BRD-A51777634_-666_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

269 genes differentially expressed following the BRD-A51777634_-666_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACKR3 atypical chemokine receptor 3
ADM adrenomedullin
AKAP12 A kinase (PRKA) anchor protein 12
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANXA1 annexin A1
APOLD1 apolipoprotein L domain containing 1
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BAMBI BMP and activin membrane-bound inhibitor
BIRC3 baculoviral IAP repeat containing 3
BMP2 bone morphogenetic protein 2
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BPGM 2,3-bisphosphoglycerate mutase
BTG1 B-cell translocation gene 1, anti-proliferative
BTG3 BTG family, member 3
C10ORF10 chromosome 10 open reading frame 10
C1ORF106 chromosome 1 open reading frame 106
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CBS cystathionine-beta-synthase
CCNG2 cyclin G2
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CHIC2 cysteine-rich hydrophobic domain 2
CLIC5 chloride intracellular channel 5
CSRP1 cysteine and glycine-rich protein 1
CTH cystathionine gamma-lyase
CYTIP cytohesin 1 interacting protein
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHRS9 dehydrogenase/reductase (SDR family) member 9
DKK3 dickkopf WNT signaling pathway inhibitor 3
DMD dystrophin
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
EFNA1 ephrin-A1
EGFR epidermal growth factor receptor
EGLN3 egl-9 family hypoxia-inducible factor 3
ENO2 enolase 2 (gamma, neuronal)
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
EPAS1 endothelial PAS domain protein 1
ERO1L ERO1-like (S. cerevisiae)
FAM129A family with sequence similarity 129, member A
FBN2 fibrillin 2
FCGBP Fc fragment of IgG binding protein
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FN1 fibronectin 1
FOXO3 forkhead box O3
FRZB frizzled-related protein
FUCA1 fucosidase, alpha-L- 1, tissue
FXYD6 FXYD domain containing ion transport regulator 6
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
GLIPR1 GLI pathogenesis-related 1
GLRX glutaredoxin (thioltransferase)
GLS glutaminase
GPR137B G protein-coupled receptor 137B
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRAMD3 GRAM domain containing 3
GSN gelsolin
GTPBP2 GTP binding protein 2
HBEGF heparin-binding EGF-like growth factor
HBP1 HMG-box transcription factor 1
HECA headcase homolog (Drosophila)
HEPH hephaestin
HILPDA hypoxia inducible lipid droplet-associated
HK2 hexokinase 2
HMOX1 heme oxygenase 1
HSPA2 heat shock 70kDa protein 2
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IL1A interleukin 1, alpha
INHBA inhibin, beta A
INSIG2 insulin induced gene 2
ISG15 ISG15 ubiquitin-like modifier
ISG20 interferon stimulated exonuclease gene 20kDa
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGB4 integrin, beta 4
ITM2C integral membrane protein 2C
JMJD6 jumonji domain containing 6
JOSD1 Josephin domain containing 1
KCNK1 potassium channel, two pore domain subfamily K, member 1
KDM3A lysine (K)-specific demethylase 3A
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
KRT17 keratin 17, type I
KRT20 keratin 20, type I
KRT6B keratin 6B, type II
LAMA3 laminin, alpha 3
LAMB3 laminin, beta 3
LAMC2 laminin, gamma 2
LAMP2 lysosomal-associated membrane protein 2
LGALS4 lectin, galactoside-binding, soluble, 4
LITAF lipopolysaccharide-induced TNF factor
LSR lipolysis stimulated lipoprotein receptor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MFAP5 microfibrillar associated protein 5
MGST3 microsomal glutathione S-transferase 3
MMP12 matrix metallopeptidase 12
MT1F metallothionein 1F
MT1M metallothionein 1M
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MUC13 mucin 13, cell surface associated
MXI1 MAX interactor 1, dimerization protein
NCAM1 neural cell adhesion molecule 1
NDRG1 N-myc downstream regulated 1
NFIL3 nuclear factor, interleukin 3 regulated
NLRP2 NLR family, pyrin domain containing 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRCAM neuronal cell adhesion molecule
NT5C2 5'-nucleotidase, cytosolic II
NUPR1 nuclear protein, transcriptional regulator, 1
P3H2 prolyl 3-hydroxylase 2
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHGDH phosphoglycerate dehydrogenase
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPARD peroxisome proliferator-activated receptor delta
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PROM1 prominin 1
PRSS8 protease, serine, 8
PSAT1 phosphoserine aminotransferase 1
PTHLH parathyroid hormone-like hormone
PXDC1 PX domain containing 1
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAB9A RAB9A, member RAS oncogene family
RABGAP1L RAB GTPase activating protein 1-like
RBP1 retinol binding protein 1, cellular
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
REG1A regenerating islet-derived 1 alpha
RHOC ras homolog family member C
RIOK3 RIO kinase 3
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SAT1 spermidine/spermine N1-acetyltransferase 1
SDC2 syndecan 2
SERINC3 serine incorporator 3
SERINC5 serine incorporator 5
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX4 SRY (sex determining region Y)-box 4
SPINT1 serine peptidase inhibitor, Kunitz type 1
SQSTM1 sequestosome 1
STC1 stanniocalcin 1
STC2 stanniocalcin 2
STK17A serine/threonine kinase 17a
TARS threonyl-tRNA synthetase
TGFA transforming growth factor, alpha
TIMP3 TIMP metallopeptidase inhibitor 3
TMBIM1 transmembrane BAX inhibitor motif containing 1
TMEM2 transmembrane protein 2
TNIP1 TNFAIP3 interacting protein 1
TSC22D3 TSC22 domain family, member 3
TSPAN7 tetraspanin 7
TUFT1 tuftelin 1
UBE2H ubiquitin-conjugating enzyme E2H
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
VGLL4 vestigial-like family member 4
VLDLR very low density lipoprotein receptor
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ACP6 acid phosphatase 6, lysophosphatidic
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ASRGL1 asparaginase like 1
BANF1 barrier to autointegration factor 1
BCLAF1 BCL2-associated transcription factor 1
BIRC5 baculoviral IAP repeat containing 5
CCNA2 cyclin A2
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CEP55 centrosomal protein 55kDa
CLDN10 claudin 10
CLEC11A C-type lectin domain family 11, member A
CXCL9 chemokine (C-X-C motif) ligand 9
DBF4 DBF4 zinc finger
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DPYD dihydropyrimidine dehydrogenase
ECI2 enoyl-CoA delta isomerase 2
EIF4B eukaryotic translation initiation factor 4B
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
ETFB electron-transfer-flavoprotein, beta polypeptide
FASN fatty acid synthase
GNL3 guanine nucleotide binding protein-like 3 (nucleolar)
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial
HIST1H4C histone cluster 1, H4c
HMGB3 high mobility group box 3
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPE1 heat shock 10kDa protein 1
IFRD2 interferon-related developmental regulator 2
IGFBP4 insulin-like growth factor binding protein 4
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
IRX5 iroquois homeobox 5
ISOC2 isochorismatase domain containing 2
KCTD12 potassium channel tetramerization domain containing 12
KIF20A kinesin family member 20A
LOXL1 lysyl oxidase-like 1
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
LUM lumican
MRPL3 mitochondrial ribosomal protein L3
NDUFAF3 NADH dehydrogenase (ubiquinone) complex I, assembly factor 3
NHP2 NHP2 ribonucleoprotein
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NOP16 NOP16 nucleolar protein
NPM3 nucleophosmin/nucleoplasmin 3
ODC1 ornithine decarboxylase 1
PA2G4 proliferation-associated 2G4, 38kDa
PBK PDZ binding kinase
PFKM phosphofructokinase, muscle
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PNKP polynucleotide kinase 3'-phosphatase
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)
PRMT1 protein arginine methyltransferase 1
PRPF31 pre-mRNA processing factor 31
PRR7 proline rich 7 (synaptic)
RGS2 regulator of G-protein signaling 2
RPP40 ribonuclease P/MRP 40kDa subunit
RRP1B ribosomal RNA processing 1B
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RUVBL1 RuvB-like AAA ATPase 1
SERBP1 SERPINE1 mRNA binding protein 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SPDEF SAM pointed domain containing ETS transcription factor
SRM spermidine synthase
SRSF1 serine/arginine-rich splicing factor 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
STEAP3 STEAP family member 3, metalloreductase
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TARP TCR gamma alternate reading frame protein
TMEM97 transmembrane protein 97
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSTA3 tissue specific transplantation antigen P35B
UBE2S ubiquitin-conjugating enzyme E2S
VARS valyl-tRNA synthetase
WDR12 WD repeat domain 12
WDR3 WD repeat domain 3
ZBTB18 zinc finger and BTB domain containing 18