BRD-A48237631_MITOMYCIN C_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

165 genes differentially expressed following the BRD-A48237631_MITOMYCIN C_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ANKRD10 ankyrin repeat domain 10
ANXA4 annexin A4
AREG amphiregulin
ATF3 activating transcription factor 3
BTG2 BTG family, member 2
BTG3 BTG family, member 3
C3 complement component 3
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CASP8 caspase 8, apoptosis-related cysteine peptidase
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CKB creatine kinase, brain
CXADR coxsackie virus and adenovirus receptor
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL8 chemokine (C-X-C motif) ligand 8
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT4 DNA-damage-inducible transcript 4
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
DUSP3 dual specificity phosphatase 3
EGR2 early growth response 2
EMP1 epithelial membrane protein 1
FAS Fas cell surface death receptor
FDXR ferredoxin reductase
FHL1 four and a half LIM domains 1
FOSL1 FOS-like antigen 1
FUCA1 fucosidase, alpha-L- 1, tissue
GADD45A growth arrest and DNA-damage-inducible, alpha
GPX1 glutathione peroxidase 1
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-F major histocompatibility complex, class I, F
HLA-G major histocompatibility complex, class I, G
IER5 immediate early response 5
IL1R2 interleukin 1 receptor, type II
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
JAG1 jagged 1
KLF4 Kruppel-like factor 4 (gut)
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LMNA lamin A/C
LY86 lymphocyte antigen 86
MAOA monoamine oxidase A
MIR22HG MIR22 host gene
MMP12 matrix metallopeptidase 12
NT5E 5'-nucleotidase, ecto (CD73)
PHLDA2 pleckstrin homology-like domain, family A, member 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPIF peptidylprolyl isomerase F
PRNP prion protein
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RGCC regulator of cell cycle
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SESN1 sestrin 1
SFN stratifin
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRGN serglycin
TIMP1 TIMP metallopeptidase inhibitor 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM5 transmembrane protein 5
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TRIM22 tripartite motif containing 22
TXNL4B thioredoxin-like 4B
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VIM vimentin
ZDHHC4 zinc finger, DHHC-type containing 4
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACSL3 acyl-CoA synthetase long-chain family member 3
ADGRG6 adhesion G protein-coupled receptor G6
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
ALPL alkaline phosphatase, liver/bone/kidney
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
AQP3 aquaporin 3 (Gill blood group)
ARID4B AT rich interactive domain 4B (RBP1-like)
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATP9A ATPase, class II, type 9A
AURKA aurora kinase A
AUTS2 autism susceptibility candidate 2
BAMBI BMP and activin membrane-bound inhibitor
CA12 carbonic anhydrase XII
CCNF cyclin F
CDK17 cyclin-dependent kinase 17
CDK19 cyclin-dependent kinase 19
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CEP350 centrosomal protein 350kDa
CHD7 chromodomain helicase DNA binding protein 7
CHD9 chromodomain helicase DNA binding protein 9
CIT citron rho-interacting serine/threonine kinase
COL9A3 collagen, type IX, alpha 3
CUX1 cut-like homeobox 1
CXCL12 chemokine (C-X-C motif) ligand 12
CYB5A cytochrome b5 type A (microsomal)
DACH1 dachshund family transcription factor 1
DENND1B DENN/MADD domain containing 1B
DLC1 DLC1 Rho GTPase activating protein
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DOCK4 dedicator of cytokinesis 4
FGF13 fibroblast growth factor 13
GABPB1 GA binding protein transcription factor, beta subunit 1
GATA3 GATA binding protein 3
HAS2 hyaluronan synthase 2
HIST1H2BG histone cluster 1, H2bg
HIST1H4C histone cluster 1, H4c
HOXC10 homeobox C10
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA1A heat shock 70kDa protein 1A
IGF1R insulin-like growth factor 1 receptor
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
IRX5 iroquois homeobox 5
JADE2 jade family PHD finger 2
JARID2 jumonji, AT rich interactive domain 2
KANK1 KN motif and ankyrin repeat domains 1
KIF14 kinesin family member 14
LOC100272216 uncharacterized LOC100272216
MAP2K5 mitogen-activated protein kinase kinase 5
MAP7 microtubule-associated protein 7
MAST4 microtubule associated serine/threonine kinase family member 4
MBNL2 muscleblind-like splicing regulator 2
MEGF9 multiple EGF-like-domains 9
MELK maternal embryonic leucine zipper kinase
MGLL monoglyceride lipase
MNAT1 MNAT CDK-activating kinase assembly factor 1
MTSS1 metastasis suppressor 1
MYO6 myosin VI
NAV2 neuron navigator 2
NCOA1 nuclear receptor coactivator 1
NCOA2 nuclear receptor coactivator 2
NCOA3 nuclear receptor coactivator 3
NDE1 nudE neurodevelopment protein 1
NFIB nuclear factor I/B
NRIP1 nuclear receptor interacting protein 1
PDZRN3 PDZ domain containing ring finger 3
PLK1 polo-like kinase 1
PSRC1 proline/serine-rich coiled-coil 1
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
PXDN peroxidasin
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RHOBTB3 Rho-related BTB domain containing 3
RYBP RING1 and YY1 binding protein
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SIX1 SIX homeobox 1
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SMAD3 SMAD family member 3
SOX4 SRY (sex determining region Y)-box 4
SPDEF SAM pointed domain containing ETS transcription factor
TCF4 transcription factor 4
TIAM1 T-cell lymphoma invasion and metastasis 1
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIM24 tripartite motif containing 24
TRPS1 trichorhinophalangeal syndrome I
TTC28 tetratricopeptide repeat domain 28
VGLL4 vestigial-like family member 4
XIST X inactive specific transcript (non-protein coding)
XYLT1 xylosyltransferase I
ZIC1 Zic family member 1