BRD-A49225603_TRIMEPRAZINE TARTRATE_A549_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

81 genes differentially expressed following the BRD-A49225603_TRIMEPRAZINE TARTRATE_A549_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAT2 acetyl-CoA acetyltransferase 2
ALDOC aldolase C, fructose-bisphosphate
AQP1 aquaporin 1 (Colton blood group)
ASS1 argininosuccinate synthase 1
BHLHE41 basic helix-loop-helix family, member e41
CASP10 caspase 10, apoptosis-related cysteine peptidase
CD52 CD52 molecule
CFB complement factor B
CKAP4 cytoskeleton-associated protein 4
CLCA2 chloride channel accessory 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
EBP emopamil binding protein (sterol isomerase)
EGFL6 EGF-like-domain, multiple 6
EHD3 EH-domain containing 3
ELOVL6 ELOVL fatty acid elongase 6
FABP7 fatty acid binding protein 7, brain
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GPNMB glycoprotein (transmembrane) nmb
GPX1 glutathione peroxidase 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HNMT histamine N-methyltransferase
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDI1 isopentenyl-diphosphate delta isomerase 1
INSIG1 insulin induced gene 1
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KRT15 keratin 15, type I
LDLR low density lipoprotein receptor
LUM lumican
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MFAP5 microfibrillar associated protein 5
MME membrane metallo-endopeptidase
MSMO1 methylsterol monooxygenase 1
NDNF neuron-derived neurotrophic factor
NRN1 neuritin 1
NUPR1 nuclear protein, transcriptional regulator, 1
OLFM1 olfactomedin 1
PCP4 Purkinje cell protein 4
PTGIS prostaglandin I2 (prostacyclin) synthase
QPRT quinolinate phosphoribosyltransferase
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
STMN2 stathmin 2
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFF1 trefoil factor 1
TSPAN8 tetraspanin 8
VCAN versican
VSNL1 visinin-like 1

decreased expression

Symbol Name
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANXA1 annexin A1
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ARHGAP29 Rho GTPase activating protein 29
BID BH3 interacting domain death agonist
BOP1 block of proliferation 1
BTG3 BTG family, member 3
C6ORF62 chromosome 6 open reading frame 62
CDC45 cell division cycle 45
CDCA4 cell division cycle associated 4
CLU clusterin
CYCS cytochrome c, somatic
GALC galactosylceramidase
GBP2 guanylate binding protein 2, interferon-inducible
IFI44L interferon-induced protein 44-like
INHBB inhibin, beta B
KLF9 Kruppel-like factor 9
PTPRK protein tyrosine phosphatase, receptor type, K
S100A10 S100 calcium binding protein A10
SDC4 syndecan 4
SMAD3 SMAD family member 3