BRD-A50675702_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

133 genes differentially expressed following the BRD-A50675702_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ADAM10 ADAM metallopeptidase domain 10
AFP alpha-fetoprotein
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANXA3 annexin A3
APOLD1 apolipoprotein L domain containing 1
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARPP19 cAMP-regulated phosphoprotein, 19kDa
BMP2 bone morphogenetic protein 2
CA12 carbonic anhydrase XII
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCL20 chemokine (C-C motif) ligand 20
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CFI complement factor I
CRABP2 cellular retinoic acid binding protein 2
CXADR coxsackie virus and adenovirus receptor
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DUOX2 dual oxidase 2
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EPHA2 EPH receptor A2
EREG epiregulin
EZR ezrin
F2RL1 coagulation factor II (thrombin) receptor-like 1
FOLR1 folate receptor 1 (adult)
GABPB1 GA binding protein transcription factor, beta subunit 1
GLDC glycine dehydrogenase (decarboxylating)
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRB10 growth factor receptor-bound protein 10
HBB hemoglobin, beta
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HOXB6 homeobox B6
IER3 immediate early response 3
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IL6ST interleukin 6 signal transducer
JMJD1C jumonji domain containing 1C
KAZN kazrin, periplakin interacting protein
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KIAA0355 KIAA0355
LAMP5 lysosomal-associated membrane protein family, member 5
LCN2 lipocalin 2
LEF1 lymphoid enhancer-binding factor 1
LOX lysyl oxidase
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MFSD10 major facilitator superfamily domain containing 10
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MT1F metallothionein 1F
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
PDLIM5 PDZ and LIM domain 5
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAT plasminogen activator, tissue
PLBD1 phospholipase B domain containing 1
PSD3 pleckstrin and Sec7 domain containing 3
RBM47 RNA binding motif protein 47
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
S100A12 S100 calcium binding protein A12
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG5 secretogranin V
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SMAD3 SMAD family member 3
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SOX4 SRY (sex determining region Y)-box 4
SPINK1 serine peptidase inhibitor, Kazal type 1
TCL1A T-cell leukemia/lymphoma 1A
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TEX10 testis expressed 10
TGFBI transforming growth factor, beta-induced, 68kDa
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIAM1 T-cell lymphoma invasion and metastasis 1
TM4SF1 transmembrane 4 L six family member 1
VCAN versican
VNN1 vanin 1
WASF3 WAS protein family, member 3

decreased expression

Symbol Name
ALOX5 arachidonate 5-lipoxygenase
ASS1 argininosuccinate synthase 1
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
CAV1 caveolin 1, caveolae protein, 22kDa
CD8A CD8a molecule
CD99 CD99 molecule
CDKN2A cyclin-dependent kinase inhibitor 2A
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CFD complement factor D (adipsin)
CHI3L2 chitinase 3-like 2
CHRDL1 chordin-like 1
CIAPIN1 cytokine induced apoptosis inhibitor 1
CLU clusterin
CNTNAP2 contactin associated protein-like 2
COL3A1 collagen, type III, alpha 1
COL9A1 collagen, type IX, alpha 1
DLK1 delta-like 1 homolog (Drosophila)
DPYD dihydropyrimidine dehydrogenase
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFHD1 EF-hand domain family, member D1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP7 fatty acid binding protein 7, brain
GATA3 GATA binding protein 3
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GBP2 guanylate binding protein 2, interferon-inducible
GJA1 gap junction protein, alpha 1, 43kDa
GREB1 growth regulation by estrogen in breast cancer 1
ITGB1BP1 integrin beta 1 binding protein 1
ITM2A integral membrane protein 2A
LOC100272216 uncharacterized LOC100272216
LTF lactotransferrin
MLPH melanophilin
NR2F2 nuclear receptor subfamily 2, group F, member 2
OLFM1 olfactomedin 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAB13 RAB13, member RAS oncogene family
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RRM2 ribonucleotide reductase M2
SCGB2A1 secretoglobin, family 2A, member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SOX11 SRY (sex determining region Y)-box 11
SPDEF SAM pointed domain containing ETS transcription factor
TFRC transferrin receptor
TPSAB1 tryptase alpha/beta 1