BRD-A47816767_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

128 genes differentially expressed following the BRD-A47816767_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABHD4 abhydrolase domain containing 4
ADM adrenomedullin
AK4 adenylate kinase 4
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C3 aldo-keto reductase family 1, member C3
ALDOC aldolase C, fructose-bisphosphate
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BHLHE40 basic helix-loop-helix family, member e40
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CFD complement factor D (adipsin)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CKB creatine kinase, brain
CLU clusterin
COL6A2 collagen, type VI, alpha 2
COMP cartilage oligomeric matrix protein
CPA3 carboxypeptidase A3 (mast cell)
CRYAB crystallin, alpha B
CTH cystathionine gamma-lyase
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DPYSL3 dihydropyrimidinase-like 3
DUSP3 dual specificity phosphatase 3
DUSP5 dual specificity phosphatase 5
EGLN3 egl-9 family hypoxia-inducible factor 3
FAM162A family with sequence similarity 162, member A
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45B growth arrest and DNA-damage-inducible, beta
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GBE1 glucan (1,4-alpha-), branching enzyme 1
GLRX glutaredoxin (thioltransferase)
GPX2 glutathione peroxidase 2
GSTM3 glutathione S-transferase mu 3 (brain)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HK2 hexokinase 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFI27 interferon, alpha-inducible protein 27
INSIG1 insulin induced gene 1
JUN jun proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KLF10 Kruppel-like factor 10
LOXL2 lysyl oxidase-like 2
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MT1F metallothionein 1F
MT1HL1 metallothionein 1H-like 1
MT1M metallothionein 1M
MT1X metallothionein 1X
MXI1 MAX interactor 1, dimerization protein
NAMPT nicotinamide phosphoribosyltransferase
NDRG1 N-myc downstream regulated 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFIL3 nuclear factor, interleukin 3 regulated
NRIP3 nuclear receptor interacting protein 3
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PDE4D phosphodiesterase 4D, cAMP-specific
PGK1 phosphoglycerate kinase 1
PGM1 phosphoglucomutase 1
PIR pirin (iron-binding nuclear protein)
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRUNE2 prune homolog 2 (Drosophila)
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RHOB ras homolog family member B
RIOK3 RIO kinase 3
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
S100P S100 calcium binding protein P
SCG5 secretogranin V
SIK1 salt-inducible kinase 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPAG4 sperm associated antigen 4
TGFBI transforming growth factor, beta-induced, 68kDa
TSC22D3 TSC22 domain family, member 3
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A

decreased expression

Symbol Name
AIM1 absent in melanoma 1
APLP2 amyloid beta (A4) precursor-like protein 2
APOA2 apolipoprotein A-II
CRISP3 cysteine-rich secretory protein 3
CSTA cystatin A (stefin A)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
ESR1 estrogen receptor 1
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FBP1 fructose-1,6-bisphosphatase 1
GATA3 GATA binding protein 3
GRIA2 glutamate receptor, ionotropic, AMPA 2
HNMT histamine N-methyltransferase
IRS1 insulin receptor substrate 1
KRT14 keratin 14, type I
KRT15 keratin 15, type I
LTF lactotransferrin
MREG melanoregulin
PDLIM5 PDZ and LIM domain 5
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SPDEF SAM pointed domain containing ETS transcription factor
TACSTD2 tumor-associated calcium signal transducer 2
TBC1D4 TBC1 domain family, member 4
TFF1 trefoil factor 1
TNC tenascin C
TRPS1 trichorhinophalangeal syndrome I
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
WEE1 WEE1 G2 checkpoint kinase