BRD-A48430263_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

68 genes differentially expressed following the BRD-A48430263_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AHSP alpha hemoglobin stabilizing protein
ALAS2 5'-aminolevulinate synthase 2
CA1 carbonic anhydrase I
CCDC86 coiled-coil domain containing 86
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
EGFR epidermal growth factor receptor
EXT1 exostosin glycosyltransferase 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GNLY granulysin
HBD hemoglobin, delta
IFITM3 interferon induced transmembrane protein 3
IGHM immunoglobulin heavy constant mu
JUN jun proto-oncogene
KRT15 keratin 15, type I
LPAR6 lysophosphatidic acid receptor 6
MMP12 matrix metallopeptidase 12
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NRGN neurogranin (protein kinase C substrate, RC3)
PLBD1 phospholipase B domain containing 1
RFTN1 raftlin, lipid raft linker 1
RGCC regulator of cell cycle
RTN1 reticulon 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group)
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
TACSTD2 tumor-associated calcium signal transducer 2
WDR7 WD repeat domain 7
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEMIP cell migration inducing protein, hyaluronan binding
CHMP4A charged multivesicular body protein 4A
CXCL12 chemokine (C-X-C motif) ligand 12
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLD dihydrolipoamide dehydrogenase
EDNRB endothelin receptor type B
FABP5 fatty acid binding protein 5 (psoriasis-associated)
GAL galanin/GMAP prepropeptide
GLDC glycine dehydrogenase (decarboxylating)
GPRC5B G protein-coupled receptor, class C, group 5, member B
GPX2 glutathione peroxidase 2
GPX3 glutathione peroxidase 3
HEXIM1 hexamethylene bis-acetamide inducible 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IGFBP3 insulin-like growth factor binding protein 3
KIF14 kinesin family member 14
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MLF1 myeloid leukemia factor 1
PCDH9 protocadherin 9
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PNMA1 paraneoplastic Ma antigen 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
RCAN1 regulator of calcineurin 1
RPS27L ribosomal protein S27-like
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
TFF1 trefoil factor 1
TNC tenascin C
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
WDTC1 WD and tetratricopeptide repeats 1