BRD-A47832959_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

55 genes differentially expressed following the BRD-A47832959_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
CA2 carbonic anhydrase II
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLC Charcot-Leyden crystal galectin
CTSK cathepsin K
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DRAM1 DNA-damage regulated autophagy modulator 1
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
FCN1 ficolin (collagen/fibrinogen domain containing) 1
FTH1 ferritin, heavy polypeptide 1
IFI30 interferon, gamma-inducible protein 30
LDOC1 leucine zipper, down-regulated in cancer 1
MAP7 microtubule-associated protein 7
MEST mesoderm specific transcript
MMP12 matrix metallopeptidase 12
NCF2 neutrophil cytosolic factor 2
NEB nebulin
PDLIM3 PDZ and LIM domain 3
QPCT glutaminyl-peptide cyclotransferase
RTN2 reticulon 2
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SCN3A sodium channel, voltage gated, type III alpha subunit
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
STC2 stanniocalcin 2
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TNNT1 troponin T type 1 (skeletal, slow)
VNN1 vanin 1

decreased expression

Symbol Name
C3 complement component 3
CCND1 cyclin D1
CTSC cathepsin C
EGFR epidermal growth factor receptor
EHBP1 EH domain binding protein 1
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
IGF1R insulin-like growth factor 1 receptor
IGFBP3 insulin-like growth factor binding protein 3
INTS3 integrator complex subunit 3
KIF14 kinesin family member 14
MACF1 microtubule-actin crosslinking factor 1
MECOM MDS1 and EVI1 complex locus
METTL7A methyltransferase like 7A
MKI67 marker of proliferation Ki-67
NRIP1 nuclear receptor interacting protein 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PKN2 protein kinase N2
PLS3 plastin 3
RCN1 reticulocalbin 1, EF-hand calcium binding domain
SCYL3 SCY1-like 3 (S. cerevisiae)
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SFRP1 secreted frizzled-related protein 1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SRPX sushi-repeat containing protein, X-linked
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
WFDC2 WAP four-disulfide core domain 2