BRD-A45498368_WYE-125132_MCF10A_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

108 genes differentially expressed following the BRD-A45498368_WYE-125132_MCF10A_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
AIM1 absent in melanoma 1
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ANXA3 annexin A3
APOD apolipoprotein D
AQP1 aquaporin 1 (Colton blood group)
ARMCX2 armadillo repeat containing, X-linked 2
CCNG2 cyclin G2
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CFH complement factor H
CHIC2 cysteine-rich hydrophobic domain 2
CIRBP cold inducible RNA binding protein
CPE carboxypeptidase E
CREB1 cAMP responsive element binding protein 1
CRYAB crystallin, alpha B
CSRP2 cysteine and glycine-rich protein 2
CTGF connective tissue growth factor
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DSP desmoplakin
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGFR epidermal growth factor receptor
EPHA3 EPH receptor A3
FAM129A family with sequence similarity 129, member A
FBN1 fibrillin 1
FHL1 four and a half LIM domains 1
FN1 fibronectin 1
GLUL glutamate-ammonia ligase
GULP1 GULP, engulfment adaptor PTB domain containing 1
HIST1H4C histone cluster 1, H4c
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
KIAA0355 KIAA0355
KIF14 kinesin family member 14
KLHDC2 kelch domain containing 2
MAPK13 mitogen-activated protein kinase 13
METTL7A methyltransferase like 7A
MME membrane metallo-endopeptidase
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1X metallothionein 1X
NAV2 neuron navigator 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFIB nuclear factor I/B
NOTCH2NL notch 2 N-terminal like
OAT ornithine aminotransferase
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
RGS2 regulator of G-protein signaling 2
RPS4Y1 ribosomal protein S4, Y-linked 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP1 secreted frizzled-related protein 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SOD2 superoxide dismutase 2, mitochondrial
SORBS1 sorbin and SH3 domain containing 1
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SQSTM1 sequestosome 1
SRPX sushi-repeat containing protein, X-linked
SYNE2 spectrin repeat containing, nuclear envelope 2
TCF4 transcription factor 4
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TSC22D3 TSC22 domain family, member 3
TUBA1A tubulin, alpha 1a
TXNIP thioredoxin interacting protein
VCAN versican
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ADM adrenomedullin
AGR2 anterior gradient 2
CCND1 cyclin D1
CD8A CD8a molecule
CDC25A cell division cycle 25A
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CPB1 carboxypeptidase B1 (tissue)
ELANE elastase, neutrophil expressed
FASTKD5 FAST kinase domains 5
GATA6 GATA binding protein 6
GBP1 guanylate binding protein 1, interferon-inducible
GPX2 glutathione peroxidase 2
HBB hemoglobin, beta
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
JMJD6 jumonji domain containing 6
KLK10 kallikrein-related peptidase 10
MEIS1 Meis homeobox 1
MYLK myosin light chain kinase
NPDC1 neural proliferation, differentiation and control, 1
NR2F1 nuclear receptor subfamily 2, group F, member 1
NUP62 nucleoporin 62kDa
PELO pelota homolog (Drosophila)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A8 S100 calcium binding protein A8
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SLPI secretory leukocyte peptidase inhibitor
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SPRR3 small proline-rich protein 3
SQLE squalene epoxidase
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
TFRC transferrin receptor
TM4SF1 transmembrane 4 L six family member 1
WT1 Wilms tumor 1