BRD-A45498368_WYE-125132_MDAMB231_3_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

121 genes differentially expressed following the BRD-A45498368_WYE-125132_MDAMB231_3_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AHNAK2 AHNAK nucleoprotein 2
APOD apolipoprotein D
ARID5B AT rich interactive domain 5B (MRF1-like)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BASP1 brain abundant, membrane attached signal protein 1
BHLHE40 basic helix-loop-helix family, member e40
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C10ORF10 chromosome 10 open reading frame 10
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCL20 chemokine (C-C motif) ligand 20
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
COL5A2 collagen, type V, alpha 2
CSNK1E casein kinase 1, epsilon
CTSK cathepsin K
DDIT4 DNA-damage-inducible transcript 4
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42
DUSP22 dual specificity phosphatase 22
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
EAPP E2F-associated phosphoprotein
EPS8L1 EPS8-like 1
FOXO3 forkhead box O3
GADD45B growth arrest and DNA-damage-inducible, beta
GDF15 growth differentiation factor 15
GPX1 glutathione peroxidase 1
HBP1 HMG-box transcription factor 1
HMOX1 heme oxygenase 1
IGF1R insulin-like growth factor 1 receptor
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KDM3A lysine (K)-specific demethylase 3A
KIAA1033 KIAA1033
KIF5C kinesin family member 5C
KLF6 Kruppel-like factor 6
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCAM melanoma cell adhesion molecule
MDK midkine (neurite growth-promoting factor 2)
MGLL monoglyceride lipase
MLPH melanophilin
NAMPT nicotinamide phosphoribosyltransferase
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFIB nuclear factor I/B
NFIL3 nuclear factor, interleukin 3 regulated
NPC1 Niemann-Pick disease, type C1
NUPR1 nuclear protein, transcriptional regulator, 1
PACSIN2 protein kinase C and casein kinase substrate in neurons 2
PSAP prosaposin
RAB31 RAB31, member RAS oncogene family
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
RALGDS ral guanine nucleotide dissociation stimulator
RGS16 regulator of G-protein signaling 16
RHOB ras homolog family member B
SFN stratifin
SIK1 salt-inducible kinase 1
SRPX sushi-repeat containing protein, X-linked
STX1A syntaxin 1A (brain)
TGFBR3 transforming growth factor, beta receptor III
TNNT1 troponin T type 1 (skeletal, slow)
TSPAN8 tetraspanin 8
UGCG UDP-glucose ceramide glucosyltransferase
VNN1 vanin 1
VPS35 vacuolar protein sorting 35 homolog (S. cerevisiae)
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3
ADRB2 adrenoceptor beta 2, surface
BEX1 brain expressed, X-linked 1
BMP4 bone morphogenetic protein 4
CA2 carbonic anhydrase II
CCND2 cyclin D2
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CHGB chromogranin B
CHI3L2 chitinase 3-like 2
CPA3 carboxypeptidase A3 (mast cell)
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
CYTL1 cytokine-like 1
DACH1 dachshund family transcription factor 1
EREG epiregulin
FGFR3 fibroblast growth factor receptor 3
FOSL1 FOS-like antigen 1
GBP1 guanylate binding protein 1, interferon-inducible
GLUL glutamate-ammonia ligase
GRB14 growth factor receptor-bound protein 14
H2AFX H2A histone family, member X
H2BFS H2B histone family, member S (pseudogene)
HBB hemoglobin, beta
HBD hemoglobin, delta
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2BK histone cluster 1, H2bk
HSPA2 heat shock 70kDa protein 2
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGHM immunoglobulin heavy constant mu
KRT13 keratin 13, type I
LOC283683 uncharacterized LOC283683
LTF lactotransferrin
MAP7 microtubule-associated protein 7
NCAM1 neural cell adhesion molecule 1
NR2F6 nuclear receptor subfamily 2, group F, member 6
OBSL1 obscurin-like 1
PCP4 Purkinje cell protein 4
PDZK1 PDZ domain containing 1
PHACTR2 phosphatase and actin regulator 2
RCAN1 regulator of calcineurin 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A8 S100 calcium binding protein A8
SCG2 secretogranin II
SNAP25 synaptosomal-associated protein, 25kDa
SNRPG small nuclear ribonucleoprotein polypeptide G
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TF transferrin
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TPD52L1 tumor protein D52-like 1
VSIG4 V-set and immunoglobulin domain containing 4