BRD-A45498368_WYE-125132_HS578T_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

97 genes differentially expressed following the BRD-A45498368_WYE-125132_HS578T_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
AMOTL2 angiomotin like 2
ARID5B AT rich interactive domain 5B (MRF1-like)
ARL4C ADP-ribosylation factor-like 4C
ATF3 activating transcription factor 3
BTG1 B-cell translocation gene 1, anti-proliferative
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CCNL1 cyclin L1
CD52 CD52 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CREB1 cAMP responsive element binding protein 1
CRYAB crystallin, alpha B
CTGF connective tissue growth factor
CTSK cathepsin K
CXCL14 chemokine (C-X-C motif) ligand 14
DARS aspartyl-tRNA synthetase
DSP desmoplakin
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45A growth arrest and DNA-damage-inducible, alpha
GDF15 growth differentiation factor 15
GOLGA8A golgin A8 family, member A
GPC3 glypican 3
GRB14 growth factor receptor-bound protein 14
GULP1 GULP, engulfment adaptor PTB domain containing 1
IER3 immediate early response 3
IGHM immunoglobulin heavy constant mu
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KRT14 keratin 14, type I
LPAR6 lysophosphatidic acid receptor 6
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MGLL monoglyceride lipase
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAV2 neuron navigator 2
NFIL3 nuclear factor, interleukin 3 regulated
NR4A2 nuclear receptor subfamily 4, group A, member 2
OSBPL10 oxysterol binding protein-like 10
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RBP4 retinol binding protein 4, plasma
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
STK17A serine/threonine kinase 17a
STX1A syntaxin 1A (brain)
SULF1 sulfatase 1
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TIA1 TIA1 cytotoxic granule-associated RNA binding protein
TNC tenascin C
TOX3 TOX high mobility group box family member 3
TPD52 tumor protein D52
TUBB2A tubulin, beta 2A class IIa
WSB1 WD repeat and SOCS box containing 1

decreased expression

Symbol Name
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ARF3 ADP-ribosylation factor 3
ARMT1 acidic residue methyltransferase 1
ASS1 argininosuccinate synthase 1
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BIK BCL2-interacting killer (apoptosis-inducing)
C3 complement component 3
CCND3 cyclin D3
CDC25A cell division cycle 25A
CLU clusterin
CSTA cystatin A (stefin A)
CTSH cathepsin H
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
FABP5 fatty acid binding protein 5 (psoriasis-associated)
GCLM glutamate-cysteine ligase, modifier subunit
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
JMJD6 jumonji domain containing 6
LAMA3 laminin, alpha 3
LMO2 LIM domain only 2 (rhombotin-like 1)
MAT2A methionine adenosyltransferase II, alpha
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1X metallothionein 1X
MYB v-myb avian myeloblastosis viral oncogene homolog
PEX11A peroxisomal biogenesis factor 11 alpha
PI3 peptidase inhibitor 3, skin-derived
PMEL premelanosome protein
PODXL podocalyxin-like
PTGDS prostaglandin D2 synthase 21kDa (brain)
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SQLE squalene epoxidase
TOB1 transducer of ERBB2, 1
VAV3 vav 3 guanine nucleotide exchange factor
WT1 Wilms tumor 1