BRD-A47816767_-666_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

175 genes differentially expressed following the BRD-A47816767_-666_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ADM adrenomedullin
ALDOC aldolase C, fructose-bisphosphate
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANXA3 annexin A3
AQP1 aquaporin 1 (Colton blood group)
AREG amphiregulin
ATF3 activating transcription factor 3
BHLHE40 basic helix-loop-helix family, member e40
BIRC3 baculoviral IAP repeat containing 3
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CADM1 cell adhesion molecule 1
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHIC2 cysteine-rich hydrophobic domain 2
CLEC5A C-type lectin domain family 5, member A
CSRP2 cysteine and glycine-rich protein 2
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DSG3 desmoglein 3
EGFR epidermal growth factor receptor
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EMP1 epithelial membrane protein 1
ERO1L ERO1-like (S. cerevisiae)
FADS2 fatty acid desaturase 2
FAM107A family with sequence similarity 107, member A
FAM46A family with sequence similarity 46, member A
FN1 fibronectin 1
FXYD6 FXYD domain containing ion transport regulator 6
GADD45A growth arrest and DNA-damage-inducible, alpha
GEM GTP binding protein overexpressed in skeletal muscle
GPX3 glutathione peroxidase 3
HBEGF heparin-binding EGF-like growth factor
HBP1 HMG-box transcription factor 1
HILPDA hypoxia inducible lipid droplet-associated
HK2 hexokinase 2
IER3 immediate early response 3
IGFBP3 insulin-like growth factor binding protein 3
IGL immunoglobulin lambda locus
IL1RN interleukin 1 receptor antagonist
INHBA inhibin, beta A
KDM3A lysine (K)-specific demethylase 3A
KDM5D lysine (K)-specific demethylase 5D
KLF6 Kruppel-like factor 6
KLF7 Kruppel-like factor 7 (ubiquitous)
KLHL24 kelch-like family member 24
KLK10 kallikrein-related peptidase 10
KRT6A keratin 6A, type II
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFIL3 nuclear factor, interleukin 3 regulated
NPC1 Niemann-Pick disease, type C1
OXSR1 oxidative stress responsive 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PCDH17 protocadherin 17
PELI1 pellino E3 ubiquitin protein ligase 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHGDH phosphoglycerate dehydrogenase
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PLAU plasminogen activator, urokinase
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPARD peroxisome proliferator-activated receptor delta
PTN pleiotrophin
PTX3 pentraxin 3, long
QKI QKI, KH domain containing, RNA binding
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RGCC regulator of cell cycle
RPS4Y1 ribosomal protein S4, Y-linked 1
S100P S100 calcium binding protein P
SERINC5 serine incorporator 5
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SIK3 SIK family kinase 3
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLPI secretory leukocyte peptidase inhibitor
SOX4 SRY (sex determining region Y)-box 4
TFF3 trefoil factor 3 (intestinal)
THBD thrombomodulin
THBS1 thrombospondin 1
TIMP3 TIMP metallopeptidase inhibitor 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMBIM1 transmembrane BAX inhibitor motif containing 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNIP1 TNFAIP3 interacting protein 1
TP53BP2 tumor protein p53 binding protein 2
TUFT1 tuftelin 1
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A

decreased expression

Symbol Name
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
AKAP7 A kinase (PRKA) anchor protein 7
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATR ATR serine/threonine kinase
AURKA aurora kinase A
BORA bora, aurora kinase A activator
C14ORF169 chromosome 14 open reading frame 169
C2CD5 C2 calcium-dependent domain containing 5
C6ORF62 chromosome 6 open reading frame 62
CBR1 carbonyl reductase 1
CCL19 chemokine (C-C motif) ligand 19
CCNA2 cyclin A2
CCNB2 cyclin B2
CDC25B cell division cycle 25B
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CEP55 centrosomal protein 55kDa
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CKS2 CDC28 protein kinase regulatory subunit 2
CXCL12 chemokine (C-X-C motif) ligand 12
CYCS cytochrome c, somatic
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAAF2 dynein, axonemal, assembly factor 2
DUSP4 dual specificity phosphatase 4
FASTKD1 FAST kinase domains 1
FBXO11 F-box protein 11
FXYD2 FXYD domain containing ion transport regulator 2
HEATR1 HEAT repeat containing 1
HIST1H2BK histone cluster 1, H2bk
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGA2 high mobility group AT-hook 2
HMGN3 high mobility group nucleosomal binding domain 3
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOXA10 homeobox A10
HOXC6 homeobox C6
HSPA1A heat shock 70kDa protein 1A
IFRD2 interferon-related developmental regulator 2
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LONP2 lon peptidase 2, peroxisomal
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LYZ lysozyme
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MLPH melanophilin
MRPL3 mitochondrial ribosomal protein L3
MRPS31 mitochondrial ribosomal protein S31
MRPS35 mitochondrial ribosomal protein S35
MTERF3 mitochondrial transcription termination factor 3
NEFH neurofilament, heavy polypeptide
NEK2 NIMA-related kinase 2
NIP7 NIP7, nucleolar pre-rRNA processing protein
NOL11 nucleolar protein 11
NOP16 NOP16 nucleolar protein
NT5DC2 5'-nucleotidase domain containing 2
ODC1 ornithine decarboxylase 1
PARP2 poly (ADP-ribose) polymerase 2
PLK1 polo-like kinase 1
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae)
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
RANBP6 RAN binding protein 6
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RPP40 ribonuclease P/MRP 40kDa subunit
RPS11 ribosomal protein S11
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SLC38A1 solute carrier family 38, member 1
SNRPE small nuclear ribonucleoprotein polypeptide E
SRSF7 serine/arginine-rich splicing factor 7
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
TFB2M transcription factor B2, mitochondrial
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TMEM5 transmembrane protein 5
TOM1L1 target of myb1 (chicken)-like 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIB2 tribbles pseudokinase 2
TSEN2 TSEN2 tRNA splicing endonuclease subunit
UBE2S ubiquitin-conjugating enzyme E2S
UBE3C ubiquitin protein ligase E3C
WDR12 WD repeat domain 12
XIST X inactive specific transcript (non-protein coding)