BRD-A45498368_WYE-125132_MDAMB231_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

130 genes differentially expressed following the BRD-A45498368_WYE-125132_MDAMB231_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ADIRF adipogenesis regulatory factor
AHNAK2 AHNAK nucleoprotein 2
AMDHD2 amidohydrolase domain containing 2
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA1 annexin A1
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ATHL1 ATH1, acid trehalase-like 1 (yeast)
BHLHE41 basic helix-loop-helix family, member e41
BIK BCL2-interacting killer (apoptosis-inducing)
CCNG2 cyclin G2
CHMP4A charged multivesicular body protein 4A
CHRDL1 chordin-like 1
CST1 cystatin SN
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
DDR1 discoidin domain receptor tyrosine kinase 1
FN1 fibronectin 1
FOXO4 forkhead box O4
GAB2 GRB2-associated binding protein 2
GNPDA1 glucosamine-6-phosphate deaminase 1
GPX3 glutathione peroxidase 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
ICAM1 intercellular adhesion molecule 1
IRS2 insulin receptor substrate 2
ITGAV integrin, alpha V
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KLHL24 kelch-like family member 24
KRT19 keratin 19, type I
LAMP2 lysosomal-associated membrane protein 2
LDLR low density lipoprotein receptor
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGED2 melanoma antigen family D2
MBNL2 muscleblind-like splicing regulator 2
MGST3 microsomal glutathione S-transferase 3
MMD monocyte to macrophage differentiation-associated
MMP1 matrix metallopeptidase 1
MMP7 matrix metallopeptidase 7
MNT MAX network transcriptional repressor
MXI1 MAX interactor 1, dimerization protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
N4BP2L1 NEDD4 binding protein 2-like 1
NEU1 sialidase 1 (lysosomal sialidase)
NPC1 Niemann-Pick disease, type C1
PDGFC platelet derived growth factor C
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLA2G16 phospholipase A2, group XVI
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PROS1 protein S (alpha)
PTX3 pentraxin 3, long
RAP1GAP RAP1 GTPase activating protein
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RNF44 ring finger protein 44
SDCBP syndecan binding protein (syntenin)
SFN stratifin
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SLC16A5 solute carrier family 16 (monocarboxylate transporter), member 5
SQSTM1 sequestosome 1
SULF1 sulfatase 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TBX3 T-box 3
TCEAL4 transcription elongation factor A (SII)-like 4
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TM4SF1 transmembrane 4 L six family member 1
TMEM135 transmembrane protein 135
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNS3 tensin 3
TPP1 tripeptidyl peptidase I
TUBA1A tubulin, alpha 1a
UBQLN2 ubiquilin 2
VAT1 vesicle amine transport 1

decreased expression

Symbol Name
ASF1B anti-silencing function 1B histone chaperone
AUTS2 autism susceptibility candidate 2
BCHE butyrylcholinesterase
CCNA2 cyclin A2
CD320 CD320 molecule
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDC7 cell division cycle 7
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CENPU centromere protein U
CTPS1 CTP synthase 1
DDIT4 DNA-damage-inducible transcript 4
DONSON downstream neighbor of SON
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EGLN3 egl-9 family hypoxia-inducible factor 3
EMX2 empty spiracles homeobox 2
EXO1 exonuclease 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP1 fatty acid binding protein 1, liver
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
FGFR3 fibroblast growth factor receptor 3
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GCH1 GTP cyclohydrolase 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
HAT1 histone acetyltransferase 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
ICMT isoprenylcysteine carboxyl methyltransferase
LTF lactotransferrin
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NR2F2 nuclear receptor subfamily 2, group F, member 2
NUSAP1 nucleolar and spindle associated protein 1
PCNA proliferating cell nuclear antigen
PLAC8 placenta-specific 8
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRKD3 protein kinase D3
PSPH phosphoserine phosphatase
RANBP1 RAN binding protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RRM2 ribonucleotide reductase M2
SPP1 secreted phosphoprotein 1
TK1 thymidine kinase 1, soluble
TMPO thymopoietin
TRIP13 thyroid hormone receptor interactor 13
TUBB4B tubulin, beta 4B class IVb
TUBG1 tubulin, gamma 1
UNG uracil-DNA glycosylase