BRD-A45498368_WYE-125132_PC3_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

197 genes differentially expressed following the BRD-A45498368_WYE-125132_PC3_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ADAM28 ADAM metallopeptidase domain 28
ADGRG6 adhesion G protein-coupled receptor G6
ANXA3 annexin A3
ANXA4 annexin A4
AREG amphiregulin
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
ATP9A ATPase, class II, type 9A
BHLHE41 basic helix-loop-helix family, member e41
BTBD3 BTB (POZ) domain containing 3
C10ORF10 chromosome 10 open reading frame 10
C6ORF48 chromosome 6 open reading frame 48
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD59 CD59 molecule, complement regulatory protein
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CIRBP cold inducible RNA binding protein
CTSA cathepsin A
CTSD cathepsin D
DDIT3 DNA-damage-inducible transcript 3
DHRS3 dehydrogenase/reductase (SDR family) member 3
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP4 dual specificity phosphatase 4
EFNA1 ephrin-A1
EGFR epidermal growth factor receptor
EMP1 epithelial membrane protein 1
EPCAM epithelial cell adhesion molecule
ERBB2 erb-b2 receptor tyrosine kinase 2
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP4 fatty acid binding protein 4, adipocyte
GADD45B growth arrest and DNA-damage-inducible, beta
GALC galactosylceramidase
GLTSCR2 glioma tumor suppressor candidate region gene 2
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GPNMB glycoprotein (transmembrane) nmb
HACD1 3-hydroxyacyl-CoA dehydratase 1
HBP1 HMG-box transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HMGA2 high mobility group AT-hook 2
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPG2 heparan sulfate proteoglycan 2
IFI27 interferon, alpha-inducible protein 27
IGFBP7 insulin-like growth factor binding protein 7
IRF9 interferon regulatory factor 9
IRS2 insulin receptor substrate 2
JUP junction plakoglobin
KLF5 Kruppel-like factor 5 (intestinal)
KRT18 keratin 18, type I
KRT19 keratin 19, type I
LAMA3 laminin, alpha 3
LETMD1 LETM1 domain containing 1
LGALS4 lectin, galactoside-binding, soluble, 4
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MFAP5 microfibrillar associated protein 5
MFGE8 milk fat globule-EGF factor 8 protein
MVP major vault protein
MXRA7 matrix-remodelling associated 7
MYL9 myosin, light chain 9, regulatory
N4BP2L2 NEDD4 binding protein 2-like 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NET1 neuroepithelial cell transforming 1
NOV nephroblastoma overexpressed
NT5E 5'-nucleotidase, ecto (CD73)
OPTN optineurin
PAN2 PAN2 poly(A) specific ribonuclease subunit
PILRB paired immunoglobin-like type 2 receptor beta
PLCB4 phospholipase C, beta 4
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PRSS23 protease, serine, 23
PTCH1 patched 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBKS ribokinase
RGS5 regulator of G-protein signaling 5
RIOK3 RIO kinase 3
RPL36 ribosomal protein L36
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP4 secreted frizzled-related protein 4
SGK1 serum/glucocorticoid regulated kinase 1
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLC38A2 solute carrier family 38, member 2
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SQSTM1 sequestosome 1
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
TFF1 trefoil factor 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMP3 TIMP metallopeptidase inhibitor 3
TM4SF1 transmembrane 4 L six family member 1
TPM2 tropomyosin 2 (beta)
TPP1 tripeptidyl peptidase I
TRAK1 trafficking protein, kinesin binding 1
TXNIP thioredoxin interacting protein
VAT1 vesicle amine transport 1
VCL vinculin
VEGFC vascular endothelial growth factor C
ZNF185 zinc finger protein 185 (LIM domain)
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
AK4 adenylate kinase 4
ATAD2 ATPase family, AAA domain containing 2
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
C20ORF24 chromosome 20 open reading frame 24
CALML3 calmodulin-like 3
CCDC109B coiled-coil domain containing 109B
CCNE2 cyclin E2
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDC6 cell division cycle 6
CDC7 cell division cycle 7
CENPU centromere protein U
CHN1 chimerin 1
CSTA cystatin A (stefin A)
CYB5A cytochrome b5 type A (microsomal)
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DDIT4 DNA-damage-inducible transcript 4
DPT dermatopontin
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EGLN3 egl-9 family hypoxia-inducible factor 3
EMP2 epithelial membrane protein 2
ENO1 enolase 1, (alpha)
FADS1 fatty acid desaturase 1
FANCI Fanconi anemia, complementation group I
FASN fatty acid synthase
FEN1 flap structure-specific endonuclease 1
GBP1 guanylate binding protein 1, interferon-inducible
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPI glucose-6-phosphate isomerase
H2AFZ H2A histone family, member Z
HAT1 histone acetyltransferase 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA14 heat shock 70kDa protein 14
ICMT isoprenylcysteine carboxyl methyltransferase
IGFBP5 insulin-like growth factor binding protein 5
IL13RA2 interleukin 13 receptor, alpha 2
INSIG1 insulin induced gene 1
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NEFL neurofilament, light polypeptide
NRGN neurogranin (protein kinase C substrate, RC3)
OLFM1 olfactomedin 1
PGK1 phosphoglycerate kinase 1
PHGDH phosphoglycerate dehydrogenase
PI3 peptidase inhibitor 3, skin-derived
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
PTPRD protein tyrosine phosphatase, receptor type, D
RAD51 RAD51 recombinase
RAD54B RAD54 homolog B (S. cerevisiae)
RFC2 replication factor C (activator 1) 2, 40kDa
RRM2 ribonucleotide reductase M2
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
S100A9 S100 calcium binding protein A9
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDC2 syndecan 2
SESN1 sestrin 1
SFN stratifin
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SNAP25 synaptosomal-associated protein, 25kDa
SNRPA1 small nuclear ribonucleoprotein polypeptide A'
SPC25 SPC25, NDC80 kinetochore complex component
SPINK5 serine peptidase inhibitor, Kazal type 5
STRA13 stimulated by retinoic acid 13
SUB1 SUB1 homolog (S. cerevisiae)
TFDP1 transcription factor Dp-1
TK1 thymidine kinase 1, soluble
TMPO thymopoietin
TRIP13 thyroid hormone receptor interactor 13
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)