BRD-A46747628_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

183 genes differentially expressed following the BRD-A46747628_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AEBP1 AE binding protein 1
AKAP8L A kinase (PRKA) anchor protein 8-like
AKAP9 A kinase (PRKA) anchor protein 9
ARHGAP29 Rho GTPase activating protein 29
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATF3 activating transcription factor 3
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BTG2 BTG family, member 2
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CCNL1 cyclin L1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
COL11A1 collagen, type XI, alpha 1
CTGF connective tissue growth factor
CXCL9 chemokine (C-X-C motif) ligand 9
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLC1 DLC1 Rho GTPase activating protein
DUSP1 dual specificity phosphatase 1
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EIF1AX eukaryotic translation initiation factor 1A, X-linked
EIF4A1 eukaryotic translation initiation factor 4A1
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
FHL1 four and a half LIM domains 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GBP1 guanylate binding protein 1, interferon-inducible
GSTM3 glutathione S-transferase mu 3 (brain)
HBEGF heparin-binding EGF-like growth factor
IER2 immediate early response 2
IGFBP5 insulin-like growth factor binding protein 5
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KDM5B lysine (K)-specific demethylase 5B
KDM6B lysine (K)-specific demethylase 6B
KIAA0226L KIAA0226-like
KLF2 Kruppel-like factor 2
KLF6 Kruppel-like factor 6
KLF7 Kruppel-like factor 7 (ubiquitous)
LAMP5 lysosomal-associated membrane protein family, member 5
LRRC15 leucine rich repeat containing 15
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN1A1 mannosidase, alpha, class 1A, member 1
MCL1 myeloid cell leukemia 1
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MMP9 matrix metallopeptidase 9
MPO myeloperoxidase
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MXRA5 matrix-remodelling associated 5
NDRG1 N-myc downstream regulated 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPIPB3 nuclear pore complex interacting protein family, member B3
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NUPL1 nucleoporin like 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCP4 Purkinje cell protein 4
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTBP2 polypyrimidine tract binding protein 2
RABGGTB Rab geranylgeranyltransferase, beta subunit
RGS13 regulator of G-protein signaling 13
RGS16 regulator of G-protein signaling 16
RGS2 regulator of G-protein signaling 2
RLF rearranged L-myc fusion
RPL10 ribosomal protein L10
SAMD4A sterile alpha motif domain containing 4A
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SMAD3 SMAD family member 3
SPAG9 sperm associated antigen 9
SRRM2 serine/arginine repetitive matrix 2
SRSF10 serine/arginine-rich splicing factor 10
SULF1 sulfatase 1
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
THBS1 thrombospondin 1
THY1 Thy-1 cell surface antigen
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TSC22D2 TSC22 domain family, member 2
TUFT1 tuftelin 1
UFM1 ubiquitin-fold modifier 1
VEGFA vascular endothelial growth factor A
XIST X inactive specific transcript (non-protein coding)
ZBED2 zinc finger, BED-type containing 2
ZNF331 zinc finger protein 331
ZNF430 zinc finger protein 430
ZNF586 zinc finger protein 586
ZNF91 zinc finger protein 91
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ADGRG2 adhesion G protein-coupled receptor G2
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANKRD10 ankyrin repeat domain 10
ANXA4 annexin A4
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa
ATMIN ATM interactor
ATP5H ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d
BIN1 bridging integrator 1
C1GALT1C1 C1GALT1-specific chaperone 1
C6ORF62 chromosome 6 open reading frame 62
CADPS2 Ca++-dependent secretion activator 2
CBR1 carbonyl reductase 1
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCNF cyclin F
CENPA centromere protein A
CLCN3 chloride channel, voltage-sensitive 3
COL6A1 collagen, type VI, alpha 1
CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant
CXCL5 chemokine (C-X-C motif) ligand 5
DCLK1 doublecortin-like kinase 1
DDIT4 DNA-damage-inducible transcript 4
DUSP4 dual specificity phosphatase 4
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FANCF Fanconi anemia, complementation group F
G6PD glucose-6-phosphate dehydrogenase
GAS2 growth arrest-specific 2
GDF15 growth differentiation factor 15
GLRX glutaredoxin (thioltransferase)
H2AFX H2A histone family, member X
HMGA2 high mobility group AT-hook 2
HOXA10 homeobox A10
HOXA5 homeobox A5
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IFNGR1 interferon gamma receptor 1
INPP1 inositol polyphosphate-1-phosphatase
JADE2 jade family PHD finger 2
KCTD12 potassium channel tetramerization domain containing 12
KEAP1 kelch-like ECH-associated protein 1
LCMT2 leucine carboxyl methyltransferase 2
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIMCH1 LIM and calponin homology domains 1
MAGED1 melanoma antigen family D1
MCAM melanoma cell adhesion molecule
NNMT nicotinamide N-methyltransferase
NRN1 neuritin 1
NUP62 nucleoporin 62kDa
PIP prolactin-induced protein
PIR pirin (iron-binding nuclear protein)
PLK1 polo-like kinase 1
PMP22 peripheral myelin protein 22
PPARG peroxisome proliferator-activated receptor gamma
PRPF4 pre-mRNA processing factor 4
PSCA prostate stem cell antigen
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RPS4Y1 ribosomal protein S4, Y-linked 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SPTSSA serine palmitoyltransferase, small subunit A
SRPX sushi-repeat containing protein, X-linked
TALDO1 transaldolase 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TM4SF1 transmembrane 4 L six family member 1
TMEM2 transmembrane protein 2
TMX4 thioredoxin-related transmembrane protein 4
TRAPPC4 trafficking protein particle complex 4
TRIP6 thyroid hormone receptor interactor 6
TSPAN8 tetraspanin 8
TUBB tubulin, beta class I
TUBG1 tubulin, gamma 1
TXNDC9 thioredoxin domain containing 9
VCAN versican
WNT5A wingless-type MMTV integration site family, member 5A