BRD-A47829399_artesunate_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

159 genes differentially expressed following the BRD-A47829399_artesunate_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ADAMDEC1 ADAM-like, decysin 1
ALAS1 5'-aminolevulinate synthase 1
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARMCX2 armadillo repeat containing, X-linked 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
CBS cystathionine-beta-synthase
CCPG1 cell cycle progression 1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEMIP cell migration inducing protein, hyaluronan binding
CHGB chromogranin B
CTH cystathionine gamma-lyase
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
EGFR epidermal growth factor receptor
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EPAS1 endothelial PAS domain protein 1
FBN2 fibrillin 2
FKBP11 FK506 binding protein 11, 19 kDa
GADD45A growth arrest and DNA-damage-inducible, alpha
GAGE3 G antigen 3
GARS glycyl-tRNA synthetase
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GPM6B glycoprotein M6B
GRB10 growth factor receptor-bound protein 10
GTPBP2 GTP binding protein 2
HMOX1 heme oxygenase 1
IER3 immediate early response 3
IFI27 interferon, alpha-inducible protein 27
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
LGALS4 lectin, galactoside-binding, soluble, 4
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MARS methionyl-tRNA synthetase
MMP1 matrix metallopeptidase 1
MMP3 matrix metallopeptidase 3
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NUPR1 nuclear protein, transcriptional regulator, 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDGFA platelet-derived growth factor alpha polypeptide
PHGDH phosphoglycerate dehydrogenase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PSAT1 phosphoserine aminotransferase 1
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PYCR1 pyrroline-5-carboxylate reductase 1
REG1A regenerating islet-derived 1 alpha
RGS5 regulator of G-protein signaling 5
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RSL24D1 ribosomal L24 domain containing 1
SCG5 secretogranin V
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC38A1 solute carrier family 38, member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
STC2 stanniocalcin 2
TCEA1 transcription elongation factor A (SII), 1
THBD thrombomodulin
TOX3 TOX high mobility group box family member 3
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRIB3 tribbles pseudokinase 3
TUFT1 tuftelin 1
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
WIPI1 WD repeat domain, phosphoinositide interacting 1
XBP1 X-box binding protein 1
XPOT exportin, tRNA
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
AIM1 absent in melanoma 1
ANKRD10 ankyrin repeat domain 10
ATAD2 ATPase family, AAA domain containing 2
B3GNT1
BAG3 BCL2-associated athanogene 3
BIRC5 baculoviral IAP repeat containing 5
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CBR3 carbonyl reductase 3
CCND3 cyclin D3
CCNE2 cyclin E2
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CRYZ crystallin, zeta (quinone reductase)
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DHFR dihydrofolate reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EBP emopamil binding protein (sterol isomerase)
EGR3 early growth response 3
ENO1 enolase 1, (alpha)
F12 coagulation factor XII (Hageman factor)
FBLN1 fibulin 1
FEN1 flap structure-specific endonuclease 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GMNN geminin, DNA replication inhibitor
GPI glucose-6-phosphate isomerase
GPX3 glutathione peroxidase 3
HOXA10 homeobox A10
HSPA8 heat shock 70kDa protein 8
HSPB8 heat shock 22kDa protein 8
ICMT isoprenylcysteine carboxyl methyltransferase
IGF1 insulin-like growth factor 1 (somatomedin C)
IL27RA interleukin 27 receptor, alpha
KCTD12 potassium channel tetramerization domain containing 12
KIAA0101 KIAA0101
KIF20A kinesin family member 20A
LMNB1 lamin B1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MRPS12 mitochondrial ribosomal protein S12
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MYB v-myb avian myeloblastosis viral oncogene homolog
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAPD3 non-SMC condensin II complex, subunit D3
NR2F2 nuclear receptor subfamily 2, group F, member 2
PCNA proliferating cell nuclear antigen
PFKP phosphofructokinase, platelet
PTDSS1 phosphatidylserine synthase 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SORD sorbitol dehydrogenase
SOX4 SRY (sex determining region Y)-box 4
SPDEF SAM pointed domain containing ETS transcription factor
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
STIP1 stress-induced phosphoprotein 1
STMN1 stathmin 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFDP1 transcription factor Dp-1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGM2 transglutaminase 2
TK1 thymidine kinase 1, soluble
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TUBB tubulin, beta class I
TYMS thymidylate synthetase
VCAN versican
WWTR1 WW domain containing transcription regulator 1
ZBTB18 zinc finger and BTB domain containing 18
ZWINT ZW10 interacting kinetochore protein