BRD-A45498368_WYE-125132_PC3_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

248 genes differentially expressed following the BRD-A45498368_WYE-125132_PC3_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ADAM28 ADAM metallopeptidase domain 28
AHNAK2 AHNAK nucleoprotein 2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
AMIGO2 adhesion molecule with Ig-like domain 2
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2
ARHGAP29 Rho GTPase activating protein 29
ATHL1 ATH1, acid trehalase-like 1 (yeast)
BANK1 B-cell scaffold protein with ankyrin repeats 1
BHLHE41 basic helix-loop-helix family, member e41
C10ORF10 chromosome 10 open reading frame 10
C6ORF48 chromosome 6 open reading frame 48
CAV2 caveolin 2
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CD46 CD46 molecule, complement regulatory protein
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CDK7 cyclin-dependent kinase 7
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CELF2 CUGBP, Elav-like family member 2
CEP57 centrosomal protein 57kDa
CEP68 centrosomal protein 68kDa
CHMP4A charged multivesicular body protein 4A
CHN2 chimerin 2
CIRBP cold inducible RNA binding protein
CLIC5 chloride intracellular channel 5
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
CRIP1 cysteine-rich protein 1 (intestinal)
CTGF connective tissue growth factor
CTSH cathepsin H
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DOCK9 dedicator of cytokinesis 9
DSG2 desmoglein 2
DUSP4 dual specificity phosphatase 4
EGFR epidermal growth factor receptor
EMP1 epithelial membrane protein 1
EPCAM epithelial cell adhesion molecule
F2RL1 coagulation factor II (thrombin) receptor-like 1
FLRT2 fibronectin leucine rich transmembrane protein 2
FN1 fibronectin 1
FOLR1 folate receptor 1 (adult)
FOXO3 forkhead box O3
GADD45B growth arrest and DNA-damage-inducible, beta
GCC2 GRIP and coiled-coil domain containing 2
GOLGA8B golgin A8 family, member B
GPX3 glutathione peroxidase 3
GPX4 glutathione peroxidase 4
GSDMB gasdermin B
HBP1 HMG-box transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HIST3H2A histone cluster 3, H2a
HMGA2 high mobility group AT-hook 2
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
IDS iduronate 2-sulfatase
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IGFBP7 insulin-like growth factor binding protein 7
IRS2 insulin receptor substrate 2
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KLHL24 kelch-like family member 24
KLHL9 kelch-like family member 9
KRT18 keratin 18, type I
KRT7 keratin 7, type II
KRT8 keratin 8, type II
LAMC2 laminin, gamma 2
LEPR leptin receptor
LEPROT leptin receptor overlapping transcript
LETMD1 LETM1 domain containing 1
LGALS3 lectin, galactoside-binding, soluble, 3
LIMCH1 LIM and calponin homology domains 1
LOC100505650 uncharacterized LOC100505650
LXN latexin
MAL mal, T-cell differentiation protein
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial
MET MET proto-oncogene, receptor tyrosine kinase
MFAP5 microfibrillar associated protein 5
MGLL monoglyceride lipase
MTUS1 microtubule associated tumor suppressor 1
MVP major vault protein
N4BP2L2 NEDD4 binding protein 2-like 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NMRK1 nicotinamide riboside kinase 1
NR2C1 nuclear receptor subfamily 2, group C, member 1
NT5E 5'-nucleotidase, ecto (CD73)
NUPR1 nuclear protein, transcriptional regulator, 1
OSBPL1A oxysterol binding protein-like 1A
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PAN2 PAN2 poly(A) specific ribonuclease subunit
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
PERP PERP, TP53 apoptosis effector
PGAP3 post-GPI attachment to proteins 3
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PKD1P1 polycystic kidney disease 1 (autosomal dominant) pseudogene 1
PLA2G16 phospholipase A2, group XVI
PLCB4 phospholipase C, beta 4
PLS3 plastin 3
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PPOX protoporphyrinogen oxidase
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PROM1 prominin 1
PRSS23 protease, serine, 23
PRUNE2 prune homolog 2 (Drosophila)
PTEN phosphatase and tensin homolog
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPRM protein tyrosine phosphatase, receptor type, M
PXDC1 PX domain containing 1
QPCT glutaminyl-peptide cyclotransferase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBKS ribokinase
RND3 Rho family GTPase 3
RPL31 ribosomal protein L31
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RRAGC Ras-related GTP binding C
RSRP1 arginine/serine-rich protein 1
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC38A2 solute carrier family 38, member 2
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SPATA7 spermatogenesis associated 7
SQSTM1 sequestosome 1
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STX7 syntaxin 7
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TBX3 T-box 3
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TM4SF1 transmembrane 4 L six family member 1
TPP1 tripeptidyl peptidase I
TSPAN1 tetraspanin 1
TSPAN31 tetraspanin 31
USP34 ubiquitin specific peptidase 34
VAT1 vesicle amine transport 1
ZBED2 zinc finger, BED-type containing 2
ZDHHC11 zinc finger, DHHC-type containing 11
ZNF586 zinc finger protein 586
ZNF83 zinc finger protein 83
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
AK4 adenylate kinase 4
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
AURKB aurora kinase B
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CCNA2 cyclin A2
CCNE2 cyclin E2
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CENPU centromere protein U
COL5A1 collagen, type V, alpha 1
CXCL8 chemokine (C-X-C motif) ligand 8
DBF4 DBF4 zinc finger
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DDIT4 DNA-damage-inducible transcript 4
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EBP emopamil binding protein (sterol isomerase)
EFHD1 EF-hand domain family, member D1
EGLN3 egl-9 family hypoxia-inducible factor 3
EMP2 epithelial membrane protein 2
EXO1 exonuclease 1
FADS1 fatty acid desaturase 1
FASN fatty acid synthase
FEN1 flap structure-specific endonuclease 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GSTM3 glutathione S-transferase mu 3 (brain)
HAT1 histone acetyltransferase 1
HILPDA hypoxia inducible lipid droplet-associated
HIST1H4C histone cluster 1, H4c
HSPA14 heat shock 70kDa protein 14
ICMT isoprenylcysteine carboxyl methyltransferase
INSIG1 insulin induced gene 1
JMJD6 jumonji domain containing 6
LMNB1 lamin B1
LMNB2 lamin B2
LTF lactotransferrin
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NCAPH non-SMC condensin I complex, subunit H
NREP neuronal regeneration related protein
NRGN neurogranin (protein kinase C substrate, RC3)
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PBK PDZ binding kinase
PGK1 phosphoglycerate kinase 1
PHGDH phosphoglycerate dehydrogenase
PI3 peptidase inhibitor 3, skin-derived
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLAT plasminogen activator, tissue
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PRKCA protein kinase C, alpha
PSRC1 proline/serine-rich coiled-coil 1
PTN pleiotrophin
RAD54B RAD54 homolog B (S. cerevisiae)
RCAN1 regulator of calcineurin 1
RFC3 replication factor C (activator 1) 3, 38kDa
RRM2 ribonucleotide reductase M2
S100A7 S100 calcium binding protein A7
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCUBE2 signal peptide, CUB domain, EGF-like 2
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SMC2 structural maintenance of chromosomes 2
SPC25 SPC25, NDC80 kinetochore complex component
STC1 stanniocalcin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TFDP1 transcription factor Dp-1
TIAM1 T-cell lymphoma invasion and metastasis 1
TIMELESS timeless circadian clock
TK1 thymidine kinase 1, soluble
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM97 transmembrane protein 97
TMPO thymopoietin
TNC tenascin C
TOP2A topoisomerase (DNA) II alpha 170kDa
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TUBG1 tubulin, gamma 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VRK1 vaccinia related kinase 1
ZWINT ZW10 interacting kinetochore protein