BRD-A45498368_WYE-125132_HS578T_3_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

106 genes differentially expressed following the BRD-A45498368_WYE-125132_HS578T_3_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ARL4C ADP-ribosylation factor-like 4C
ATF4 activating transcription factor 4
C6ORF48 chromosome 6 open reading frame 48
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CTSE cathepsin E
DAPK1 death-associated protein kinase 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EIF5 eukaryotic translation initiation factor 5
FAM13A family with sequence similarity 13, member A
FGFR4 fibroblast growth factor receptor 4
FNDC3B fibronectin type III domain containing 3B
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
HIST1H2AC histone cluster 1, H2ac
HLA-E major histocompatibility complex, class I, E
HMOX1 heme oxygenase 1
IER3 immediate early response 3
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IKZF1 IKAROS family zinc finger 1 (Ikaros)
JUN jun proto-oncogene
KLF6 Kruppel-like factor 6
KLHL21 kelch-like family member 21
MYC v-myc avian myelocytomatosis viral oncogene homolog
NPC1 Niemann-Pick disease, type C1
ORC1 origin recognition complex, subunit 1
PAN2 PAN2 poly(A) specific ribonuclease subunit
PDGFC platelet derived growth factor C
PF4 platelet factor 4
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNRC1 proline-rich nuclear receptor coactivator 1
RIOK3 RIO kinase 3
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SOX4 SRY (sex determining region Y)-box 4
SPRED2 sprouty-related, EVH1 domain containing 2
STX1A syntaxin 1A (brain)
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFF3 trefoil factor 3 (intestinal)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TRAK2 trafficking protein, kinesin binding 2
TXNIP thioredoxin interacting protein

decreased expression

Symbol Name
ACAT1 acetyl-CoA acetyltransferase 1
ACTN1 actinin, alpha 1
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
ARHGAP29 Rho GTPase activating protein 29
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
C3 complement component 3
CADM1 cell adhesion molecule 1
CDC25A cell division cycle 25A
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
DDIT4 DNA-damage-inducible transcript 4
DPYSL3 dihydropyrimidinase-like 3
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FUCA1 fucosidase, alpha-L- 1, tissue
GCLM glutamate-cysteine ligase, modifier subunit
GPNMB glycoprotein (transmembrane) nmb
HSPA1A heat shock 70kDa protein 1A
IFI27 interferon, alpha-inducible protein 27
IL1RN interleukin 1 receptor antagonist
INSIG1 insulin induced gene 1
KRT13 keratin 13, type I
KRT19 keratin 19, type I
KRT4 keratin 4, type II
LBR lamin B receptor
LCN2 lipocalin 2
LY6D lymphocyte antigen 6 complex, locus D
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MGP matrix Gla protein
MMP9 matrix metallopeptidase 9
MRPL40 mitochondrial ribosomal protein L40
MXRA7 matrix-remodelling associated 7
PCCB propionyl CoA carboxylase, beta polypeptide
PCP4 Purkinje cell protein 4
PEBP1 phosphatidylethanolamine binding protein 1
PI3 peptidase inhibitor 3, skin-derived
PPIC peptidylprolyl isomerase C (cyclophilin C)
PRKCH protein kinase C, eta
RANBP1 RAN binding protein 1
RGCC regulator of cell cycle
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A10 S100 calcium binding protein A10
S100A11 S100 calcium binding protein A11
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SELL selectin L
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SPP1 secreted phosphoprotein 1
SPRR1A small proline-rich protein 1A
SPRR2B small proline-rich protein 2B
SPRR3 small proline-rich protein 3
SQLE squalene epoxidase
TACSTD2 tumor-associated calcium signal transducer 2
UPK1B uroplakin 1B