BRD-A45498368_WYE-125132_MCF10A_3_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

107 genes differentially expressed following the BRD-A45498368_WYE-125132_MCF10A_3_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADIRF adipogenesis regulatory factor
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANXA10 annexin A10
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CBR3 carbonyl reductase 3
CCNG2 cyclin G2
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CHRDL1 chordin-like 1
CIRBP cold inducible RNA binding protein
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLC Charcot-Leyden crystal galectin
CXCL12 chemokine (C-X-C motif) ligand 12
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DSP desmoplakin
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGFR epidermal growth factor receptor
EZR ezrin
FOLR1 folate receptor 1 (adult)
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPX3 glutathione peroxidase 3
HBP1 HMG-box transcription factor 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGB2 high mobility group box 2
HMOX1 heme oxygenase 1
HNMT histamine N-methyltransferase
HOXC6 homeobox C6
IGF1R insulin-like growth factor 1 receptor
IGHM immunoglobulin heavy constant mu
IRS2 insulin receptor substrate 2
KIF14 kinesin family member 14
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLHL21 kelch-like family member 21
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MARCKS myristoylated alanine-rich protein kinase C substrate
MGLL monoglyceride lipase
MT1M metallothionein 1M
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NUPR1 nuclear protein, transcriptional regulator, 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PENK proenkephalin
PROM1 prominin 1
RBP4 retinol binding protein 4, plasma
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
RIOK3 RIO kinase 3
SKAP2 src kinase associated phosphoprotein 2
SLC35F2 solute carrier family 35, member F2
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SNX11 sorting nexin 11
SOD2 superoxide dismutase 2, mitochondrial
STX1A syntaxin 1A (brain)
SYNE2 spectrin repeat containing, nuclear envelope 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR3 transforming growth factor, beta receptor III
TSC22D3 TSC22 domain family, member 3
TUSC3 tumor suppressor candidate 3
TXNIP thioredoxin interacting protein
VNN1 vanin 1

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADO 2-aminoethanethiol (cysteamine) dioxygenase
BAG2 BCL2-associated athanogene 2
CADM1 cell adhesion molecule 1
CCL20 chemokine (C-C motif) ligand 20
CDC25A cell division cycle 25A
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CNN3 calponin 3, acidic
DHRS2 dehydrogenase/reductase (SDR family) member 2
EGR1 early growth response 1
EGR2 early growth response 2
EREG epiregulin
ESR1 estrogen receptor 1
FABP6 fatty acid binding protein 6, ileal
FADS1 fatty acid desaturase 1
FASTKD5 FAST kinase domains 5
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GRIA2 glutamate receptor, ionotropic, AMPA 2
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HBB hemoglobin, beta
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOPX HOP homeobox
HSPA1A heat shock 70kDa protein 1A
IL1B interleukin 1, beta
JMJD6 jumonji domain containing 6
KRT18 keratin 18, type I
LAPTM4B lysosomal protein transmembrane 4 beta
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LRRN3 leucine rich repeat neuronal 3
MAGEA4 melanoma antigen family A4
MAT2A methionine adenosyltransferase II, alpha
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NOP2 NOP2 nucleolar protein
PCP4 Purkinje cell protein 4
PDLIM5 PDZ and LIM domain 5
PHLDA1 pleckstrin homology-like domain, family A, member 1
PRAME preferentially expressed antigen in melanoma
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A8 S100 calcium binding protein A8
SNAP25 synaptosomal-associated protein, 25kDa
SPAG4 sperm associated antigen 4
TARS threonyl-tRNA synthetase
VSNL1 visinin-like 1
WDR3 WD repeat domain 3
WFDC2 WAP four-disulfide core domain 2