BRD-A49680073_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

265 genes differentially expressed following the BRD-A49680073_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ACSL1 acyl-CoA synthetase long-chain family member 1
ACTN1 actinin, alpha 1
ADGRG1 adhesion G protein-coupled receptor G1
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANXA3 annexin A3
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BCL3 B-cell CLL/lymphoma 3
BCL6 B-cell CLL/lymphoma 6
BHLHE40 basic helix-loop-helix family, member e40
BTG1 B-cell translocation gene 1, anti-proliferative
C1ORF106 chromosome 1 open reading frame 106
CARS cysteinyl-tRNA synthetase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK7 cyclin-dependent kinase 7
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CENPU centromere protein U
CGRRF1 cell growth regulator with ring finger domain 1
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLIC4 chloride intracellular channel 4
COL9A3 collagen, type IX, alpha 3
COTL1 coactosin-like F-actin binding protein 1
CSF3R colony stimulating factor 3 receptor (granulocyte)
CSRP1 cysteine and glycine-rich protein 1
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DAAM1 dishevelled associated activator of morphogenesis 1
DAPK3 death-associated protein kinase 3
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42
DENND3 DENN/MADD domain containing 3
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EDN1 endothelin 1
EGR1 early growth response 1
ELANE elastase, neutrophil expressed
EPRS glutamyl-prolyl-tRNA synthetase
EREG epiregulin
FAM129A family with sequence similarity 129, member A
FHL2 four and a half LIM domains 2
FLNA filamin A, alpha
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
FOXO1 forkhead box O1
FOXO3 forkhead box O3
G6PD glucose-6-phosphate dehydrogenase
GABPB1 GA binding protein transcription factor, beta subunit 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GARS glycyl-tRNA synthetase
GAS7 growth arrest-specific 7
GDF15 growth differentiation factor 15
GRB10 growth factor receptor-bound protein 10
H1F0 H1 histone family, member 0
H2BFS H2B histone family, member S (pseudogene)
HAL histidine ammonia-lyase
HCAR3 hydroxycarboxylic acid receptor 3
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BK histone cluster 1, H2bk
HMOX1 heme oxygenase 1
HOPX HOP homeobox
ICAM1 intercellular adhesion molecule 1
IER2 immediate early response 2
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IL6R interleukin 6 receptor
ISG20 interferon stimulated exonuclease gene 20kDa
JMJD1C jumonji domain containing 1C
JUN jun proto-oncogene
KCMF1 potassium channel modulatory factor 1
KDM3A lysine (K)-specific demethylase 3A
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KRCC1 lysine-rich coiled-coil 1
KYNU kynureninase
LYST lysosomal trafficking regulator
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MCL1 myeloid cell leukemia 1
MGLL monoglyceride lipase
MICALL1 MICAL-like 1
MPO myeloperoxidase
MSLN mesothelin
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFIL3 nuclear factor, interleukin 3 regulated
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDPK1 3-phosphoinositide dependent protein kinase 1
PELI1 pellino E3 ubiquitin protein ligase 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PFKP phosphofructokinase, platelet
PHGDH phosphoglycerate dehydrogenase
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAU plasminogen activator, urokinase
PLK2 polo-like kinase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPCDC phosphopantothenoylcysteine decarboxylase
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSPC1 paraspeckle component 1
RBMS1 RNA binding motif, single stranded interacting protein 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGCC regulator of cell cycle
RHOB ras homolog family member B
RIOK3 RIO kinase 3
RIPK2 receptor-interacting serine-threonine kinase 2
RNF19B ring finger protein 19B
RRAGD Ras-related GTP binding D
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RSRC2 arginine/serine-rich coiled-coil 2
S100P S100 calcium binding protein P
SAMD4A sterile alpha motif domain containing 4A
SAT1 spermidine/spermine N1-acetyltransferase 1
SERTAD2 SERTA domain containing 2
SETD5 SET domain containing 5
SLC31A2 solute carrier family 31 (copper transporter), member 2
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMOX spermine oxidase
SPAG1 sperm associated antigen 1
SPAG9 sperm associated antigen 9
STK38L serine/threonine kinase 38 like
SYNGR3 synaptogyrin 3
TARS threonyl-tRNA synthetase
TLK2 tousled-like kinase 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TPM1 tropomyosin 1 (alpha)
TREM1 triggering receptor expressed on myeloid cells 1
TRIM16 tripartite motif containing 16
TSC22D2 TSC22 domain family, member 2
TSC22D3 TSC22 domain family, member 3
TUFT1 tuftelin 1
TXNL4B thioredoxin-like 4B
TXNRD1 thioredoxin reductase 1
UBAP1 ubiquitin associated protein 1
VCL vinculin
VEGFA vascular endothelial growth factor A
VWF von Willebrand factor
WARS tryptophanyl-tRNA synthetase
YARS tyrosyl-tRNA synthetase
YBX3 Y box binding protein 3
ZBTB18 zinc finger and BTB domain containing 18
ZCCHC8 zinc finger, CCHC domain containing 8
ZFP36 ZFP36 ring finger protein
ZYX zyxin

decreased expression

Symbol Name
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3
ACAT2 acetyl-CoA acetyltransferase 2
ADD3 adducin 3 (gamma)
ADGRL2 adhesion G protein-coupled receptor L2
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIRF adipogenesis regulatory factor
ANKRD46 ankyrin repeat domain 46
ARMCX1 armadillo repeat containing, X-linked 1
ARMCX2 armadillo repeat containing, X-linked 2
ATF5 activating transcription factor 5
B3GNT1
BCHE butyrylcholinesterase
C3 complement component 3
CA12 carbonic anhydrase XII
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCND1 cyclin D1
CDC25A cell division cycle 25A
CHGB chromogranin B
COL3A1 collagen, type III, alpha 1
COL4A6 collagen, type IV, alpha 6
COL6A3 collagen, type VI, alpha 3
CXCL14 chemokine (C-X-C motif) ligand 14
CYBA cytochrome b-245, alpha polypeptide
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DCN decorin
DPYD dihydropyrimidine dehydrogenase
DPYSL2 dihydropyrimidinase-like 2
DSCC1 DNA replication and sister chromatid cohesion 1
EFNB2 ephrin-B2
ELOVL6 ELOVL fatty acid elongase 6
FCGBP Fc fragment of IgG binding protein
FHL1 four and a half LIM domains 1
FRZB frizzled-related protein
GAL galanin/GMAP prepropeptide
GATA3 GATA binding protein 3
GJA1 gap junction protein, alpha 1, 43kDa
GLUD1 glutamate dehydrogenase 1
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPRASP1 G protein-coupled receptor associated sorting protein 1
GRWD1 glutamate-rich WD repeat containing 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IGFBP5 insulin-like growth factor binding protein 5
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IGLV2-23 immunoglobulin lambda variable 2-23
INSIG1 insulin induced gene 1
IQGAP2 IQ motif containing GTPase activating protein 2
JCHAIN joining chain of multimeric IgA and IgM
KCTD12 potassium channel tetramerization domain containing 12
KRT19 keratin 19, type I
LEPR leptin receptor
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LONP2 lon peptidase 2, peroxisomal
LPAR6 lysophosphatidic acid receptor 6
LRRN3 leucine rich repeat neuronal 3
MAN1A1 mannosidase, alpha, class 1A, member 1
MAT2A methionine adenosyltransferase II, alpha
MBOAT7 membrane bound O-acyltransferase domain containing 7
MDK midkine (neurite growth-promoting factor 2)
MLEC malectin
MPPED2 metallophosphoesterase domain containing 2
MXRA7 matrix-remodelling associated 7
NELL2 NEL-like 2 (chicken)
NMU neuromedin U
NT5DC2 5'-nucleotidase domain containing 2
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11
PCNA proliferating cell nuclear antigen
PDCD2 programmed cell death 2
PEX11A peroxisomal biogenesis factor 11 alpha
PLBD1 phospholipase B domain containing 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
RBP1 retinol binding protein 1, cellular
RBP4 retinol binding protein 4, plasma
RCAN2 regulator of calcineurin 2
RER1 retention in endoplasmic reticulum sorting receptor 1
RGS10 regulator of G-protein signaling 10
RNASE6 ribonuclease, RNase A family, k6
RSRP1 arginine/serine-rich protein 1
SCGB1D2 secretoglobin, family 1D, member 2
SCN3A sodium channel, voltage gated, type III alpha subunit
SDC2 syndecan 2
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SQLE squalene epoxidase
SRGN serglycin
SRSF1 serine/arginine-rich splicing factor 1
TFPI2 tissue factor pathway inhibitor 2
TMEM50B transmembrane protein 50B
TMSB15A thymosin beta 15a
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSPAN13 tetraspanin 13
TUSC3 tumor suppressor candidate 3
VCAM1 vascular cell adhesion molecule 1
VWA5A von Willebrand factor A domain containing 5A
ZNF423 zinc finger protein 423