BRD-A50774520_-666_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

160 genes differentially expressed following the BRD-A50774520_-666_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
AZIN1 antizyme inhibitor 1
BAG3 BCL2-associated athanogene 3
C6ORF62 chromosome 6 open reading frame 62
CA2 carbonic anhydrase II
CD52 CD52 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CEMIP cell migration inducing protein, hyaluronan binding
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COL6A2 collagen, type VI, alpha 2
COL9A2 collagen, type IX, alpha 2
COL9A3 collagen, type IX, alpha 3
CRABP2 cellular retinoic acid binding protein 2
CSF3R colony stimulating factor 3 receptor (granulocyte)
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DUSP6 dual specificity phosphatase 6
EIF5 eukaryotic translation initiation factor 5
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
EVI2A ecotropic viral integration site 2A
EVI2B ecotropic viral integration site 2B
FAM69A family with sequence similarity 69, member A
FN1 fibronectin 1
FOXD1 forkhead box D1
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GMFG glia maturation factor, gamma
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMOX1 heme oxygenase 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IFRD1 interferon-related developmental regulator 1
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL7R interleukin 7 receptor
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KIF14 kinesin family member 14
KLK6 kallikrein-related peptidase 6
MFSD10 major facilitator superfamily domain containing 10
MICALL1 MICAL-like 1
MMP1 matrix metallopeptidase 1
MTA1 metastasis associated 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYO10 myosin X
MYO1B myosin IB
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDGFA platelet-derived growth factor alpha polypeptide
PHLDA1 pleckstrin homology-like domain, family A, member 1
PKD1P1 polycystic kidney disease 1 (autosomal dominant) pseudogene 1
PPARD peroxisome proliferator-activated receptor delta
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRNP prion protein
PRR7 proline rich 7 (synaptic)
PTX3 pentraxin 3, long
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RYBP RING1 and YY1 binding protein
SARS seryl-tRNA synthetase
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SPP1 secreted phosphoprotein 1
TPD52 tumor protein D52
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TXNRD1 thioredoxin reductase 1
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
WNT5B wingless-type MMTV integration site family, member 5B
XBP1 X-box binding protein 1
XPOT exportin, tRNA

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
ARID5B AT rich interactive domain 5B (MRF1-like)
AURKA aurora kinase A
C3 complement component 3
C8ORF4 chromosome 8 open reading frame 4
CBR1 carbonyl reductase 1
CBR3 carbonyl reductase 3
CCL2 chemokine (C-C motif) ligand 2
CD24 CD24 molecule
CFLAR CASP8 and FADD-like apoptosis regulator
CNN1 calponin 1, basic, smooth muscle
COL14A1 collagen, type XIV, alpha 1
COL4A5 collagen, type IV, alpha 5
CXADR coxsackie virus and adenovirus receptor
CYCS cytochrome c, somatic
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
EBP emopamil binding protein (sterol isomerase)
EGF epidermal growth factor
EPHA3 EPH receptor A3
ESR1 estrogen receptor 1
FBLN1 fibulin 1
FKBP14 FK506 binding protein 14, 22 kDa
FUCA1 fucosidase, alpha-L- 1, tissue
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GSTM3 glutathione S-transferase mu 3 (brain)
HOPX HOP homeobox
HOXA5 homeobox A5
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ICAM1 intercellular adhesion molecule 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP5 insulin-like growth factor binding protein 5
IQGAP2 IQ motif containing GTPase activating protein 2
ISG15 ISG15 ubiquitin-like modifier
KRT13 keratin 13, type I
KRT7 keratin 7, type II
LMO2 LIM domain only 2 (rhombotin-like 1)
MATN2 matrilin 2
MEIS1 Meis homeobox 1
MEIS2 Meis homeobox 2
MTMR1 myotubularin related protein 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPR3 natriuretic peptide receptor 3
NT5DC2 5'-nucleotidase domain containing 2
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PALLD palladin, cytoskeletal associated protein
PBX1 pre-B-cell leukemia homeobox 1
PDLIM3 PDZ and LIM domain 3
PEBP1 phosphatidylethanolamine binding protein 1
PGM1 phosphoglucomutase 1
PODXL podocalyxin-like
PRKCH protein kinase C, eta
PTGDS prostaglandin D2 synthase 21kDa (brain)
RRAGD Ras-related GTP binding D
SDC2 syndecan 2
SFRP1 secreted frizzled-related protein 1
SFRP4 secreted frizzled-related protein 4
SIK1 salt-inducible kinase 1
SOD2 superoxide dismutase 2, mitochondrial
SORD sorbitol dehydrogenase
SOX4 SRY (sex determining region Y)-box 4
STOM stomatin
TACSTD2 tumor-associated calcium signal transducer 2
TCF4 transcription factor 4
TGM2 transglutaminase 2
TTC3 tetratricopeptide repeat domain 3
UPK1B uroplakin 1B
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZBTB20 zinc finger and BTB domain containing 20
ZNF185 zinc finger protein 185 (LIM domain)