BRD-A47816767_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

153 genes differentially expressed following the BRD-A47816767_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADM adrenomedullin
AK4 adenylate kinase 4
ALDOC aldolase C, fructose-bisphosphate
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ATF3 activating transcription factor 3
BHLHE40 basic helix-loop-helix family, member e40
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
CCL20 chemokine (C-C motif) ligand 20
CD36 CD36 molecule (thrombospondin receptor)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHIC2 cysteine-rich hydrophobic domain 2
CKB creatine kinase, brain
CRYAB crystallin, alpha B
CTH cystathionine gamma-lyase
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DUSP1 dual specificity phosphatase 1
EGR1 early growth response 1
ENO2 enolase 2 (gamma, neuronal)
ENO3 enolase 3 (beta, muscle)
FABP4 fatty acid binding protein 4, adipocyte
FCGBP Fc fragment of IgG binding protein
FOS FBJ murine osteosarcoma viral oncogene homolog
G0S2 G0/G1 switch 2
GADD45B growth arrest and DNA-damage-inducible, beta
GARS glycyl-tRNA synthetase
GCH1 GTP cyclohydrolase 1
GLRX glutaredoxin (thioltransferase)
GPI glucose-6-phosphate isomerase
GRB10 growth factor receptor-bound protein 10
HAL histidine ammonia-lyase
HBB hemoglobin, beta
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HILPDA hypoxia inducible lipid droplet-associated
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IER2 immediate early response 2
IGFBP3 insulin-like growth factor binding protein 3
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGLJ3 immunoglobulin lambda joining 3
INSIG2 insulin induced gene 2
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
JUP junction plakoglobin
KDM3A lysine (K)-specific demethylase 3A
KLF10 Kruppel-like factor 10
KRT1 keratin 1, type II
LGALS8 lectin, galactoside-binding, soluble, 8
LOX lysyl oxidase
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MB myoglobin
MEF2A myocyte enhancer factor 2A
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MT1X metallothionein 1X
NDRG1 N-myc downstream regulated 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEFL neurofilament, light polypeptide
NGRN neugrin, neurite outgrowth associated
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUPL1 nucleoporin like 1
OPTN optineurin
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PCSK6 proprotein convertase subtilisin/kexin type 6
PDGFA platelet-derived growth factor alpha polypeptide
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PFKP phosphofructokinase, platelet
PGK1 phosphoglycerate kinase 1
PKM pyruvate kinase, muscle
PLAGL1 pleiomorphic adenoma gene-like 1
PLIN2 perilipin 2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNMA2 paraneoplastic Ma antigen 2
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTX3 pentraxin 3, long
RALGDS ral guanine nucleotide dissociation stimulator
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RIOK3 RIO kinase 3
RNMT RNA (guanine-7-) methyltransferase
S100A7 S100 calcium binding protein A7
S100P S100 calcium binding protein P
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SFN stratifin
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SSFA2 sperm specific antigen 2
STC2 stanniocalcin 2
TFF3 trefoil factor 3 (intestinal)
TMEM45A transmembrane protein 45A
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNIP1 TNFAIP3 interacting protein 1
TSPAN13 tetraspanin 13
TSPAN7 tetraspanin 7
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
XBP1 X-box binding protein 1
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
AIM1 absent in melanoma 1
ANPEP alanyl (membrane) aminopeptidase
AURKA aurora kinase A
CADPS2 Ca++-dependent secretion activator 2
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCNA2 cyclin A2
CCNF cyclin F
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CENPA centromere protein A
COL1A2 collagen, type I, alpha 2
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FCHO1 FCH domain only 1
FZD2 frizzled class receptor 2
GPNMB glycoprotein (transmembrane) nmb
KANK1 KN motif and ankyrin repeat domains 1
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT7 keratin 7, type II
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
MEIS2 Meis homeobox 2
MMP7 matrix metallopeptidase 7
NDP Norrie disease (pseudoglioma)
NRP1 neuropilin 1
PDZRN3 PDZ domain containing ring finger 3
PNMAL1 paraneoplastic Ma antigen family-like 1
PSRC1 proline/serine-rich coiled-coil 1
RBM47 RNA binding motif protein 47
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SPON1 spondin 1, extracellular matrix protein
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM9SF3 transmembrane 9 superfamily member 3
TOP2A topoisomerase (DNA) II alpha 170kDa
WNT5A wingless-type MMTV integration site family, member 5A
ZFP36L2 ZFP36 ring finger protein-like 2