BRD-A45498368_WYE-125132_MCF7_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

118 genes differentially expressed following the BRD-A45498368_WYE-125132_MCF7_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ARHGAP32 Rho GTPase activating protein 32
ATP9A ATPase, class II, type 9A
C2CD5 C2 calcium-dependent domain containing 5
C6ORF48 chromosome 6 open reading frame 48
CAST calpastatin
CCNG2 cyclin G2
CD24 CD24 molecule
CDK5RAP3 CDK5 regulatory subunit associated protein 3
DIAPH2 diaphanous-related formin 2
DKK3 dickkopf WNT signaling pathway inhibitor 3
EIF3F eukaryotic translation initiation factor 3, subunit F
EIF3L eukaryotic translation initiation factor 3, subunit L
EIF4B eukaryotic translation initiation factor 4B
ERBB2 erb-b2 receptor tyrosine kinase 2
EVL Enah/Vasp-like
FBN2 fibrillin 2
FCGBP Fc fragment of IgG binding protein
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FXR1 fragile X mental retardation, autosomal homolog 1
GLTSCR2 glioma tumor suppressor candidate region gene 2
GOLGA8A golgin A8 family, member A
GPR137B G protein-coupled receptor 137B
GRN granulin
HBP1 HMG-box transcription factor 1
HIST3H2A histone cluster 3, H2a
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IGBP1 immunoglobulin (CD79A) binding protein 1
IGF1R insulin-like growth factor 1 receptor
IGFBP7 insulin-like growth factor binding protein 7
KLHL24 kelch-like family member 24
LETMD1 LETM1 domain containing 1
LTA4H leukotriene A4 hydrolase
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAP2K5 mitogen-activated protein kinase kinase 5
MARCKSL1 MARCKS-like 1
MTA1 metastasis associated 1
MXI1 MAX interactor 1, dimerization protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
NSG1 neuron specific gene family member 1
PAN2 PAN2 poly(A) specific ribonuclease subunit
PCBP2 poly(rC) binding protein 2
PDLIM1 PDZ and LIM domain 1
PGLS 6-phosphogluconolactonase
PNRC1 proline-rich nuclear receptor coactivator 1
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PRKCQ protein kinase C, theta
RIN2 Ras and Rab interactor 2
RPL15 ribosomal protein L15
RPS11 ribosomal protein S11
SAT1 spermidine/spermine N1-acetyltransferase 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SMAD3 SMAD family member 3
SPATA20 spermatogenesis associated 20
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
TPP1 tripeptidyl peptidase I
WASL Wiskott-Aldrich syndrome-like
ZHX2 zinc fingers and homeoboxes 2
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACLY ATP citrate lyase
ACOT7 acyl-CoA thioesterase 7
AQP3 aquaporin 3 (Gill blood group)
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATAD2 ATPase family, AAA domain containing 2
BST2 bone marrow stromal cell antigen 2
C3 complement component 3
CALCA calcitonin-related polypeptide alpha
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDKN3 cyclin-dependent kinase inhibitor 3
CKS1B CDC28 protein kinase regulatory subunit 1B
COL3A1 collagen, type III, alpha 1
CPM carboxypeptidase M
CXCL2 chemokine (C-X-C motif) ligand 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DHCR7 7-dehydrocholesterol reductase
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EBP emopamil binding protein (sterol isomerase)
ENO1 enolase 1, (alpha)
EREG epiregulin
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLIPR1 GLI pathogenesis-related 1
HSPA8 heat shock 70kDa protein 8
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
ISG15 ISG15 ubiquitin-like modifier
LRRC59 leucine rich repeat containing 59
LTF lactotransferrin
MALL mal, T-cell differentiation protein-like
MARS methionyl-tRNA synthetase
MCM10 minichromosome maintenance complex component 10
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NME1 NME/NM23 nucleoside diphosphate kinase 1
NPR3 natriuretic peptide receptor 3
ODC1 ornithine decarboxylase 1
PGC progastricsin (pepsinogen C)
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3
RFC3 replication factor C (activator 1) 3, 38kDa
RRM2 ribonucleotide reductase M2
SDC2 syndecan 2
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SQLE squalene epoxidase
STIP1 stress-induced phosphoprotein 1
TAGLN2 transgelin 2
TFRC transferrin receptor
TK1 thymidine kinase 1, soluble
TSPYL5 TSPY-like 5
TUBA4A tubulin, alpha 4a
TUBB6 tubulin, beta 6 class V
TUBG1 tubulin, gamma 1
UBE2S ubiquitin-conjugating enzyme E2S
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)