BRD-A50928468_NORGESTREL_VCAP_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

310 genes differentially expressed following the BRD-A50928468_NORGESTREL_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACOT9 acyl-CoA thioesterase 9
ACSL3 acyl-CoA synthetase long-chain family member 3
ADM adrenomedullin
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANPEP alanyl (membrane) aminopeptidase
ARMCX3 armadillo repeat containing, X-linked 3
ASRGL1 asparaginase like 1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BASP1 brain abundant, membrane attached signal protein 1
C14ORF132 chromosome 14 open reading frame 132
C6ORF62 chromosome 6 open reading frame 62
CADM1 cell adhesion molecule 1
CARD10 caspase recruitment domain family, member 10
CD163 CD163 molecule
CD47 CD47 molecule
CD9 CD9 molecule
CD99 CD99 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CFB complement factor B
CKAP4 cytoskeleton-associated protein 4
CLIC5 chloride intracellular channel 5
COL4A5 collagen, type IV, alpha 5
CREB3L1 cAMP responsive element binding protein 3-like 1
CYB5R1 cytochrome b5 reductase 1
CYB5R2 cytochrome b5 reductase 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10
EDN3 endothelin 3
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
F3 coagulation factor III (thromboplastin, tissue factor)
FAM189A2 family with sequence similarity 189, member A2
FBN2 fibrillin 2
FHL1 four and a half LIM domains 1
FKBP1B FK506 binding protein 1B, 12.6 kDa
GAB2 GRB2-associated binding protein 2
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLRX glutaredoxin (thioltransferase)
GLUL glutamate-ammonia ligase
GNMT glycine N-methyltransferase
GPER1 G protein-coupled estrogen receptor 1
GREB1 growth regulation by estrogen in breast cancer 1
HOMER2 homer scaffolding protein 2
HSPA2 heat shock 70kDa protein 2
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IFITM1 interferon induced transmembrane protein 1
IL1R1 interleukin 1 receptor, type I
INPP1 inositol polyphosphate-1-phosphatase
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
ISG20 interferon stimulated exonuclease gene 20kDa
KIAA1324 KIAA1324
KLK2 kallikrein-related peptidase 2
LEPROT leptin receptor overlapping transcript
LGMN legumain
LIMK2 LIM domain kinase 2
LINC00341 long intergenic non-protein coding RNA 341
MATN2 matrilin 2
MEIS2 Meis homeobox 2
MFAP5 microfibrillar associated protein 5
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MME membrane metallo-endopeptidase
MSMB microseminoprotein, beta-
MSX2 msh homeobox 2
MT1M metallothionein 1M
MXRA7 matrix-remodelling associated 7
NUCB2 nucleobindin 2
NUPR1 nuclear protein, transcriptional regulator, 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OLFML2A olfactomedin-like 2A
ORMDL2 ORMDL sphingolipid biosynthesis regulator 2
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PCDH7 protocadherin 7
PDZD2 PDZ domain containing 2
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLSCR3 phospholipid scramblase 3
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
RAB6A RAB6A, member RAS oncogene family
RAB9A RAB9A, member RAS oncogene family
RAP1GAP RAP1 GTPase activating protein
RGCC regulator of cell cycle
RHOBTB3 Rho-related BTB domain containing 3
RUNX1 runt-related transcription factor 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SEC14L2 SEC14-like 2 (S. cerevisiae)
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)
SERINC5 serine incorporator 5
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SHANK2 SH3 and multiple ankyrin repeat domains 2
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC35E3 solute carrier family 35, member E3
SOCS2 suppressor of cytokine signaling 2
SOX17 SRY (sex determining region Y)-box 17
SPDEF SAM pointed domain containing ETS transcription factor
SST somatostatin
TCF4 transcription factor 4
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TJP1 tight junction protein 1
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNS3 tensin 3
TP53I3 tumor protein p53 inducible protein 3
TPP1 tripeptidyl peptidase I
WBP5 WW domain binding protein 5
WIPI1 WD repeat domain, phosphoinositide interacting 1
WSB2 WD repeat and SOCS box containing 2
XBP1 X-box binding protein 1
YPEL5 yippee-like 5 (Drosophila)
ZFP36 ZFP36 ring finger protein
ZIC1 Zic family member 1

decreased expression

Symbol Name
ADGRE5 adhesion G protein-coupled receptor E5
AKAP7 A kinase (PRKA) anchor protein 7
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
BARD1 BRCA1 associated RING domain 1
BCHE butyrylcholinesterase
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BIRC5 baculoviral IAP repeat containing 5
BOP1 block of proliferation 1
BRCA1 breast cancer 1, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
BUB3 BUB3 mitotic checkpoint protein
C1QBP complement component 1, q subcomponent binding protein
CA12 carbonic anhydrase XII
CACYBP calcyclin binding protein
CCDC85B coiled-coil domain containing 85B
CCL19 chemokine (C-C motif) ligand 19
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNF cyclin F
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDC7 cell division cycle 7
CDCA4 cell division cycle associated 4
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CDT1 chromatin licensing and DNA replication factor 1
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CENPU centromere protein U
CHEK2 checkpoint kinase 2
CKAP2 cytoskeleton associated protein 2
CKS2 CDC28 protein kinase regulatory subunit 2
CLU clusterin
CSE1L CSE1 chromosome segregation 1-like (yeast)
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL9 chemokine (C-X-C motif) ligand 9
CYCS cytochrome c, somatic
CYFIP2 cytoplasmic FMR1 interacting protein 2
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DHFR dihydrofolate reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EIF4A3 eukaryotic translation initiation factor 4A3
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
EXO1 exonuclease 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
F12 coagulation factor XII (Hageman factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FANCG Fanconi anemia, complementation group G
FANCI Fanconi anemia, complementation group I
FAS Fas cell surface death receptor
FBL fibrillarin
GAS1 growth arrest-specific 1
GINS2 GINS complex subunit 2 (Psf2 homolog)
GNG12 guanine nucleotide binding protein (G protein), gamma 12
GPI glucose-6-phosphate isomerase
GTSE1 G-2 and S-phase expressed 1
GUSBP11 glucuronidase, beta pseudogene 11
HEATR1 HEAT repeat containing 1
HELLS helicase, lymphoid-specific
HES1 hes family bHLH transcription factor 1
HJURP Holliday junction recognition protein
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HN1 hematological and neurological expressed 1
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
HOPX HOP homeobox
HOXC6 homeobox C6
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IGFBP3 insulin-like growth factor binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
IL33 interleukin 33
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
ITGB3BP integrin beta 3 binding protein (beta3-endonexin)
KIAA0922 KIAA0922
KIF15 kinesin family member 15
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
LAMP5 lysosomal-associated membrane protein family, member 5
LDHB lactate dehydrogenase B
LGALS4 lectin, galactoside-binding, soluble, 4
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LMO3 LIM domain only 3 (rhombotin-like 2)
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAK16 MAK16 homolog (S. cerevisiae)
MARCKS myristoylated alanine-rich protein kinase C substrate
MCM2 minichromosome maintenance complex component 2
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MELK maternal embryonic leucine zipper kinase
MET MET proto-oncogene, receptor tyrosine kinase
MKI67 marker of proliferation Ki-67
MRPL12 mitochondrial ribosomal protein L12
MRPS2 mitochondrial ribosomal protein S2
MRPS30 mitochondrial ribosomal protein S30
MTA1 metastasis associated 1
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCAPG2 non-SMC condensin II complex, subunit G2
NCAPH non-SMC condensin I complex, subunit H
NDC1 NDC1 transmembrane nucleoporin
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NHP2 NHP2 ribonucleoprotein
NIT2 nitrilase family, member 2
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOLC1 nucleolar and coiled-body phosphoprotein 1
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NPY1R neuropeptide Y receptor Y1
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor
NUP210 nucleoporin 210kDa
NUSAP1 nucleolar and spindle associated protein 1
OXCT1 3-oxoacid CoA transferase 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PCYOX1L prenylcysteine oxidase 1 like
PHGDH phosphoglycerate dehydrogenase
PLK1 polo-like kinase 1
PNP purine nucleoside phosphorylase
POLR1E polymerase (RNA) I polypeptide E, 53kDa
POU2AF1 POU class 2 associating factor 1
PPAT phosphoribosyl pyrophosphate amidotransferase
PPIH peptidylprolyl isomerase H (cyclophilin H)
PRC1 protein regulator of cytokinesis 1
PRDX2 peroxiredoxin 2
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRPS2 phosphoribosyl pyrophosphate synthetase 2
PRR7 proline rich 7 (synaptic)
PSAT1 phosphoserine aminotransferase 1
PSIP1 PC4 and SFRS1 interacting protein 1
PTTG1 pituitary tumor-transforming 1
RANBP1 RAN binding protein 1
RFC3 replication factor C (activator 1) 3, 38kDa
RGS2 regulator of G-protein signaling 2
RNASEH2A ribonuclease H2, subunit A
RPA3 replication protein A3, 14kDa
RRM2 ribonucleotide reductase M2
RRP1B ribosomal RNA processing 1B
RUFY3 RUN and FYVE domain containing 3
RUVBL2 RuvB-like AAA ATPase 2
SEH1L SEH1-like (S. cerevisiae)
SEPT11 septin 11
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SF3A3 splicing factor 3a, subunit 3, 60kDa
SIGMAR1 sigma non-opioid intracellular receptor 1
SLIRP SRA stem-loop interacting RNA binding protein
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRSF7 serine/arginine-rich splicing factor 7
ST7 suppression of tumorigenicity 7
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TARBP1 TAR (HIV-1) RNA binding protein 1
TFAM transcription factor A, mitochondrial
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMEM109 transmembrane protein 109
TMEM45A transmembrane protein 45A
TMEM97 transmembrane protein 97
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53 tumor protein p53
TPX2 TPX2, microtubule-associated
TRIB1 tribbles pseudokinase 1
TRIP13 thyroid hormone receptor interactor 13
TSPAN8 tetraspanin 8
TTK TTK protein kinase
TUBB tubulin, beta class I
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
URI1 URI1, prefoldin-like chaperone
VCAM1 vascular cell adhesion molecule 1