BRD-A45498368_WYE-125132_HT29_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

196 genes differentially expressed following the BRD-A45498368_WYE-125132_HT29_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
AHR aryl hydrocarbon receptor
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA3 annexin A3
ANXA4 annexin A4
ARHGAP29 Rho GTPase activating protein 29
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
ASPH aspartate beta-hydroxylase
ATP9A ATPase, class II, type 9A
BEX1 brain expressed, X-linked 1
BEX4 brain expressed, X-linked 4
BIN1 bridging integrator 1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
CRIP1 cysteine-rich protein 1 (intestinal)
CTSA cathepsin A
CTSB cathepsin B
CTSL cathepsin L
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DCLK1 doublecortin-like kinase 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DRAM1 DNA-damage regulated autophagy modulator 1
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EFNA1 ephrin-A1
FABP4 fatty acid binding protein 4, adipocyte
FAM50A family with sequence similarity 50, member A
FNBP1L formin binding protein 1-like
FOLR1 folate receptor 1 (adult)
FOS FBJ murine osteosarcoma viral oncogene homolog
FTH1 ferritin, heavy polypeptide 1
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11
GSN gelsolin
IDS iduronate 2-sulfatase
IGBP1 immunoglobulin (CD79A) binding protein 1
IRS2 insulin receptor substrate 2
ITGB5 integrin, beta 5
KLHL24 kelch-like family member 24
LAMA3 laminin, alpha 3
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LXN latexin
MACROD1 MACRO domain containing 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MBNL2 muscleblind-like splicing regulator 2
METRN meteorin, glial cell differentiation regulator
MGLL monoglyceride lipase
MTMR11 myotubularin related protein 11
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MVP major vault protein
MXI1 MAX interactor 1, dimerization protein
MYRF myelin regulatory factor
NPC1 Niemann-Pick disease, type C1
NPDC1 neural proliferation, differentiation and control, 1
OPTN optineurin
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHYH phytanoyl-CoA 2-hydroxylase
PLA2G16 phospholipase A2, group XVI
PLK2 polo-like kinase 2
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPAP2C phosphatidic acid phosphatase type 2C
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
RAB4A RAB4A, member RAS oncogene family
RAP1GAP RAP1 GTPase activating protein
RPS27L ribosomal protein S27-like
RPS4Y1 ribosomal protein S4, Y-linked 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SECISBP2L SECIS binding protein 2-like
SH3YL1 SH3 and SYLF domain containing 1
SMAD3 SMAD family member 3
SORBS3 sorbin and SH3 domain containing 3
SOX9 SRY (sex determining region Y)-box 9
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SQSTM1 sequestosome 1
SRPX sushi-repeat containing protein, X-linked
SYT1 synaptotagmin I
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TESC tescalcin
TM4SF1 transmembrane 4 L six family member 1
TM4SF4 transmembrane 4 L six family member 4
TPPP3 tubulin polymerization-promoting protein family member 3
TSC22D1 TSC22 domain family, member 1
TSPAN1 tetraspanin 1

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
AMD1 adenosylmethionine decarboxylase 1
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ASF1A anti-silencing function 1A histone chaperone
ASNS asparagine synthetase (glutamine-hydrolyzing)
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CASP1 caspase 1, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CCNA2 cyclin A2
CCND2 cyclin D2
CD320 CD320 molecule
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CEP55 centrosomal protein 55kDa
CHEK2 checkpoint kinase 2
CKS1B CDC28 protein kinase regulatory subunit 1B
COL3A1 collagen, type III, alpha 1
CPE carboxypeptidase E
CSTA cystatin A (stefin A)
CYCS cytochrome c, somatic
DBF4 DBF4 zinc finger
DHCR7 7-dehydrocholesterol reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EBP emopamil binding protein (sterol isomerase)
EDNRB endothelin receptor type B
FABP1 fatty acid binding protein 1, liver
FOXM1 forkhead box M1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
H2AFX H2A histone family, member X
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGB2 high mobility group box 2
HMGB3 high mobility group box 3
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
IDO1 indoleamine 2,3-dioxygenase 1
IGFBP5 insulin-like growth factor binding protein 5
IGHM immunoglobulin heavy constant mu
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
JCHAIN joining chain of multimeric IgA and IgM
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT6A keratin 6A, type II
LBR lamin B receptor
LEF1 lymphoid enhancer-binding factor 1
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LMNB2 lamin B2
MAL mal, T-cell differentiation protein
MARS methionyl-tRNA synthetase
MCM10 minichromosome maintenance complex component 10
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NDC80 NDC80 kinetochore complex component
NEK2 NIMA-related kinase 2
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
OIP5 Opa interacting protein 5
OLFM4 olfactomedin 4
PBK PDZ binding kinase
PCDH9 protocadherin 9
PCP4 Purkinje cell protein 4
PEG10 paternally expressed 10
PGAM1 phosphoglycerate mutase 1 (brain)
PHGDH phosphoglycerate dehydrogenase
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PRC1 protein regulator of cytokinesis 1
PTTG1 pituitary tumor-transforming 1
RAD23B RAD23 homolog B (S. cerevisiae)
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RRM2 ribonucleotide reductase M2
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SPC25 SPC25, NDC80 kinetochore complex component
SUB1 SUB1 homolog (S. cerevisiae)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TDO2 tryptophan 2,3-dioxygenase
TK1 thymidine kinase 1, soluble
TMEM194A transmembrane protein 194A
TMEM97 transmembrane protein 97
TMPO thymopoietin
TOR3A torsin family 3, member A
TRBC1 T cell receptor beta constant 1
TRIP13 thyroid hormone receptor interactor 13
UBE2S ubiquitin-conjugating enzyme E2S
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
VRK1 vaccinia related kinase 1
XIST X inactive specific transcript (non-protein coding)
ZW10 zw10 kinetochore protein