BRD-A47816767_-666_HA1E_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

304 genes differentially expressed following the BRD-A47816767_-666_HA1E_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ACADVL acyl-CoA dehydrogenase, very long chain
ACKR3 atypical chemokine receptor 3
ADRB2 adrenoceptor beta 2, surface
ALDOC aldolase C, fructose-bisphosphate
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
APLP2 amyloid beta (A4) precursor-like protein 2
AREG amphiregulin
ARHGAP32 Rho GTPase activating protein 32
ATF3 activating transcription factor 3
BCL6 B-cell CLL/lymphoma 6
BHLHE41 basic helix-loop-helix family, member e41
BMP2 bone morphogenetic protein 2
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
C1ORF106 chromosome 1 open reading frame 106
C3ORF14 chromosome 3 open reading frame 14
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CASP1 caspase 1, apoptosis-related cysteine peptidase
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCL20 chemokine (C-C motif) ligand 20
CCND2 cyclin D2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CES2 carboxylesterase 2
CHIC2 cysteine-rich hydrophobic domain 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLDN3 claudin 3
CLEC2B C-type lectin domain family 2, member B
COL8A2 collagen, type VIII, alpha 2
CPB1 carboxypeptidase B1 (tissue)
CPE carboxypeptidase E
CPQ carboxypeptidase Q
CRISP3 cysteine-rich secretory protein 3
CRYAB crystallin, alpha B
CSTA cystatin A (stefin A)
CTSK cathepsin K
CXCL9 chemokine (C-X-C motif) ligand 9
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT3 DNA-damage-inducible transcript 3
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DLGAP4 discs, large (Drosophila) homolog-associated protein 4
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DSP desmoplakin
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EMX2 empty spiracles homeobox 2
ENO2 enolase 2 (gamma, neuronal)
ERO1L ERO1-like (S. cerevisiae)
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FAS Fas cell surface death receptor
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FILIP1L filamin A interacting protein 1-like
FOXJ3 forkhead box J3
FST follistatin
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GALE UDP-galactose-4-epimerase
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GDF15 growth differentiation factor 15
GGT1 gamma-glutamyltransferase 1
GOLGA8B golgin A8 family, member B
GPI glucose-6-phosphate isomerase
GREM1 gremlin 1, DAN family BMP antagonist
GSN gelsolin
HECA headcase homolog (Drosophila)
HES1 hes family bHLH transcription factor 1
HILPDA hypoxia inducible lipid droplet-associated
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2
HK2 hexokinase 2
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HSPA4L heat shock 70kDa protein 4-like
HSPB8 heat shock 22kDa protein 8
IDO1 indoleamine 2,3-dioxygenase 1
IER5 immediate early response 5
INPP1 inositol polyphosphate-1-phosphatase
INSM1 insulinoma-associated 1
ITM2A integral membrane protein 2A
IVNS1ABP influenza virus NS1A binding protein
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KLF4 Kruppel-like factor 4 (gut)
KLF5 Kruppel-like factor 5 (intestinal)
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
KRT14 keratin 14, type I
KRT5 keratin 5, type II
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LYZ lysozyme
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MFAP5 microfibrillar associated protein 5
MKRN1 makorin ring finger protein 1
MME membrane metallo-endopeptidase
MN1 meningioma (disrupted in balanced translocation) 1
MTUS1 microtubule associated tumor suppressor 1
MXI1 MAX interactor 1, dimerization protein
NDRG1 N-myc downstream regulated 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NPC1 Niemann-Pick disease, type C1
NUPR1 nuclear protein, transcriptional regulator, 1
OLFML2A olfactomedin-like 2A
OSER1 oxidative stress responsive serine-rich 1
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PEG3 paternally expressed 3
PELI1 pellino E3 ubiquitin protein ligase 1
PHACTR2 phosphatase and actin regulator 2
PLXNB2 plexin B2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POMZP3 POM121 and ZP3 fusion
PPL periplakin
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRUNE2 prune homolog 2 (Drosophila)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTHLH parathyroid hormone-like hormone
RALGDS ral guanine nucleotide dissociation stimulator
RAP1GAP2 RAP1 GTPase activating protein 2
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RIOK3 RIO kinase 3
RPS4Y1 ribosomal protein S4, Y-linked 1
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
RRAGD Ras-related GTP binding D
RSRC2 arginine/serine-rich coiled-coil 2
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG5 secretogranin V
SDC4 syndecan 4
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SESN1 sestrin 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPAG4 sperm associated antigen 4
SPRY2 sprouty homolog 2 (Drosophila)
STAMBP STAM binding protein
STC1 stanniocalcin 1
STK10 serine/threonine kinase 10
STX3 syntaxin 3
TCEAL2 transcription elongation factor A (SII)-like 2
TFF3 trefoil factor 3 (intestinal)
TGFA transforming growth factor, alpha
TMEM30B transmembrane protein 30B
TMEM47 transmembrane protein 47
TOX3 TOX high mobility group box family member 3
TP63 tumor protein p63
TPD52 tumor protein D52
TSC22D3 TSC22 domain family, member 3
TTC17 tetratricopeptide repeat domain 17
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
VLDLR very low density lipoprotein receptor
WARS tryptophanyl-tRNA synthetase
WDTC1 WD and tetratricopeptide repeats 1
WSB1 WD repeat and SOCS box containing 1
ZFPM2 zinc finger protein, FOG family member 2

decreased expression

Symbol Name
ALCAM activated leukocyte cell adhesion molecule
ARF4 ADP-ribosylation factor 4
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ARMCX2 armadillo repeat containing, X-linked 2
ASF1A anti-silencing function 1A histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATMIN ATM interactor
ATP5C1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
BMI1 BMI1 proto-oncogene, polycomb ring finger
BST2 bone marrow stromal cell antigen 2
CALR calreticulin
CBR1 carbonyl reductase 1
CBX3 chromobox homolog 3
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CCNB1 cyclin B1
CCNB2 cyclin B2
CCND1 cyclin D1
CD58 CD58 molecule
CD59 CD59 molecule, complement regulatory protein
CDC123 cell division cycle 123
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CDCA3 cell division cycle associated 3
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPB centromere protein B, 80kDa
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CEP55 centrosomal protein 55kDa
CETN2 centrin, EF-hand protein, 2
CIRBP cold inducible RNA binding protein
CKAP2 cytoskeleton associated protein 2
CKS2 CDC28 protein kinase regulatory subunit 2
CNN3 calponin 3, acidic
COMMD3 COMM domain containing 3
CRYZ crystallin, zeta (quinone reductase)
DEPDC1 DEP domain containing 1
DHCR24 24-dehydrocholesterol reductase
DKC1 dyskeratosis congenita 1, dyskerin
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DPYSL2 dihydropyrimidinase-like 2
DSTN destrin (actin depolymerizing factor)
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ELOVL6 ELOVL fatty acid elongase 6
EPN2 epsin 2
EXTL2 exostosin-like glycosyltransferase 2
FADD Fas (TNFRSF6)-associated via death domain
FAM171A1 family with sequence similarity 171, member A1
FAM35A family with sequence similarity 35, member A
FAM64A family with sequence similarity 64, member A
FASTKD5 FAST kinase domains 5
FBXO9 F-box protein 9
FKBP1A FK506 binding protein 1A, 12kDa
GDI2 GDP dissociation inhibitor 2
GLIPR1 GLI pathogenesis-related 1
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
GRWD1 glutamate-rich WD repeat containing 1
H2BFS H2B histone family, member S (pseudogene)
HDAC2 histone deacetylase 2
HIST1H2AC histone cluster 1, H2ac
HIST1H2BK histone cluster 1, H2bk
HMGB3 high mobility group box 3
HMMR hyaluronan-mediated motility receptor (RHAMM)
HN1 hematological and neurological expressed 1
HNMT histamine N-methyltransferase
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3
HOXA10 homeobox A10
HOXA5 homeobox A5
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPA14 heat shock 70kDa protein 14
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGFBP1 insulin-like growth factor binding protein 1
IGFBP4 insulin-like growth factor binding protein 4
IL1R1 interleukin 1 receptor, type I
JADE2 jade family PHD finger 2
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF2C kinesin family member 2C
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LBR lamin B receptor
LDLR low density lipoprotein receptor
LIPA lipase A, lysosomal acid, cholesterol esterase
LSM1 LSM1, U6 small nuclear RNA associated
MAGED1 melanoma antigen family D1
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MAT2A methionine adenosyltransferase II, alpha
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MPZL1 myelin protein zero-like 1
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NOP56 NOP56 ribonucleoprotein
NPY1R neuropeptide Y receptor Y1
NQO1 NAD(P)H dehydrogenase, quinone 1
NT5DC2 5'-nucleotidase domain containing 2
NUP62 nucleoporin 62kDa
PAIP1 poly(A) binding protein interacting protein 1
PBK PDZ binding kinase
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POSTN periostin, osteoblast specific factor
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
PSRC1 proline/serine-rich coiled-coil 1
PTP4A2 protein tyrosine phosphatase type IVA, member 2
RIN2 Ras and Rab interactor 2
RPP40 ribonuclease P/MRP 40kDa subunit
RUVBL1 RuvB-like AAA ATPase 1
SACM1L SAC1 suppressor of actin mutations 1-like (yeast)
SEPHS1 selenophosphate synthetase 1
SHCBP1 SHC SH2-domain binding protein 1
SKP1 S-phase kinase-associated protein 1
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
SORD sorbitol dehydrogenase
SRSF1 serine/arginine-rich splicing factor 1
SRSF2 serine/arginine-rich splicing factor 2
SRSF3 serine/arginine-rich splicing factor 3
STMN1 stathmin 1
SUB1 SUB1 homolog (S. cerevisiae)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TCF4 transcription factor 4
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TIMM17A translocase of inner mitochondrial membrane 17 homolog A (yeast)
TM4SF1 transmembrane 4 L six family member 1
TMEM14A transmembrane protein 14A
TMEM243 transmembrane protein 243, mitochondrial
TOP2A topoisomerase (DNA) II alpha 170kDa
TRAK2 trafficking protein, kinesin binding 2
TXNDC9 thioredoxin domain containing 9
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
WDR77 WD repeat domain 77
WNT5A wingless-type MMTV integration site family, member 5A
WRB tryptophan rich basic protein