BRD-A49680073_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

296 genes differentially expressed following the BRD-A49680073_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ACTA1 actin, alpha 1, skeletal muscle
ACVR1 activin A receptor, type I
ADM adrenomedullin
ANXA1 annexin A1
ARL4C ADP-ribosylation factor-like 4C
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
AZIN1 antizyme inhibitor 1
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BTG1 B-cell translocation gene 1, anti-proliferative
C1ORF106 chromosome 1 open reading frame 106
CAPN2 calpain 2, (m/II) large subunit
CAST calpastatin
CBR3 carbonyl reductase 3
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CELF2 CUGBP, Elav-like family member 2
CEMIP cell migration inducing protein, hyaluronan binding
CTH cystathionine gamma-lyase
CTSL cathepsin L
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DPYSL3 dihydropyrimidinase-like 3
DSC2 desmocollin 2
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EIF1 eukaryotic translation initiation factor 1
EIF5 eukaryotic translation initiation factor 5
ELANE elastase, neutrophil expressed
ELF4 E74-like factor 4 (ets domain transcription factor)
EMX2 empty spiracles homeobox 2
EPHA2 EPH receptor A2
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM129A family with sequence similarity 129, member A
FHL2 four and a half LIM domains 2
FNDC3B fibronectin type III domain containing 3B
FNTA farnesyltransferase, CAAX box, alpha
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
FYN FYN proto-oncogene, Src family tyrosine kinase
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
GATA6 GATA binding protein 6
GCLC glutamate-cysteine ligase, catalytic subunit
GDF15 growth differentiation factor 15
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GPR87 G protein-coupled receptor 87
GRB10 growth factor receptor-bound protein 10
HAL histidine ammonia-lyase
HBB hemoglobin, beta
HBEGF heparin-binding EGF-like growth factor
HEPH hephaestin
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IFRD1 interferon-related developmental regulator 1
IL13RA1 interleukin 13 receptor, alpha 1
ITCH itchy E3 ubiquitin protein ligase
JAG1 jagged 1
JUN jun proto-oncogene
KCMF1 potassium channel modulatory factor 1
KDM3A lysine (K)-specific demethylase 3A
KLF10 Kruppel-like factor 10
KLF11 Kruppel-like factor 11
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
LAMB3 laminin, beta 3
LARP6 La ribonucleoprotein domain family, member 6
LYPD1 LY6/PLAUR domain containing 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MAP1B microtubule-associated protein 1B
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MCL1 myeloid cell leukemia 1
MERTK MER proto-oncogene, tyrosine kinase
MICALL1 MICAL-like 1
MIR22HG MIR22 host gene
MME membrane metallo-endopeptidase
MSLN mesothelin
MVP major vault protein
MXI1 MAX interactor 1, dimerization protein
MYO10 myosin X
NFIL3 nuclear factor, interleukin 3 regulated
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDGFA platelet-derived growth factor alpha polypeptide
PELI1 pellino E3 ubiquitin protein ligase 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLIN2 perilipin 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRUNE2 prune homolog 2 (Drosophila)
PSAP prosaposin
PSAT1 phosphoserine aminotransferase 1
PTX3 pentraxin 3, long
RB1CC1 RB1-inducible coiled-coil 1
RBMS1 RNA binding motif, single stranded interacting protein 1
RGCC regulator of cell cycle
RIOK3 RIO kinase 3
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RND3 Rho family GTPase 3
RNF19B ring finger protein 19B
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SARS seryl-tRNA synthetase
SAT1 spermidine/spermine N1-acetyltransferase 1
SDC4 syndecan 4
SH3GLB1 SH3-domain GRB2-like endophilin B1
SH3YL1 SH3 and SYLF domain containing 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPRY2 sprouty homolog 2 (Drosophila)
SQSTM1 sequestosome 1
STAR steroidogenic acute regulatory protein
STK38L serine/threonine kinase 38 like
TAGLN transgelin
TARS threonyl-tRNA synthetase
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TCEA1 transcription elongation factor A (SII), 1
TDO2 tryptophan 2,3-dioxygenase
TES testin LIM domain protein
TGIF1 TGFB-induced factor homeobox 1
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TPM1 tropomyosin 1 (alpha)
TPP1 tripeptidyl peptidase I
TRAM1 translocation associated membrane protein 1
TSC22D3 TSC22 domain family, member 3
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
TXNRD1 thioredoxin reductase 1
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
VGLL4 vestigial-like family member 4
WDR45 WD repeat domain 45
YPEL5 yippee-like 5 (Drosophila)
ZFAND5 zinc finger, AN1-type domain 5
ZYX zyxin

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ACOT7 acyl-CoA thioesterase 7
ANXA9 annexin A9
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ARMT1 acidic residue methyltransferase 1
ASF1B anti-silencing function 1B histone chaperone
AURKA aurora kinase A
B3GNT1
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C3 complement component 3
CA12 carbonic anhydrase XII
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CCNA2 cyclin A2
CCND1 cyclin D1
CCNF cyclin F
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CENPA centromere protein A
CHEK2 checkpoint kinase 2
CTSD cathepsin D
DCXR dicarbonyl/L-xylulose reductase
DHCR24 24-dehydrocholesterol reductase
DHFR dihydrofolate reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUT deoxyuridine triphosphatase
EBP emopamil binding protein (sterol isomerase)
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ELOVL6 ELOVL fatty acid elongase 6
EML3 echinoderm microtubule associated protein like 3
ESR1 estrogen receptor 1
ETFB electron-transfer-flavoprotein, beta polypeptide
EVL Enah/Vasp-like
F12 coagulation factor XII (Hageman factor)
FAM63A family with sequence similarity 63, member A
FANCI Fanconi anemia, complementation group I
FBP1 fructose-1,6-bisphosphatase 1
FEN1 flap structure-specific endonuclease 1
FHL1 four and a half LIM domains 1
GALE UDP-galactose-4-epimerase
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GATA3 GATA binding protein 3
GGCX gamma-glutamyl carboxylase
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPX3 glutathione peroxidase 3
GSTM3 glutathione S-transferase mu 3 (brain)
GTSE1 G-2 and S-phase expressed 1
H2AFX H2A histone family, member X
HIST1H4C histone cluster 1, H4c
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IGFBP6 insulin-like growth factor binding protein 6
INSIG1 insulin induced gene 1
KIAA0101 KIAA0101
KIAA1467 KIAA1467
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
LAGE3 L antigen family, member 3
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MSL1 male-specific lethal 1 homolog (Drosophila)
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NCAPD3 non-SMC condensin II complex, subunit D3
NCAPH non-SMC condensin I complex, subunit H
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa
NDUFB1 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NME4 NME/NM23 nucleoside diphosphate kinase 4
NPY1R neuropeptide Y receptor Y1
NQO1 NAD(P)H dehydrogenase, quinone 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRIP1 nuclear receptor interacting protein 1
NUP210 nucleoporin 210kDa
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PEBP1 phosphatidylethanolamine binding protein 1
PGAM1 phosphoglycerate mutase 1 (brain)
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLK1 polo-like kinase 1
PNKP polynucleotide kinase 3'-phosphatase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PPIH peptidylprolyl isomerase H (cyclophilin H)
PRC1 protein regulator of cytokinesis 1
PRSS23 protease, serine, 23
PTP4A2 protein tyrosine phosphatase type IVA, member 2
PTTG1 pituitary tumor-transforming 1
RAB26 RAB26, member RAS oncogene family
RFC5 replication factor C (activator 1) 5, 36.5kDa
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RPA3 replication protein A3, 14kDa
RPS4Y1 ribosomal protein S4, Y-linked 1
RRM2 ribonucleotide reductase M2
SCARB1 scavenger receptor class B, member 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB2A2 secretoglobin, family 2A, member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFRP1 secreted frizzled-related protein 1
SFRP4 secreted frizzled-related protein 4
SH3GLB2 SH3-domain GRB2-like endophilin B2
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SLIT2 slit homolog 2 (Drosophila)
SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SPDEF SAM pointed domain containing ETS transcription factor
STMN1 stathmin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TMEM97 transmembrane protein 97
TMPO thymopoietin
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOP2A topoisomerase (DNA) II alpha 170kDa
TPD52L1 tumor protein D52-like 1
TRIP13 thyroid hormone receptor interactor 13
TSEN34 TSEN34 tRNA splicing endonuclease subunit
TSPAN13 tetraspanin 13
TSPAN4 tetraspanin 4
TSPAN6 tetraspanin 6
TUBA1A tubulin, alpha 1a
TUBB tubulin, beta class I
TUSC3 tumor suppressor candidate 3
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
ZNF226 zinc finger protein 226
ZWINT ZW10 interacting kinetochore protein