BRD-A45498368_WYE-125132_PC3_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

152 genes differentially expressed following the BRD-A45498368_WYE-125132_PC3_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAM28 ADAM metallopeptidase domain 28
ADGRG6 adhesion G protein-coupled receptor G6
AGR2 anterior gradient 2
AKR1A1 aldo-keto reductase family 1, member A1 (aldehyde reductase)
ALCAM activated leukocyte cell adhesion molecule
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ATP5G2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
ATP9A ATPase, class II, type 9A
BASP1 brain abundant, membrane attached signal protein 1
BHLHE41 basic helix-loop-helix family, member e41
C6ORF48 chromosome 6 open reading frame 48
CCND1 cyclin D1
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CLIC5 chloride intracellular channel 5
CNPY2 canopy FGF signaling regulator 2
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CRIP1 cysteine-rich protein 1 (intestinal)
CST1 cystatin SN
CTGF connective tissue growth factor
CYR61 cysteine-rich, angiogenic inducer, 61
DALRD3 DALR anticodon binding domain containing 3
DSP desmoplakin
DUSP4 dual specificity phosphatase 4
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNA1 ephrin-A1
EIF4B eukaryotic translation initiation factor 4B
ERGIC3 ERGIC and golgi 3
F2RL1 coagulation factor II (thrombin) receptor-like 1
FN1 fibronectin 1
FOLR1 folate receptor 1 (adult)
FXR1 fragile X mental retardation, autosomal homolog 1
GADD45B growth arrest and DNA-damage-inducible, beta
GLTSCR2 glioma tumor suppressor candidate region gene 2
GRB7 growth factor receptor-bound protein 7
GSDMB gasdermin B
GSN gelsolin
H2AFY H2A histone family, member Y
HMGA2 high mobility group AT-hook 2
IGBP1 immunoglobulin (CD79A) binding protein 1
IGFBP7 insulin-like growth factor binding protein 7
IRF6 interferon regulatory factor 6
IRS2 insulin receptor substrate 2
ITGA6 integrin, alpha 6
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KRT18 keratin 18, type I
KRT19 keratin 19, type I
KRT7 keratin 7, type II
LAMC2 laminin, gamma 2
LASP1 LIM and SH3 protein 1
LEPR leptin receptor
LETMD1 LETM1 domain containing 1
LPAR6 lysophosphatidic acid receptor 6
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP7 microtubule-associated protein 7
MECOM MDS1 and EVI1 complex locus
NET1 neuroepithelial cell transforming 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
OSBPL1A oxysterol binding protein-like 1A
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PAN2 PAN2 poly(A) specific ribonuclease subunit
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PGAP3 post-GPI attachment to proteins 3
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PLCB4 phospholipase C, beta 4
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PROM1 prominin 1
PRSS23 protease, serine, 23
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBKS ribokinase
RND3 Rho family GTPase 3
RPL31 ribosomal protein L31
RPS11 ribosomal protein S11
RSRP1 arginine/serine-rich protein 1
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SMAD3 SMAD family member 3
SORBS2 sorbin and SH3 domain containing 2
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
TFF1 trefoil factor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TIMP3 TIMP metallopeptidase inhibitor 3
TM4SF1 transmembrane 4 L six family member 1
TPCN1 two pore segment channel 1
TPP1 tripeptidyl peptidase I
TSPAN1 tetraspanin 1
TSPAN13 tetraspanin 13
TXNIP thioredoxin interacting protein

decreased expression

Symbol Name
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CA12 carbonic anhydrase XII
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDC7 cell division cycle 7
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CORO1A coronin, actin binding protein, 1A
DBF4 DBF4 zinc finger
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DDIT4 DNA-damage-inducible transcript 4
ELOVL6 ELOVL fatty acid elongase 6
EMP2 epithelial membrane protein 2
FADS1 fatty acid desaturase 1
FAM162A family with sequence similarity 162, member A
FEN1 flap structure-specific endonuclease 1
FGFR4 fibroblast growth factor receptor 4
GARS glycyl-tRNA synthetase
GFOD1 glucose-fructose oxidoreductase domain containing 1
GPI glucose-6-phosphate isomerase
GSTM3 glutathione S-transferase mu 3 (brain)
GYG1 glycogenin 1
HAL histidine ammonia-lyase
HILPDA hypoxia inducible lipid droplet-associated
HK2 hexokinase 2
HSPA14 heat shock 70kDa protein 14
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
INSIG1 insulin induced gene 1
LTB lymphotoxin beta (TNF superfamily, member 3)
LTF lactotransferrin
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
NAMPT nicotinamide phosphoribosyltransferase
NOTCH2 notch 2
PAK1IP1 PAK1 interacting protein 1
PI3 peptidase inhibitor 3, skin-derived
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRKCA protein kinase C, alpha
PSPH phosphoserine phosphatase
RAD51C RAD51 paralog C
REEP1 receptor accessory protein 1
RRM2 ribonucleotide reductase M2
S100A7 S100 calcium binding protein A7
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SESN1 sestrin 1
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFDP1 transcription factor Dp-1
TFRC transferrin receptor
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM45A transmembrane protein 45A
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)