BRD-A45498368_WYE-125132_LNCAP_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

274 genes differentially expressed following the BRD-A45498368_WYE-125132_LNCAP_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACSL3 acyl-CoA synthetase long-chain family member 3
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMIGO2 adhesion molecule with Ig-like domain 2
ANKRD36B ankyrin repeat domain 36B
ARID5B AT rich interactive domain 5B (MRF1-like)
ATMIN ATM interactor
ATP9A ATPase, class II, type 9A
BCAM basal cell adhesion molecule (Lutheran blood group)
BEX4 brain expressed, X-linked 4
BICD1 bicaudal D homolog 1 (Drosophila)
BPTF bromodomain PHD finger transcription factor
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CD44 CD44 molecule (Indian blood group)
CIRBP cold inducible RNA binding protein
COL9A2 collagen, type IX, alpha 2
COLEC12 collectin sub-family member 12
CPE carboxypeptidase E
CST3 cystatin C
DLG5 discs, large homolog 5 (Drosophila)
DUSP4 dual specificity phosphatase 4
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2
EFNB2 ephrin-B2
EIF4B eukaryotic translation initiation factor 4B
ENOSF1 enolase superfamily member 1
ERBB2 erb-b2 receptor tyrosine kinase 2
F3 coagulation factor III (thromboplastin, tissue factor)
FAM46A family with sequence similarity 46, member A
FXR1 fragile X mental retardation, autosomal homolog 1
GABARAPL1 GABA(A) receptor-associated protein like 1
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GLTSCR2 glioma tumor suppressor candidate region gene 2
GOLGA4 golgin A4
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GOLGA8H golgin A8 family, member H
GOLGB1 golgin B1
GOLM1 golgi membrane protein 1
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
ICA1 islet cell autoantigen 1, 69kDa
IDS iduronate 2-sulfatase
IGF1R insulin-like growth factor 1 receptor
IGFBP3 insulin-like growth factor binding protein 3
INSR insulin receptor
IRS2 insulin receptor substrate 2
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
KDM3A lysine (K)-specific demethylase 3A
KDM5A lysine (K)-specific demethylase 5A
KDM5D lysine (K)-specific demethylase 5D
KIAA1109 KIAA1109
KLK2 kallikrein-related peptidase 2
KLK3 kallikrein-related peptidase 3
LAMB2 laminin, beta 2 (laminin S)
LAMC2 laminin, gamma 2
LDOC1 leucine zipper, down-regulated in cancer 1
LOC100272216 uncharacterized LOC100272216
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGED1 melanoma antigen family D1
MAN2C1 mannosidase, alpha, class 2C, member 1
MAOA monoamine oxidase A
MFSD10 major facilitator superfamily domain containing 10
MZF1 myeloid zinc finger 1
N4BP2L2 NEDD4 binding protein 2-like 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NOTCH2NL notch 2 N-terminal like
OBSL1 obscurin-like 1
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PKD1P1 polycystic kidney disease 1 (autosomal dominant) pseudogene 1
PLEKHA5 pleckstrin homology domain containing, family A member 5
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLXNA1 plexin A1
PNKP polynucleotide kinase 3'-phosphatase
PTN pleiotrophin
PTPRE protein tyrosine phosphatase, receptor type, E
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RGL2 ral guanine nucleotide dissociation stimulator-like 2
RNASET2 ribonuclease T2
RPL31 ribosomal protein L31
RSRP1 arginine/serine-rich protein 1
RUFY3 RUN and FYVE domain containing 3
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG5 secretogranin V
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SH3BGRL SH3 domain binding glutamate-rich protein like
SIDT2 SID1 transmembrane family, member 2
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SORBS3 sorbin and SH3 domain containing 3
SPARCL1 SPARC-like 1 (hevin)
SPATA20 spermatogenesis associated 20
SPDEF SAM pointed domain containing ETS transcription factor
SYT17 synaptotagmin XVII
TBX3 T-box 3
TFF3 trefoil factor 3 (intestinal)
TFPI2 tissue factor pathway inhibitor 2
TIMP3 TIMP metallopeptidase inhibitor 3
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast)
TPP1 tripeptidyl peptidase I
TRA2A transformer 2 alpha homolog (Drosophila)
TTC17 tetratricopeptide repeat domain 17
TUSC3 tumor suppressor candidate 3
TXNIP thioredoxin interacting protein
USP34 ubiquitin specific peptidase 34
WSB1 WD repeat and SOCS box containing 1
YBX3 Y box binding protein 3
ZMIZ1 zinc finger, MIZ-type containing 1
ZNF264 zinc finger protein 264
ZNF587 zinc finger protein 587
ZNF83 zinc finger protein 83
ZNF91 zinc finger protein 91
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDOB aldolase B, fructose-bisphosphate
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ASF1A anti-silencing function 1A histone chaperone
ASF1B anti-silencing function 1B histone chaperone
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATAD2 ATPase family, AAA domain containing 2
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCNA2 cyclin A2
CCNE2 cyclin E2
CD27 CD27 molecule
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPM centromere protein M
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CHEK2 checkpoint kinase 2
CKS1B CDC28 protein kinase regulatory subunit 1B
CSTA cystatin A (stefin A)
CXCL5 chemokine (C-X-C motif) ligand 5
CYCS cytochrome c, somatic
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DBF4 DBF4 zinc finger
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DDIT4 DNA-damage-inducible transcript 4
DHFR dihydrofolate reductase
DHRS2 dehydrogenase/reductase (SDR family) member 2
DIO1 deiodinase, iodothyronine, type I
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EBP emopamil binding protein (sterol isomerase)
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ELOVL6 ELOVL fatty acid elongase 6
ENO1 enolase 1, (alpha)
EXO1 exonuclease 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
FOXM1 forkhead box M1
GARS glycyl-tRNA synthetase
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GGCT gamma-glutamylcyclotransferase
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GINS4 GINS complex subunit 4 (Sld5 homolog)
GPX2 glutathione peroxidase 2
GTSE1 G-2 and S-phase expressed 1
H2AFX H2A histone family, member X
HILPDA hypoxia inducible lipid droplet-associated
HJURP Holliday junction recognition protein
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
IL7R interleukin 7 receptor
INSIG1 insulin induced gene 1
JCHAIN joining chain of multimeric IgA and IgM
KIAA0101 KIAA0101
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF4A kinesin family member 4A
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LMNB2 lamin B2
LMO4 LIM domain only 4
LRIF1 ligand dependent nuclear receptor interacting factor 1
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MICB MHC class I polypeptide-related sequence B
MTERF3 mitochondrial transcription termination factor 3
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NDC80 NDC80 kinetochore complex component
NEK2 NIMA-related kinase 2
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1
NUSAP1 nucleolar and spindle associated protein 1
OIP5 Opa interacting protein 5
OLFM1 olfactomedin 1
ORC6 origin recognition complex, subunit 6
PBK PDZ binding kinase
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PCNA proliferating cell nuclear antigen
PHGDH phosphoglycerate dehydrogenase
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNP purine nucleoside phosphorylase
POLA2 polymerase (DNA directed), alpha 2, accessory subunit
PRC1 protein regulator of cytokinesis 1
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PSAT1 phosphoserine aminotransferase 1
PSPH phosphoserine phosphatase
RAD51 RAD51 recombinase
RAD54B RAD54 homolog B (S. cerevisiae)
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RNASEH2A ribonuclease H2, subunit A
RPL39L ribosomal protein L39-like
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SDC1 syndecan 1
SHCBP1 SHC SH2-domain binding protein 1
SHMT1 serine hydroxymethyltransferase 1 (soluble)
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SMC1A structural maintenance of chromosomes 1A
SPAG5 sperm associated antigen 5
SPC25 SPC25, NDC80 kinetochore complex component
STC2 stanniocalcin 2
STMN1 stathmin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TAGLN2 transgelin 2
TFRC transferrin receptor
TIMELESS timeless circadian clock
TK1 thymidine kinase 1, soluble
TMEM194A transmembrane protein 194A
TMPO thymopoietin
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
VRK1 vaccinia related kinase 1
WARS tryptophanyl-tRNA synthetase
ZWILCH zwilch kinetochore protein
ZWINT ZW10 interacting kinetochore protein