 6
GEM GTP binding protein overexpressed in skeletal muscle
HBEGF heparin-binding EGF-like growth factor
HCAR3 hydroxycarboxylic acid receptor 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGHD immunoglobulin heavy constant delta
IL10RA interleukin 10 receptor, alpha
ITCH itchy E3 ubiquitin protein ligase
JAG1 jagged 1
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
KCMF1 potassium channel modulatory factor 1
KCTD5 potassium channel tetramerization domain containing 5
KDM3A lysine (K)-specific demethylase 3A
KLF4 Kruppel-like factor 4 (gut)
KRT6A keratin 6A, type II
LBH limb bud and heart development
LCN2 lipocalin 2
LMO4 LIM domain only 4
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MICALL1 MICAL-like 1
MIR22HG MIR22 host gene
MYO10 myosin X
NDRG1 N-myc downstream regulated 1
NFIL3 nuclear factor, interleukin 3 regulated
OSER1 oxidative stress responsive serine-rich 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PDGFA platelet-derived growth factor alpha polypeptide
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PGC progastricsin (pepsinogen C)
PKP1 plakophilin 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RANBP2 RAN binding protein 2
RIOK3 RIO kinase 3
RIT1 Ras-like without CAAX 1
RLF rearranged L-myc fusion
RND3 Rho family GTPase 3
RNF19B ring finger protein 19B
RYBP RING1 and YY1 binding protein
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SFTPC surfactant protein C
SIK1 salt-inducible kinase 1
SMAD7 SMAD family member 7
SOWAHC sosondowah ankyrin repeat domain family member C
STX1A syntaxin 1A (brain)
STX3 syntaxin 3
TRIB1 tribbles pseudokinase 1
TUBA4A tubulin, alpha 4a
TUFT1 tuftelin 1
TXNRD1 thioredoxin reductase 1
UBR4 ubiquitin protein ligase E3 component n-recognin 4
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
YAP1 Yes-associated protein 1
ZBTB43 zinc finger and BTB domain containing 43
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ABLIM1 actin binding LIM protein 1
ADD3 adducin 3 (gamma)
APOD apolipoprotein D
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ARMT1 acidic residue methyltransferase 1
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
AURKA aurora kinase A
AZGP1 alpha-2-glycoprotein 1, zinc-binding
B3GNT1
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BHLHE41 basic helix-loop-helix family, member e41
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CA12 carbonic anhydrase XII
CCNA2 cyclin A2
CD36 CD36 molecule (thrombospondin receptor)
CDC20 cell division cycle 20
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CHRDL1 chordin-like 1
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CRABP2 cellular retinoic acid binding protein 2
CXCL12 chemokine (C-X-C motif) ligand 12
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DMD dystrophin
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUT deoxyuridine triphosphatase
EBP emopamil binding protein (sterol isomerase)
EIF5A eukaryotic translation initiation factor 5A
ESR1 estrogen receptor 1
FKBP3 FK506 binding protein 3, 25kDa
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GAS1 growth arrest-specific 1
GINS2 GINS complex subunit 2 (Psf2 homolog)
GTF3A general transcription factor IIIA
HADH hydroxyacyl-CoA dehydrogenase
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP4 insulin-like growth factor binding protein 4
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
ISOC1 isochorismatase domain containing 1
KIAA0101 KIAA0101
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LEPR leptin receptor
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIG1 ligase I, DNA, ATP-dependent
LIPA lipase A, lysosomal acid, cholesterol esterase
LXN latexin
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAGED2 melanoma antigen family D2
MAPT microtubule-associated protein tau
MARCKS myristoylated alanine-rich protein kinase C substrate
MFAP5 microfibrillar associated protein 5
MREG melanoregulin
MUC1 mucin 1, cell surface associated
MYB v-myb avian myeloblastosis viral oncogene homolog
NBN nibrin
NHP2 NHP2 ribonucleoprotein
OGN osteoglycin
OLFM1 olfactomedin 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PDGFRL platelet-derived growth factor receptor-like
PIP prolactin-induced protein
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PSENEN presenilin enhancer gamma secretase subunit
PTTG1 pituitary tumor-transforming 1
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RBM3 RNA binding motif (RNP1, RRM) protein 3
RET ret proto-oncogene
RFC3 replication factor C (activator 1) 3, 38kDa
RHOBTB3 Rho-related BTB domain containing 3
RRM2 ribonucleotide reductase M2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB1D2 secretoglobin, family 1D, member 2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPDEF SAM pointed domain containing ETS transcription factor
SRPX sushi-repeat containing protein, X-linked
STMN1 stathmin 1
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TFPI2 tissue factor pathway inhibitor 2
THBS1 thrombospondin 1
TMEM50A transmembrane protein 50A
TOP2A topoisomerase (DNA) II alpha 170kDa
TUBA1A tubulin, alpha 1a
TUBB tubulin, beta class I
TYMS thymidylate synthetase