BRD-A45498368_WYE-125132_MCF7_24_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

156 genes differentially expressed following the BRD-A45498368_WYE-125132_MCF7_24_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACKR3 atypical chemokine receptor 3
ACTA2 actin, alpha 2, smooth muscle, aorta
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ATHL1 ATH1, acid trehalase-like 1 (yeast)
C14ORF159 chromosome 14 open reading frame 159
C2CD5 C2 calcium-dependent domain containing 5
C6ORF48 chromosome 6 open reading frame 48
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CP ceruloplasmin (ferroxidase)
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
DAPK1 death-associated protein kinase 1
DHRS3 dehydrogenase/reductase (SDR family) member 3
DIAPH2 diaphanous-related formin 2
DKK3 dickkopf WNT signaling pathway inhibitor 3
DSC2 desmocollin 2
EIF3E eukaryotic translation initiation factor 3, subunit E
EIF3F eukaryotic translation initiation factor 3, subunit F
EIF3L eukaryotic translation initiation factor 3, subunit L
EIF4B eukaryotic translation initiation factor 4B
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPCAM epithelial cell adhesion molecule
ERBB3 erb-b2 receptor tyrosine kinase 3
ERBB4 erb-b2 receptor tyrosine kinase 4
EVL Enah/Vasp-like
FBN2 fibrillin 2
FOXO4 forkhead box O4
FXR1 fragile X mental retardation, autosomal homolog 1
GALC galactosylceramidase
GLTSCR2 glioma tumor suppressor candidate region gene 2
GOLGA8A golgin A8 family, member A
GPNMB glycoprotein (transmembrane) nmb
GRN granulin
HBP1 HMG-box transcription factor 1
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-E major histocompatibility complex, class I, E
HOOK2 hook microtubule-tethering protein 2
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IFITM1 interferon induced transmembrane protein 1
IGBP1 immunoglobulin (CD79A) binding protein 1
IGF1R insulin-like growth factor 1 receptor
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
KLHL24 kelch-like family member 24
LETMD1 LETM1 domain containing 1
LPAR6 lysophosphatidic acid receptor 6
LXN latexin
MAP2K5 mitogen-activated protein kinase kinase 5
MMP7 matrix metallopeptidase 7
MTA1 metastasis associated 1
MXI1 MAX interactor 1, dimerization protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEBL nebulette
NPTX2 neuronal pentraxin II
NSA2 NSA2 ribosome biogenesis homolog (S. cerevisiae)
NUPR1 nuclear protein, transcriptional regulator, 1
OLFM4 olfactomedin 4
OXA1L oxidase (cytochrome c) assembly 1-like
PAN2 PAN2 poly(A) specific ribonuclease subunit
PDLIM1 PDZ and LIM domain 1
PLCB4 phospholipase C, beta 4
PNRC1 proline-rich nuclear receptor coactivator 1
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
REG3A regenerating islet-derived 3 alpha
RGS10 regulator of G-protein signaling 10
RPL22 ribosomal protein L22
RPS11 ribosomal protein S11
RPS4Y1 ribosomal protein S4, Y-linked 1
SH3YL1 SH3 and SYLF domain containing 1
SLC16A6 solute carrier family 16, member 6
SLC38A1 solute carrier family 38, member 1
SMAD3 SMAD family member 3
SMYD2 SET and MYND domain containing 2
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPATA20 spermatogenesis associated 20
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3
SRSF5 serine/arginine-rich splicing factor 5
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
TBX3 T-box 3
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPBG trophoblast glycoprotein
TPP1 tripeptidyl peptidase I
VCAN versican
VIM vimentin
WDR45 WD repeat domain 45
YPEL5 yippee-like 5 (Drosophila)
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACLY ATP citrate lyase
ACOT7 acyl-CoA thioesterase 7
BRCA1 breast cancer 1, early onset
BTG3 BTG family, member 3
C20ORF24 chromosome 20 open reading frame 24
CCNE2 cyclin E2
CD320 CD320 molecule
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDK2 cyclin-dependent kinase 2
CYBA cytochrome b-245, alpha polypeptide
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DEF8 differentially expressed in FDCP 8 homolog (mouse)
DHCR7 7-dehydrocholesterol reductase
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EBP emopamil binding protein (sterol isomerase)
EIF1AX eukaryotic translation initiation factor 1A, X-linked
EIF5A eukaryotic translation initiation factor 5A
EMP3 epithelial membrane protein 3
ENDOD1 endonuclease domain containing 1
ENO1 enolase 1, (alpha)
FEN1 flap structure-specific endonuclease 1
G0S2 G0/G1 switch 2
GCH1 GTP cyclohydrolase 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
HAT1 histone acetyltransferase 1
HOPX HOP homeobox
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA8 heat shock 70kDa protein 8
ICMT isoprenylcysteine carboxyl methyltransferase
IER3 immediate early response 3
ISG15 ISG15 ubiquitin-like modifier
LMO4 LIM domain only 4
MALL mal, T-cell differentiation protein-like
MAP2K3 mitogen-activated protein kinase kinase 3
MCM10 minichromosome maintenance complex component 10
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MRPS12 mitochondrial ribosomal protein S12
NQO1 NAD(P)H dehydrogenase, quinone 1
P4HB prolyl 4-hydroxylase, beta polypeptide
PARP2 poly (ADP-ribose) polymerase 2
PCNA proliferating cell nuclear antigen
PGK1 phosphoglycerate kinase 1
PHGDH phosphoglycerate dehydrogenase
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPIF peptidylprolyl isomerase F
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3
RFC2 replication factor C (activator 1) 2, 40kDa
RRM2 ribonucleotide reductase M2
SCAND1 SCAN domain containing 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SQLE squalene epoxidase
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TAGLN2 transgelin 2
TGFB1 transforming growth factor, beta 1
TK1 thymidine kinase 1, soluble
TUBB6 tubulin, beta 6 class V
TUBG1 tubulin, gamma 1
XIST X inactive specific transcript (non-protein coding)