BRD-A47816767_-666_A549_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

148 genes differentially expressed following the BRD-A47816767_-666_A549_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADD3 adducin 3 (gamma)
ADIRF adipogenesis regulatory factor
AK4 adenylate kinase 4
AKR1C3 aldo-keto reductase family 1, member C3
ALB albumin
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
ALDOC aldolase C, fructose-bisphosphate
APOD apolipoprotein D
AREG amphiregulin
C14ORF132 chromosome 14 open reading frame 132
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
C5 complement component 5
CA2 carbonic anhydrase II
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CBS cystathionine-beta-synthase
CCDC92 coiled-coil domain containing 92
CCNI cyclin I
CCR2 chemokine (C-C motif) receptor 2
CD14 CD14 molecule
CLIC3 chloride intracellular channel 3
CLMN calmin (calponin-like, transmembrane)
CTSH cathepsin H
CYBB cytochrome b-245, beta polypeptide
DCN decorin
DDR2 discoidin domain receptor tyrosine kinase 2
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DSG2 desmoglein 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EVI2A ecotropic viral integration site 2A
FHL2 four and a half LIM domains 2
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FSTL1 follistatin-like 1
GBP2 guanylate binding protein 2, interferon-inducible
GPX2 glutathione peroxidase 2
GSTM2 glutathione S-transferase mu 2 (muscle)
GSTT1 glutathione S-transferase theta 1
GSTZ1 glutathione S-transferase zeta 1
GUSB glucuronidase, beta
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IGFBP5 insulin-like growth factor binding protein 5
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KDM5D lysine (K)-specific demethylase 5D
KDM7A lysine (K)-specific demethylase 7A
KLF6 Kruppel-like factor 6
LARP6 La ribonucleoprotein domain family, member 6
LGALS4 lectin, galactoside-binding, soluble, 4
MMP12 matrix metallopeptidase 12
MSRB2 methionine sulfoxide reductase B2
MYLK myosin light chain kinase
MYRF myelin regulatory factor
NEBL nebulette
NUPR1 nuclear protein, transcriptional regulator, 1
OLFM4 olfactomedin 4
OPTN optineurin
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDGFA platelet-derived growth factor alpha polypeptide
PGLS 6-phosphogluconolactonase
PHGDH phosphoglycerate dehydrogenase
PHYH phytanoyl-CoA 2-hydroxylase
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PPAP2B phosphatidic acid phosphatase type 2B
PSAT1 phosphoserine aminotransferase 1
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RAB15 RAB15, member RAS oncogene family
RAB31 RAB31, member RAS oncogene family
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RHOBTB3 Rho-related BTB domain containing 3
RNASE6 ribonuclease, RNase A family, k6
RPS5 ribosomal protein S5
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SKAP2 src kinase associated phosphoprotein 2
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SPINK1 serine peptidase inhibitor, Kazal type 1
SRSF6 serine/arginine-rich splicing factor 6
STC2 stanniocalcin 2
SYNJ2 synaptojanin 2
TAGLN transgelin
TBX2 T-box 2
TF transferrin
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TMEM47 transmembrane protein 47
TP53 tumor protein p53
TSC22D3 TSC22 domain family, member 3
VEGFA vascular endothelial growth factor A
ZCCHC24 zinc finger, CCHC domain containing 24
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CDC25A cell division cycle 25A
CENPU centromere protein U
COCH cochlin
COL2A1 collagen, type II, alpha 1
CRABP2 cellular retinoic acid binding protein 2
CXCL14 chemokine (C-X-C motif) ligand 14
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EMP2 epithelial membrane protein 2
EXOSC4 exosome component 4
FASTKD5 FAST kinase domains 5
FHL1 four and a half LIM domains 1
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GATA3 GATA binding protein 3
HES1 hes family bHLH transcription factor 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IRX5 iroquois homeobox 5
KIF20A kinesin family member 20A
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
MCUR1 mitochondrial calcium uniporter regulator 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
NME4 NME/NM23 nucleoside diphosphate kinase 4
NOLC1 nucleolar and coiled-body phosphoprotein 1
NUSAP1 nucleolar and spindle associated protein 1
OAT ornithine aminotransferase
PEG10 paternally expressed 10
PLK1 polo-like kinase 1
RAD51C RAD51 paralog C
RBMS1 RNA binding motif, single stranded interacting protein 1
RFX5 regulatory factor X, 5 (influences HLA class II expression)
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPL39L ribosomal protein L39-like
RRM2 ribonucleotide reductase M2
RUNX3 runt-related transcription factor 3
S100A7 S100 calcium binding protein A7
SQLE squalene epoxidase
STK26 serine/threonine protein kinase 26
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TACC3 transforming, acidic coiled-coil containing protein 3
TEX10 testis expressed 10
TM4SF1 transmembrane 4 L six family member 1
TSPAN13 tetraspanin 13
TUBB6 tubulin, beta 6 class V
TUSC3 tumor suppressor candidate 3
TXNDC9 thioredoxin domain containing 9