BRD-A51777634_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

300 genes differentially expressed following the BRD-A51777634_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADM adrenomedullin
AK4 adenylate kinase 4
ALDOA aldolase A, fructose-bisphosphate
ALDOC aldolase C, fructose-bisphosphate
AP3S1 adaptor-related protein complex 3, sigma 1 subunit
AREG amphiregulin
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPH aspartate beta-hydroxylase
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BHLHE40 basic helix-loop-helix family, member e40
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CA9 carbonic anhydrase IX
CCL20 chemokine (C-C motif) ligand 20
CD99 CD99 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CERS6 ceramide synthase 6
COL11A1 collagen, type XI, alpha 1
COMP cartilage oligomeric matrix protein
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
CXCL8 chemokine (C-X-C motif) ligand 8
DARS aspartyl-tRNA synthetase
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT4 DNA-damage-inducible transcript 4
DSP desmoplakin
DUSP4 dual specificity phosphatase 4
EFNA1 ephrin-A1
EGLN3 egl-9 family hypoxia-inducible factor 3
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ENO2 enolase 2 (gamma, neuronal)
ERBB2 erb-b2 receptor tyrosine kinase 2
ERO1L ERO1-like (S. cerevisiae)
FAM13A family with sequence similarity 13, member A
FAM162A family with sequence similarity 162, member A
FAM46A family with sequence similarity 46, member A
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FN1 fibronectin 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GBE1 glucan (1,4-alpha-), branching enzyme 1
GDF15 growth differentiation factor 15
GM2A GM2 ganglioside activator
GOLGA8A golgin A8 family, member A
GPI glucose-6-phosphate isomerase
GPNMB glycoprotein (transmembrane) nmb
GSN gelsolin
GTPBP2 GTP binding protein 2
HECA headcase homolog (Drosophila)
HEPH hephaestin
HILPDA hypoxia inducible lipid droplet-associated
HK2 hexokinase 2
HLA-B major histocompatibility complex, class I, B
HMOX1 heme oxygenase 1
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HOMER1 homer scaffolding protein 1
IFI27 interferon, alpha-inducible protein 27
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
INHBA inhibin, beta A
INHBB inhibin, beta B
INSIG2 insulin induced gene 2
INSR insulin receptor
KDM3A lysine (K)-specific demethylase 3A
KDM6A lysine (K)-specific demethylase 6A
KLF6 Kruppel-like factor 6
KRT20 keratin 20, type I
KRT23 keratin 23, type I
LCN2 lipocalin 2
LOC100272216 uncharacterized LOC100272216
LOX lysyl oxidase
LOXL2 lysyl oxidase-like 2
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MFAP5 microfibrillar associated protein 5
MFSD10 major facilitator superfamily domain containing 10
MKNK2 MAP kinase interacting serine/threonine kinase 2
MMP12 matrix metallopeptidase 12
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MXI1 MAX interactor 1, dimerization protein
NDRG1 N-myc downstream regulated 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFIL3 nuclear factor, interleukin 3 regulated
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRN1 neuritin 1
NUPR1 nuclear protein, transcriptional regulator, 1
OPN3 opsin 3
OPTN optineurin
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PAM peptidylglycine alpha-amidating monooxygenase
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PERP PERP, TP53 apoptosis effector
PFKP phosphofructokinase, platelet
PGK1 phosphoglycerate kinase 1
PGM1 phosphoglucomutase 1
PHGDH phosphoglycerate dehydrogenase
PHLDA3 pleckstrin homology-like domain, family A, member 3
PKM pyruvate kinase, muscle
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PMEPA1 prostate transmembrane protein, androgen induced 1
POPDC3 popeye domain containing 3
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4
PRTN3 proteinase 3
PSAT1 phosphoserine aminotransferase 1
PXDN peroxidasin
RIOK3 RIO kinase 3
RLF rearranged L-myc fusion
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNASET2 ribonuclease T2
RNMT RNA (guanine-7-) methyltransferase
RPS27L ribosomal protein S27-like
S100A4 S100 calcium binding protein A4
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCARB1 scavenger receptor class B, member 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SESN1 sestrin 1
SH3BGR SH3 domain binding glutamate-rich protein
SIK1 salt-inducible kinase 1
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX9 SRY (sex determining region Y)-box 9
SPAG4 sperm associated antigen 4
SST somatostatin
STC1 stanniocalcin 1
SULF1 sulfatase 1
TF transferrin
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TGFA transforming growth factor, alpha
TGFBI transforming growth factor, beta-induced, 68kDa
TIGAR TP53 induced glycolysis regulatory phosphatase
TIMP3 TIMP metallopeptidase inhibitor 3
TMCC1 transmembrane and coiled-coil domain family 1
TMEM45A transmembrane protein 45A
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNIP1 TNFAIP3 interacting protein 1
TPI1 triosephosphate isomerase 1
TSC22D3 TSC22 domain family, member 3
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
TXNRD1 thioredoxin reductase 1
VEGFA vascular endothelial growth factor A
VLDLR very low density lipoprotein receptor
WSB1 WD repeat and SOCS box containing 1
YPEL5 yippee-like 5 (Drosophila)
ZMAT3 zinc finger, matrin-type 3
ZMYM2 zinc finger, MYM-type 2
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ANPEP alanyl (membrane) aminopeptidase
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ASRGL1 asparaginase like 1
AURKA aurora kinase A
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C20ORF27 chromosome 20 open reading frame 27
C7 complement component 7
CCDC109B coiled-coil domain containing 109B
CCL19 chemokine (C-C motif) ligand 19
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNF cyclin F
CD14 CD14 molecule
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDCA3 cell division cycle associated 3
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CKS2 CDC28 protein kinase regulatory subunit 2
CLU clusterin
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL12 chemokine (C-X-C motif) ligand 12
DBF4 DBF4 zinc finger
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DEPDC1 DEP domain containing 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DPH2 DPH2 homolog (S. cerevisiae)
DPYD dihydropyrimidine dehydrogenase
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ELOVL6 ELOVL fatty acid elongase 6
EML3 echinoderm microtubule associated protein like 3
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
ESR1 estrogen receptor 1
F12 coagulation factor XII (Hageman factor)
FAM64A family with sequence similarity 64, member A
FBP1 fructose-1,6-bisphosphatase 1
FEN1 flap structure-specific endonuclease 1
FJX1 four jointed box 1 (Drosophila)
FOXM1 forkhead box M1
FXYD2 FXYD domain containing ion transport regulator 2
GATA3 GATA binding protein 3
GINS2 GINS complex subunit 2 (Psf2 homolog)
GTSE1 G-2 and S-phase expressed 1
H2BFS H2B histone family, member S (pseudogene)
HIST1H2BK histone cluster 1, H2bk
HIST1H4C histone cluster 1, H4c
HIST3H2A histone cluster 3, H2a
HJURP Holliday junction recognition protein
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
IGFBP4 insulin-like growth factor binding protein 4
IGHM immunoglobulin heavy constant mu
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
JCHAIN joining chain of multimeric IgA and IgM
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF18A kinesin family member 18A
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF22 kinesin family member 22
KIF23 kinesin family member 23
KIF2C kinesin family member 2C
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LMNB1 lamin B1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MECOM MDS1 and EVI1 complex locus
MKI67 marker of proliferation Ki-67
MRPL12 mitochondrial ribosomal protein L12
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NAV2 neuron navigator 2
NCAPH non-SMC condensin I complex, subunit H
NEK2 NIMA-related kinase 2
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NFIB nuclear factor I/B
NHP2 NHP2 ribonucleoprotein
NOP56 NOP56 ribonucleoprotein
NPY1R neuropeptide Y receptor Y1
ODC1 ornithine decarboxylase 1
OIP5 Opa interacting protein 5
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PBK PDZ binding kinase
PLK1 polo-like kinase 1
PODXL podocalyxin-like
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRC1 protein regulator of cytokinesis 1
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
PTTG1 pituitary tumor-transforming 1
RACGAP1 Rac GTPase activating protein 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RBBP8 retinoblastoma binding protein 8
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RGS5 regulator of G-protein signaling 5
RNASEH2A ribonuclease H2, subunit A
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SFRP1 secreted frizzled-related protein 1
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SMC2 structural maintenance of chromosomes 2
SMC4 structural maintenance of chromosomes 4
SPC25 SPC25, NDC80 kinetochore complex component
SPON1 spondin 1, extracellular matrix protein
SRSF6 serine/arginine-rich splicing factor 6
STMN1 stathmin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TFPI2 tissue factor pathway inhibitor 2
TIMELESS timeless circadian clock
TMPO thymopoietin
TNC tenascin C
TOP2A topoisomerase (DNA) II alpha 170kDa
TPBG trophoblast glycoprotein
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TRMT5 tRNA methyltransferase 5
TROAP trophinin associated protein
TSPAN4 tetraspanin 4
TTK TTK protein kinase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UGCG UDP-glucose ceramide glucosyltransferase
VCAN versican
ZWINT ZW10 interacting kinetochore protein