BRD-A45498368_WYE-125132_MCF7_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

227 genes differentially expressed following the BRD-A45498368_WYE-125132_MCF7_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ACKR3 atypical chemokine receptor 3
ADAM28 ADAM metallopeptidase domain 28
AHR aryl hydrocarbon receptor
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2
ANXA1 annexin A1
ANXA4 annexin A4
ATP9A ATPase, class II, type 9A
BCL6 B-cell CLL/lymphoma 6
C6ORF48 chromosome 6 open reading frame 48
CALCOCO1 calcium binding and coiled-coil domain 1
CAMLG calcium modulating ligand
CAST calpastatin
CCNG1 cyclin G1
CCNG2 cyclin G2
CDK19 cyclin-dependent kinase 19
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CHN1 chimerin 1
CIRBP cold inducible RNA binding protein
CP ceruloplasmin (ferroxidase)
CRISP3 cysteine-rich secretory protein 3
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
DSP desmoplakin
DUSP1 dual specificity phosphatase 1
ECHDC2 enoyl CoA hydratase domain containing 2
EFNA1 ephrin-A1
EIF2D eukaryotic translation initiation factor 2D
EIF3D eukaryotic translation initiation factor 3, subunit D
EIF3E eukaryotic translation initiation factor 3, subunit E
EIF3F eukaryotic translation initiation factor 3, subunit F
EIF3L eukaryotic translation initiation factor 3, subunit L
EIF4B eukaryotic translation initiation factor 4B
ENSA endosulfine alpha
ERBB3 erb-b2 receptor tyrosine kinase 3
EVL Enah/Vasp-like
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXO3 forkhead box O3
FOXO4 forkhead box O4
FXR1 fragile X mental retardation, autosomal homolog 1
GABARAP GABA(A) receptor-associated protein
GATA3 GATA binding protein 3
GBP2 guanylate binding protein 2, interferon-inducible
GCC2 GRIP and coiled-coil domain containing 2
GLTSCR2 glioma tumor suppressor candidate region gene 2
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GPNMB glycoprotein (transmembrane) nmb
GPR137B G protein-coupled receptor 137B
GRN granulin
H1F0 H1 histone family, member 0
HBP1 HMG-box transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2AE histone cluster 1, H2ae
HIST3H2A histone cluster 3, H2a
HNMT histamine N-methyltransferase
HOOK2 hook microtubule-tethering protein 2
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ICA1 islet cell autoantigen 1, 69kDa
IFITM1 interferon induced transmembrane protein 1
IGBP1 immunoglobulin (CD79A) binding protein 1
IGF1R insulin-like growth factor 1 receptor
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
IRF6 interferon regulatory factor 6
KDM3A lysine (K)-specific demethylase 3A
KIZ kizuna centrosomal protein
KLHL24 kelch-like family member 24
LAMP2 lysosomal-associated membrane protein 2
LETMD1 LETM1 domain containing 1
LOC399491
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAL mal, T-cell differentiation protein
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MCL1 myeloid cell leukemia 1
MT1F metallothionein 1F
MT1X metallothionein 1X
MTA1 metastasis associated 1
MTUS1 microtubule associated tumor suppressor 1
MX2 MX dynamin-like GTPase 2
MXI1 MAX interactor 1, dimerization protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
NBR1 neighbor of BRCA1 gene 1
NDRG1 N-myc downstream regulated 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NSA2 NSA2 ribosome biogenesis homolog (S. cerevisiae)
NUPR1 nuclear protein, transcriptional regulator, 1
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
OPTN optineurin
PAN2 PAN2 poly(A) specific ribonuclease subunit
PCBP2 poly(rC) binding protein 2
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
PIGP phosphatidylinositol glycan anchor biosynthesis, class P
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PKD1P1 polycystic kidney disease 1 (autosomal dominant) pseudogene 1
PLCB4 phospholipase C, beta 4
PLK2 polo-like kinase 2
PNRC1 proline-rich nuclear receptor coactivator 1
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PTEN phosphatase and tensin homolog
PTPRO protein tyrosine phosphatase, receptor type, O
RAB40B RAB40B, member RAS oncogene family
RALGDS ral guanine nucleotide dissociation stimulator
RAP1GAP RAP1 GTPase activating protein
RNASET2 ribonuclease T2
RND3 Rho family GTPase 3
RPL31 ribosomal protein L31
RPL36 ribosomal protein L36
RPS11 ribosomal protein S11
RPS14P3 ribosomal protein S14 pseudogene 3
RRAGC Ras-related GTP binding C
SCYL3 SCY1-like 3 (S. cerevisiae)
SEPP1 selenoprotein P, plasma, 1
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SH3YL1 SH3 and SYLF domain containing 1
SLC38A2 solute carrier family 38, member 2
SMAD3 SMAD family member 3
SMYD2 SET and MYND domain containing 2
SOX4 SRY (sex determining region Y)-box 4
SPATA20 spermatogenesis associated 20
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
SYF2 SYF2 pre-mRNA-splicing factor
TBX3 T-box 3
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TMEM30B transmembrane protein 30B
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast)
TPP1 tripeptidyl peptidase I
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
VAT1 vesicle amine transport 1
VCAN versican
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae)
WDR45 WD repeat domain 45
YPEL5 yippee-like 5 (Drosophila)
ZNF277 zinc finger protein 277
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACLY ATP citrate lyase
ACOT7 acyl-CoA thioesterase 7
ADRB2 adrenoceptor beta 2, surface
AK1 adenylate kinase 1
AK4 adenylate kinase 4
ALDOC aldolase C, fructose-bisphosphate
ATAD2 ATPase family, AAA domain containing 2
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
C20ORF24 chromosome 20 open reading frame 24
CCNA2 cyclin A2
CCND3 cyclin D3
CCNE2 cyclin E2
CDC6 cell division cycle 6
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EBP emopamil binding protein (sterol isomerase)
EMP3 epithelial membrane protein 3
ENO1 enolase 1, (alpha)
EREG epiregulin
EZR ezrin
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FASN fatty acid synthase
FEN1 flap structure-specific endonuclease 1
GALE UDP-galactose-4-epimerase
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLIPR1 GLI pathogenesis-related 1
H2AFX H2A histone family, member X
HAT1 histone acetyltransferase 1
HMGA2 high mobility group AT-hook 2
HMGB1 high mobility group box 1
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HOPX HOP homeobox
HSPA14 heat shock 70kDa protein 14
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LPL lipoprotein lipase
LRRC59 leucine rich repeat containing 59
LTF lactotransferrin
MALL mal, T-cell differentiation protein-like
MCM10 minichromosome maintenance complex component 10
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MELK maternal embryonic leucine zipper kinase
MRPL12 mitochondrial ribosomal protein L12
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MSMO1 methylsterol monooxygenase 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NAV3 neuron navigator 3
NES nestin
NPR3 natriuretic peptide receptor 3
ODC1 ornithine decarboxylase 1
P3H2 prolyl 3-hydroxylase 2
PCNA proliferating cell nuclear antigen
PEG10 paternally expressed 10
PGC progastricsin (pepsinogen C)
PHGDH phosphoglycerate dehydrogenase
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRDX1 peroxiredoxin 1
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
PTGDS prostaglandin D2 synthase 21kDa (brain)
RCAN1 regulator of calcineurin 1
RFC2 replication factor C (activator 1) 2, 40kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC52A2 solute carrier family 52 (riboflavin transporter), member 2
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SMCO4 single-pass membrane protein with coiled-coil domains 4
SQLE squalene epoxidase
TCL1A T-cell leukemia/lymphoma 1A
TFRC transferrin receptor
TIMELESS timeless circadian clock
TK1 thymidine kinase 1, soluble
TUBA4A tubulin, alpha 4a
TUBB tubulin, beta class I
TUBB6 tubulin, beta 6 class V
TUBG1 tubulin, gamma 1
ZWINT ZW10 interacting kinetochore protein