BRD-A52650764_Ingenol 3, 20-dibenzoate_SKLU1_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

219 genes differentially expressed following the BRD-A52650764_Ingenol 3, 20-dibenzoate_SKLU1_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGFG1 ArfGAP with FG repeats 1
ALG13 ALG13, UDP-N-acetylglucosaminyltransferase subunit
AREG amphiregulin
ATF3 activating transcription factor 3
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
BMP2 bone morphogenetic protein 2
BTG1 B-cell translocation gene 1, anti-proliferative
CA2 carbonic anhydrase II
CALML5 calmodulin-like 5
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCL20 chemokine (C-C motif) ligand 20
CD47 CD47 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHIC2 cysteine-rich hydrophobic domain 2
CHMP2B charged multivesicular body protein 2B
CKB creatine kinase, brain
CLDN4 claudin 4
CPM carboxypeptidase M
CSTA cystatin A (stefin A)
CTSB cathepsin B
CTSK cathepsin K
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DPT dermatopontin
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EGR3 early growth response 3
EHD4 EH-domain containing 4
EXOSC4 exosome component 4
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM3C family with sequence similarity 3, member C
FOS FBJ murine osteosarcoma viral oncogene homolog
G0S2 G0/G1 switch 2
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GEM GTP binding protein overexpressed in skeletal muscle
GPX3 glutathione peroxidase 3
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HMOX1 heme oxygenase 1
IDS iduronate 2-sulfatase
IER2 immediate early response 2
IER3 immediate early response 3
IFI27 interferon, alpha-inducible protein 27
IL13RA2 interleukin 13 receptor, alpha 2
IL6 interleukin 6
IMPA1 inositol(myo)-1(or 4)-monophosphatase 1
INHBA inhibin, beta A
IQCG IQ motif containing G
ISG20 interferon stimulated exonuclease gene 20kDa
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JAG1 jagged 1
JUNB jun B proto-oncogene
KCTD5 potassium channel tetramerization domain containing 5
KDM7A lysine (K)-specific demethylase 7A
KLF4 Kruppel-like factor 4 (gut)
KRT1 keratin 1, type II
KRT14 keratin 14, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LGALS3 lectin, galactoside-binding, soluble, 3
LIF leukemia inhibitory factor
LMO4 LIM domain only 4
MIR22HG MIR22 host gene
MMP1 matrix metallopeptidase 1
MMP10 matrix metallopeptidase 10
MMP9 matrix metallopeptidase 9
MREG melanoregulin
MTSS1 metastasis suppressor 1
MYO10 myosin X
MYO1B myosin IB
NAMPT nicotinamide phosphoribosyltransferase
NDRG1 N-myc downstream regulated 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPC1 Niemann-Pick disease, type C1
ODC1 ornithine decarboxylase 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PI3 peptidase inhibitor 3, skin-derived
PLAT plasminogen activator, tissue
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLTP phospholipid transfer protein
PPAP2B phosphatidic acid phosphatase type 2B
PPIF peptidylprolyl isomerase F
PRKCD protein kinase C, delta
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTK2 protein tyrosine kinase 2
PTPN12 protein tyrosine phosphatase, non-receptor type 12
RAB22A RAB22A, member RAS oncogene family
RAB38 RAB38, member RAS oncogene family
RAB6A RAB6A, member RAS oncogene family
RAB9A RAB9A, member RAS oncogene family
REEP5 receptor accessory protein 5
RHCG Rh family, C glycoprotein
RHOB ras homolog family member B
RHOQ ras homolog family member Q
RIOK3 RIO kinase 3
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
S100A2 S100 calcium binding protein A2
SAT1 spermidine/spermine N1-acetyltransferase 1
SATB2 SATB homeobox 2
SERINC5 serine incorporator 5
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SERTAD2 SERTA domain containing 2
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC35F2 solute carrier family 35, member F2
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SMYD2 SET and MYND domain containing 2
SOX4 SRY (sex determining region Y)-box 4
SPHK1 sphingosine kinase 1
SPRR1B small proline-rich protein 1B
SRI sorcin
STC1 stanniocalcin 1
STK17A serine/threonine kinase 17a
SUB1 SUB1 homolog (S. cerevisiae)
TBPL1 TBP-like 1
TFPI2 tissue factor pathway inhibitor 2
TGFA transforming growth factor, alpha
TLR4 toll-like receptor 4
TNC tenascin C
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNIP1 TNFAIP3 interacting protein 1
TOMM34 translocase of outer mitochondrial membrane 34
TRIB1 tribbles pseudokinase 1
TXNDC9 thioredoxin domain containing 9
UBL3 ubiquitin-like 3
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ACTG2 actin, gamma 2, smooth muscle, enteric
ADIRF adipogenesis regulatory factor
ANG angiogenin, ribonuclease, RNase A family, 5
ARHGAP29 Rho GTPase activating protein 29
AZGP1 alpha-2-glycoprotein 1, zinc-binding
B3GNT1
BRCA1 breast cancer 1, early onset
C14ORF159 chromosome 14 open reading frame 159
C9ORF3 chromosome 9 open reading frame 3
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CDC25B cell division cycle 25B
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CENPA centromere protein A
CES1 carboxylesterase 1
COL1A2 collagen, type I, alpha 2
COL5A1 collagen, type V, alpha 1
COLEC12 collectin sub-family member 12
CXCL12 chemokine (C-X-C motif) ligand 12
DAPK1 death-associated protein kinase 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DES desmin
DKK3 dickkopf WNT signaling pathway inhibitor 3
EIF5A eukaryotic translation initiation factor 5A
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ERBB2 erb-b2 receptor tyrosine kinase 2
FLRT2 fibronectin leucine rich transmembrane protein 2
FZD2 frizzled class receptor 2
FZD7 frizzled class receptor 7
HAUS4 HAUS augmin-like complex, subunit 4
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
IFRD2 interferon-related developmental regulator 2
KIF20A kinesin family member 20A
MCM2 minichromosome maintenance complex component 2
MCM5 minichromosome maintenance complex component 5
MDFIC MyoD family inhibitor domain containing
MDK midkine (neurite growth-promoting factor 2)
MYRF myelin regulatory factor
NDC80 NDC80 kinetochore complex component
NNMT nicotinamide N-methyltransferase
NSF N-ethylmaleimide-sensitive factor
OXA1L oxidase (cytochrome c) assembly 1-like
PAN2 PAN2 poly(A) specific ribonuclease subunit
PBK PDZ binding kinase
PDGFA platelet-derived growth factor alpha polypeptide
PDLIM3 PDZ and LIM domain 3
PEG3 paternally expressed 3
PER3 period circadian clock 3
PIEZO2 piezo-type mechanosensitive ion channel component 2
PIR pirin (iron-binding nuclear protein)
PLAC8 placenta-specific 8
PLK1 polo-like kinase 1
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRC1 protein regulator of cytokinesis 1
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRUNE2 prune homolog 2 (Drosophila)
PTPRC protein tyrosine phosphatase, receptor type, C
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RELN reelin
RPS11 ribosomal protein S11
SCGB2A1 secretoglobin, family 2A, member 1
SHB Src homology 2 domain containing adaptor protein B
SLC12A8 solute carrier family 12, member 8
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLCO1B3 solute carrier organic anion transporter family, member 1B3
TDO2 tryptophan 2,3-dioxygenase
THBS1 thrombospondin 1
TMEM47 transmembrane protein 47
TMEM97 transmembrane protein 97
TNNT1 troponin T type 1 (skeletal, slow)
TPM1 tropomyosin 1 (alpha)
TPM2 tropomyosin 2 (beta)
UNC13B unc-13 homolog B (C. elegans)
USP1 ubiquitin specific peptidase 1
WNT5A wingless-type MMTV integration site family, member 5A
ZNF586 zinc finger protein 586