BRD-A50737080_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

172 genes differentially expressed following the BRD-A50737080_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
AKAP8 A kinase (PRKA) anchor protein 8
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BCL3 B-cell CLL/lymphoma 3
BGN biglycan
BHLHE40 basic helix-loop-helix family, member e40
BIRC2 baculoviral IAP repeat containing 2
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCL20 chemokine (C-C motif) ligand 20
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CDK17 cyclin-dependent kinase 17
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CHMP1B charged multivesicular body protein 1B
CTGF connective tissue growth factor
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DTNA dystrobrevin, alpha
DUSP1 dual specificity phosphatase 1
EGR1 early growth response 1
EGR3 early growth response 3
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
EPS8 epidermal growth factor receptor pathway substrate 8
EREG epiregulin
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FOLR1 folate receptor 1 (adult)
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
FOXJ3 forkhead box J3
FOXN3 forkhead box N3
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GADD45B growth arrest and DNA-damage-inducible, beta
GARS glycyl-tRNA synthetase
H1F0 H1 histone family, member 0
HBP1 HMG-box transcription factor 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HMOX1 heme oxygenase 1
IER3 immediate early response 3
IFRD1 interferon-related developmental regulator 1
INHBA inhibin, beta A
INHBE inhibin, beta E
JMJD1C jumonji domain containing 1C
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KIAA0226L KIAA0226-like
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KRT14 keratin 14, type I
KRT7 keratin 7, type II
LGALS3 lectin, galactoside-binding, soluble, 3
LMO4 LIM domain only 4
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1B microtubule-associated protein 1B
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MCL1 myeloid cell leukemia 1
MGLL monoglyceride lipase
MMP7 matrix metallopeptidase 7
MT1F metallothionein 1F
MT1M metallothionein 1M
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYO10 myosin X
NAMPT nicotinamide phosphoribosyltransferase
NFE2L2 nuclear factor, erythroid 2-like 2
NFIL3 nuclear factor, interleukin 3 regulated
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
PEG3 paternally expressed 3
PLA2G16 phospholipase A2, group XVI
PLBD1 phospholipase B domain containing 1
PTX3 pentraxin 3, long
QKI QKI, KH domain containing, RNA binding
RB1CC1 RB1-inducible coiled-coil 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGCC regulator of cell cycle
RND3 Rho family GTPase 3
S100P S100 calcium binding protein P
SARS seryl-tRNA synthetase
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SIK1 salt-inducible kinase 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
SLC38A2 solute carrier family 38, member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD3 SMAD family member 3
SOX4 SRY (sex determining region Y)-box 4
SQSTM1 sequestosome 1
STC2 stanniocalcin 2
TGFBI transforming growth factor, beta-induced, 68kDa
THBS1 thrombospondin 1
TXNRD1 thioredoxin reductase 1
XBP1 X-box binding protein 1
YARS tyrosyl-tRNA synthetase
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ACAA1 acetyl-CoA acyltransferase 1
ACTG2 actin, gamma 2, smooth muscle, enteric
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ALOX5 arachidonate 5-lipoxygenase
ANXA2 annexin A2
BLCAP bladder cancer associated protein
C1QTNF3 C1q and tumor necrosis factor related protein 3
C6ORF62 chromosome 6 open reading frame 62
CANT1 calcium activated nucleotidase 1
CCNE2 cyclin E2
CCNF cyclin F
CDC25A cell division cycle 25A
CFB complement factor B
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLU clusterin
CPA3 carboxypeptidase A3 (mast cell)
EPB41L3 erythrocyte membrane protein band 4.1-like 3
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
EXOSC4 exosome component 4
FHL1 four and a half LIM domains 1
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GJA1 gap junction protein, alpha 1, 43kDa
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GOLGA8B golgin A8 family, member B
HBB hemoglobin, beta
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
ITGB1BP1 integrin beta 1 binding protein 1
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
LIG1 ligase I, DNA, ATP-dependent
LOC100272216 uncharacterized LOC100272216
MAGEA3 melanoma antigen family A3
MCAM melanoma cell adhesion molecule
METTL3 methyltransferase like 3
MMP12 matrix metallopeptidase 12
MMP9 matrix metallopeptidase 9
NKG7 natural killer cell granule protein 7
NUSAP1 nucleolar and spindle associated protein 1
PDZK1 PDZ domain containing 1
PRPF4B pre-mRNA processing factor 4B
PXMP2 peroxisomal membrane protein 2, 22kDa
REG1A regenerating islet-derived 1 alpha
RRM2 ribonucleotide reductase M2
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SMCO4 single-pass membrane protein with coiled-coil domains 4
SNX1 sorting nexin 1
TARDBP TAR DNA binding protein
TMEM14B transmembrane protein 14B
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRAPPC3 trafficking protein particle complex 3
TUBB tubulin, beta class I
TUSC3 tumor suppressor candidate 3
UBE3C ubiquitin protein ligase E3C
USP34 ubiquitin specific peptidase 34