BRD-A52530684_DOXORUBICIN_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

311 genes differentially expressed following the BRD-A52530684_DOXORUBICIN_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABHD17A abhydrolase domain containing 17A
ACKR3 atypical chemokine receptor 3
ADAM9 ADAM metallopeptidase domain 9
AIDA axin interactor, dorsalization associated
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AQP1 aquaporin 1 (Colton blood group)
BCHE butyrylcholinesterase
BLNK B-cell linker
BSG basigin (Ok blood group)
CA2 carbonic anhydrase II
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCND2 cyclin D2
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CECR1 cat eye syndrome chromosome region, candidate 1
CETN2 centrin, EF-hand protein, 2
CFB complement factor B
CFD complement factor D (adipsin)
CKB creatine kinase, brain
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL4A5 collagen, type IV, alpha 5
CPE carboxypeptidase E
CPM carboxypeptidase M
CRP C-reactive protein, pentraxin-related
CTSV cathepsin V
CXADR coxsackie virus and adenovirus receptor
CYBB cytochrome b-245, beta polypeptide
EGFL6 EGF-like-domain, multiple 6
EIF5A eukaryotic translation initiation factor 5A
FBLN1 fibulin 1
FBN2 fibrillin 2
FGFR3 fibroblast growth factor receptor 3
FHL1 four and a half LIM domains 1
FXYD3 FXYD domain containing ion transport regulator 3
GDE1 glycerophosphodiester phosphodiesterase 1
GLUL glutamate-ammonia ligase
GM2A GM2 ganglioside activator
GPC4 glypican 4
GPM6A glycoprotein M6A
GRN granulin
GSN gelsolin
HBB hemoglobin, beta
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HMGN5 high mobility group nucleosome binding domain 5
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
IDS iduronate 2-sulfatase
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IFITM3 interferon induced transmembrane protein 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
ISG15 ISG15 ubiquitin-like modifier
ISYNA1 inositol-3-phosphate synthase 1
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
LAMP3 lysosomal-associated membrane protein 3
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial)
LTA4H leukotriene A4 hydrolase
LTBP1 latent transforming growth factor beta binding protein 1
MAN2A1 mannosidase, alpha, class 2A, member 1
MAOA monoamine oxidase A
MMP9 matrix metallopeptidase 9
MYO6 myosin VI
NELL2 NEL-like 2 (chicken)
NMU neuromedin U
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin
PAIP1 poly(A) binding protein interacting protein 1
PCYOX1 prenylcysteine oxidase 1
PFKM phosphofructokinase, muscle
PLS3 plastin 3
PPT1 palmitoyl-protein thioesterase 1
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRSS21 protease, serine, 21 (testisin)
PSPH phosphoserine phosphatase
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RBP1 retinol binding protein 1, cellular
RGCC regulator of cell cycle
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
S100A8 S100 calcium binding protein A8
SCARB2 scavenger receptor class B, member 2
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SELENBP1 selenium binding protein 1
SEPT10 septin 10
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFTPB surfactant protein B
SKP1 S-phase kinase-associated protein 1
SPRED2 sprouty-related, EVH1 domain containing 2
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
TMEM131 transmembrane protein 131
TMEM45A transmembrane protein 45A
TMSB15A thymosin beta 15a
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TPGS2 tubulin polyglutamylase complex subunit 2
TPSAB1 tryptase alpha/beta 1
VNN1 vanin 1
WFDC1 WAP four-disulfide core domain 1

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ACBD3 acyl-CoA binding domain containing 3
ADM adrenomedullin
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AKAP12 A kinase (PRKA) anchor protein 12
AMD1 adenosylmethionine decarboxylase 1
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARID4B AT rich interactive domain 4B (RBP1-like)
ARL4A ADP-ribosylation factor-like 4A
ARMCX6 armadillo repeat containing, X-linked 6
ASNSD1 asparagine synthetase domain containing 1
AURKA aurora kinase A
BAG3 BCL2-associated athanogene 3
BAG5 BCL2-associated athanogene 5
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
BLCAP bladder cancer associated protein
C14ORF169 chromosome 14 open reading frame 169
CBR3 carbonyl reductase 3
CCDC59 coiled-coil domain containing 59
CCNA2 cyclin A2
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CDK7 cyclin-dependent kinase 7
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2AIP CDKN2A interacting protein
CDR2 cerebellar degeneration-related protein 2, 62kDa
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CHERP calcium homeostasis endoplasmic reticulum protein
CHIC2 cysteine-rich hydrophobic domain 2
CKS2 CDC28 protein kinase regulatory subunit 2
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL14 chemokine (C-X-C motif) ligand 14
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DBF4 DBF4 zinc finger
DDIT4 DNA-damage-inducible transcript 4
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP10 dual specificity phosphatase 10
DUSP5 dual specificity phosphatase 5
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
EED embryonic ectoderm development
EGFR epidermal growth factor receptor
EGR2 early growth response 2
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EXOSC4 exosome component 4
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FASTKD5 FAST kinase domains 5
FBL fibrillarin
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
FOXJ3 forkhead box J3
FOXO3 forkhead box O3
FZD7 frizzled class receptor 7
GABPB1 GA binding protein transcription factor, beta subunit 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GADD45B growth arrest and DNA-damage-inducible, beta
GDF15 growth differentiation factor 15
GEM GTP binding protein overexpressed in skeletal muscle
GGNBP2 gametogenetin binding protein 2
GLS glutaminase
GOSR1 golgi SNAP receptor complex member 1
GRWD1 glutamate-rich WD repeat containing 1
GSPT2 G1 to S phase transition 2
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HILPDA hypoxia inducible lipid droplet-associated
HMOX1 heme oxygenase 1
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HOMER1 homer scaffolding protein 1
HOXA10 homeobox A10
HOXA5 homeobox A5
HOXC6 homeobox C6
HSPA14 heat shock 70kDa protein 14
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
IER2 immediate early response 2
IER3 immediate early response 3
IGFBP4 insulin-like growth factor binding protein 4
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
INSIG1 insulin induced gene 1
IRS2 insulin receptor substrate 2
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
KAT6A K(lysine) acetyltransferase 6A
KBTBD2 kelch repeat and BTB (POZ) domain containing 2
KEAP1 kelch-like ECH-associated protein 1
KIN Kin17 DNA and RNA binding protein
KLF10 Kruppel-like factor 10
KLF2 Kruppel-like factor 2
KRT14 keratin 14, type I
KRT6B keratin 6B, type II
KRT7 keratin 7, type II
LOX lysyl oxidase
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPK6 mitogen-activated protein kinase 6
MCM10 minichromosome maintenance complex component 10
MID1 midline 1
MSANTD2 Myb/SANT-like DNA-binding domain containing 2
MTF2 metal response element binding transcription factor 2
MTPAP mitochondrial poly(A) polymerase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NET1 neuroepithelial cell transforming 1
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGDN neuroguidin, EIF4E binding protein
NOP16 NOP16 nucleolar protein
NOP56 NOP56 ribonucleoprotein
NOTCH2NL notch 2 N-terminal like
NR2F6 nuclear receptor subfamily 2, group F, member 6
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
NXT1 nuclear transport factor 2-like export factor 1
OXTR oxytocin receptor
PANK2 pantothenate kinase 2
PARP2 poly (ADP-ribose) polymerase 2
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PDGFA platelet-derived growth factor alpha polypeptide
PDLIM5 PDZ and LIM domain 5
PFKP phosphofructokinase, platelet
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLIN2 perilipin 2
PLK1 polo-like kinase 1
PLK2 polo-like kinase 2
PPIF peptidylprolyl isomerase F
PTX3 pentraxin 3, long
RBM15 RNA binding motif protein 15
RBM7 RNA binding motif protein 7
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
RIN2 Ras and Rab interactor 2
RNF139 ring finger protein 139
RPL36AL ribosomal protein L36a-like
RPP38 ribonuclease P/MRP 38kDa subunit
RRP1B ribosomal RNA processing 1B
SACS sacsin molecular chaperone
SAP30 Sin3A-associated protein, 30kDa
SASH1 SAM and SH3 domain containing 1
SAV1 salvador family WW domain containing protein 1
SCAF8 SR-related CTD-associated factor 8
SERTAD2 SERTA domain containing 2
SETD5 SET domain containing 5
SFRP1 secreted frizzled-related protein 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SMAD3 SMAD family member 3
SMAD7 SMAD family member 7
SNRPE small nuclear ribonucleoprotein polypeptide E
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPHK1 sphingosine kinase 1
SPRY2 sprouty homolog 2 (Drosophila)
STC2 stanniocalcin 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNJ2 synaptojanin 2
TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
TBC1D4 TBC1 domain family, member 4
TBP TATA box binding protein
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TCTA T-cell leukemia translocation altered
TEX10 testis expressed 10
TEX30 testis expressed 30
TFF1 trefoil factor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGIF1 TGFB-induced factor homeobox 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TIPIN TIMELESS interacting protein
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM4SF1 transmembrane 4 L six family member 1
TMEM11 transmembrane protein 11
TMEM243 transmembrane protein 243, mitochondrial
TNPO1 transportin 1
TRAM2 translocation associated membrane protein 2
TSC22D2 TSC22 domain family, member 2
TXLNA taxilin alpha
UCK2 uridine-cytidine kinase 2
UGCG UDP-glucose ceramide glucosyltransferase
USP1 ubiquitin specific peptidase 1
VEZF1 vascular endothelial zinc finger 1
WDR6 WD repeat domain 6
WDR82 WD repeat domain 82
WEE1 WEE1 G2 checkpoint kinase
WIPF2 WAS/WASL interacting protein family, member 2
WSB1 WD repeat and SOCS box containing 1
XBP1 X-box binding protein 1
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
YTHDF2 YTH N(6)-methyladenosine RNA binding protein 2
ZBTB1 zinc finger and BTB domain containing 1
ZBTB18 zinc finger and BTB domain containing 18
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF22 zinc finger protein 22
ZNF410 zinc finger protein 410