BRD-A50737080_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

164 genes differentially expressed following the BRD-A50737080_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ACBD3 acyl-CoA binding domain containing 3
ADM adrenomedullin
ALCAM activated leukocyte cell adhesion molecule
AQP1 aquaporin 1 (Colton blood group)
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
BCL6 B-cell CLL/lymphoma 6
BMP6 bone morphogenetic protein 6
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C6ORF48 chromosome 6 open reading frame 48
CBS cystathionine-beta-synthase
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CEMIP cell migration inducing protein, hyaluronan binding
CFB complement factor B
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CLU clusterin
COBL cordon-bleu WH2 repeat protein
CST3 cystatin C
CTH cystathionine gamma-lyase
CXCL8 chemokine (C-X-C motif) ligand 8
DBT dihydrolipoamide branched chain transacylase E2
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
EGR1 early growth response 1
EIF5A eukaryotic translation initiation factor 5A
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPRS glutamyl-prolyl-tRNA synthetase
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
F3 coagulation factor III (thromboplastin, tissue factor)
FAM107A family with sequence similarity 107, member A
FHL2 four and a half LIM domains 2
FOLR1 folate receptor 1 (adult)
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FRY furry homolog (Drosophila)
FYN FYN proto-oncogene, Src family tyrosine kinase
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GARS glycyl-tRNA synthetase
GDF15 growth differentiation factor 15
GFOD1 glucose-fructose oxidoreductase domain containing 1
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLRX glutaredoxin (thioltransferase)
HIST1H2BG histone cluster 1, H2bg
HMOX1 heme oxygenase 1
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
IARS isoleucyl-tRNA synthetase
IL6 interleukin 6
INHBE inhibin, beta E
ITM2A integral membrane protein 2A
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KLF4 Kruppel-like factor 4 (gut)
KRT23 keratin 23, type I
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAP7 microtubule-associated protein 7
MAPT microtubule-associated protein tau
MARS methionyl-tRNA synthetase
MGP matrix Gla protein
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MMP1 matrix metallopeptidase 1
MMP7 matrix metallopeptidase 7
MT1F metallothionein 1F
MT1M metallothionein 1M
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFIL3 nuclear factor, interleukin 3 regulated
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDE4C phosphodiesterase 4C, cAMP-specific
PDGFA platelet-derived growth factor alpha polypeptide
PDZK1IP1 PDZK1 interacting protein 1
PHGDH phosphoglycerate dehydrogenase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PROM1 prominin 1
PSAT1 phosphoserine aminotransferase 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PYCR1 pyrroline-5-carboxylate reductase 1
RHOBTB3 Rho-related BTB domain containing 3
RPL37A ribosomal protein L37a
RPL38 ribosomal protein L38
SAT1 spermidine/spermine N1-acetyltransferase 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC38A1 solute carrier family 38, member 1
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQSTM1 sequestosome 1
STC2 stanniocalcin 2
STXBP2 syntaxin binding protein 2
TFF3 trefoil factor 3 (intestinal)
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TRIB3 tribbles pseudokinase 3
TSC22D1 TSC22 domain family, member 1
TSPAN8 tetraspanin 8
TXNIP thioredoxin interacting protein
TXNL4B thioredoxin-like 4B
TXNRD1 thioredoxin reductase 1
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
WARS tryptophanyl-tRNA synthetase
XBP1 X-box binding protein 1
XPOT exportin, tRNA
ZNF160 zinc finger protein 160
ZNF721 zinc finger protein 721

decreased expression

Symbol Name
B3GNT1
CA12 carbonic anhydrase XII
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAST calpastatin
CCL5 chemokine (C-C motif) ligand 5
CCNF cyclin F
CD24 CD24 molecule
CNN3 calponin 3, acidic
COL4A5 collagen, type IV, alpha 5
COL4A6 collagen, type IV, alpha 6
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
DUSP4 dual specificity phosphatase 4
EXOSC4 exosome component 4
FBLN1 fibulin 1
FHOD3 formin homology 2 domain containing 3
GBP1 guanylate binding protein 1, interferon-inducible
GLO1 glyoxalase I
GPM6B glycoprotein M6B
GRWD1 glutamate-rich WD repeat containing 1
GSPT2 G1 to S phase transition 2
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
LY6E lymphocyte antigen 6 complex, locus E
MARCKS myristoylated alanine-rich protein kinase C substrate
MDK midkine (neurite growth-promoting factor 2)
MLEC malectin
MXRA7 matrix-remodelling associated 7
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NID1 nidogen 1
NME4 NME/NM23 nucleoside diphosphate kinase 4
NRIP1 nuclear receptor interacting protein 1
PDE4B phosphodiesterase 4B, cAMP-specific
PEG10 paternally expressed 10
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRKCA protein kinase C, alpha
RCAN2 regulator of calcineurin 2
RNF144A ring finger protein 144A
SDC1 syndecan 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SYNM synemin, intermediate filament protein
TMEM255A transmembrane protein 255A