BRD-A49848186_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

169 genes differentially expressed following the BRD-A49848186_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRG2 adhesion G protein-coupled receptor G2
ADM adrenomedullin
AGO2 argonaute RISC catalytic component 2
ANXA1 annexin A1
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BTG1 B-cell translocation gene 1, anti-proliferative
CEMIP cell migration inducing protein, hyaluronan binding
CFD complement factor D (adipsin)
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CTGF connective tissue growth factor
DCN decorin
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EMP1 epithelial membrane protein 1
EPHA2 EPH receptor A2
EREG epiregulin
FHL2 four and a half LIM domains 2
FN1 fibronectin 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
FXR1 fragile X mental retardation, autosomal homolog 1
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GARS glycyl-tRNA synthetase
GPRC5A G protein-coupled receptor, class C, group 5, member A
HBEGF heparin-binding EGF-like growth factor
HCAR3 hydroxycarboxylic acid receptor 3
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IL1R2 interleukin 1 receptor, type II
INSIG1 insulin induced gene 1
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KDM5A lysine (K)-specific demethylase 5A
KDM7A lysine (K)-specific demethylase 7A
KLF4 Kruppel-like factor 4 (gut)
KLF5 Kruppel-like factor 5 (intestinal)
KLF6 Kruppel-like factor 6
KRT13 keratin 13, type I
KRT17 keratin 17, type I
KRT19 keratin 19, type I
KRT5 keratin 5, type II
KRT6B keratin 6B, type II
LDLR low density lipoprotein receptor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MCL1 myeloid cell leukemia 1
MLF1 myeloid leukemia factor 1
MMP7 matrix metallopeptidase 7
MORC4 MORC family CW-type zinc finger 4
MSLN mesothelin
MT1X metallothionein 1X
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYBPC1 myosin binding protein C, slow type
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFIL3 nuclear factor, interleukin 3 regulated
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A3 nuclear receptor subfamily 4, group A, member 3
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
PKP1 plakophilin 1
PLAUR plasminogen activator, urokinase receptor
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RCAN1 regulator of calcineurin 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RND3 Rho family GTPase 3
S100A2 S100 calcium binding protein A2
S100P S100 calcium binding protein P
SDC4 syndecan 4
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SERTAD2 SERTA domain containing 2
SFN stratifin
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD3 SMAD family member 3
SOX9 SRY (sex determining region Y)-box 9
SPAG9 sperm associated antigen 9
SPRR1A small proline-rich protein 1A
SPRR3 small proline-rich protein 3
SPRY2 sprouty homolog 2 (Drosophila)
STK38L serine/threonine kinase 38 like
TES testin LIM domain protein
TGFBI transforming growth factor, beta-induced, 68kDa
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRIB1 tribbles pseudokinase 1
TRIB3 tribbles pseudokinase 3
TUFT1 tuftelin 1
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ASB13 ankyrin repeat and SOCS box containing 13
ATF5 activating transcription factor 5
B3GNT1
BCHE butyrylcholinesterase
C2CD2 C2 calcium-dependent domain containing 2
C3 complement component 3
CANT1 calcium activated nucleotidase 1
CCNA2 cyclin A2
CCNF cyclin F
DEPTOR DEP domain containing MTOR-interacting protein
ERBB3 erb-b2 receptor tyrosine kinase 3
ESR1 estrogen receptor 1
FAM63A family with sequence similarity 63, member A
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GOLM1 golgi membrane protein 1
GPRC5B G protein-coupled receptor, class C, group 5, member B
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFI16 interferon, gamma-inducible protein 16
IGFBP5 insulin-like growth factor binding protein 5
IGHM immunoglobulin heavy constant mu
KIF20A kinesin family member 20A
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MARCKS myristoylated alanine-rich protein kinase C substrate
MCM3 minichromosome maintenance complex component 3
MLEC malectin
MREG melanoregulin
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
POU2AF1 POU class 2 associating factor 1
PRKCD protein kinase C, delta
PSRC1 proline/serine-rich coiled-coil 1
PTTG1 pituitary tumor-transforming 1
SCGB2A2 secretoglobin, family 2A, member 2
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC35E2B solute carrier family 35, member E2B
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPTBN1 spectrin, beta, non-erythrocytic 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TBC1D16 TBC1 domain family, member 16
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TBC1D9B TBC1 domain family, member 9B (with GRAM domain)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNS1 tensin 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIM22 tripartite motif containing 22
TUBB tubulin, beta class I