BRD-A45498368_WYE-125132_HS578T_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

279 genes differentially expressed following the BRD-A45498368_WYE-125132_HS578T_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ADCK3 aarF domain containing kinase 3
AGTPBP1 ATP/GTP binding protein 1
AHNAK2 AHNAK nucleoprotein 2
AKAP9 A kinase (PRKA) anchor protein 9
AMDHD2 amidohydrolase domain containing 2
ANGPTL2 angiopoietin-like 2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANKRD36B ankyrin repeat domain 36B
ANXA4 annexin A4
ARMCX1 armadillo repeat containing, X-linked 1
ASPN asporin
ATG12 autophagy related 12
AZGP1 alpha-2-glycoprotein 1, zinc-binding
C6ORF48 chromosome 6 open reading frame 48
CAMLG calcium modulating ligand
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CDC25B cell division cycle 25B
CDK19 cyclin-dependent kinase 19
CEP68 centrosomal protein 68kDa
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHRDL1 chordin-like 1
CIRBP cold inducible RNA binding protein
CLEC2B C-type lectin domain family 2, member B
COCH cochlin
COL11A1 collagen, type XI, alpha 1
COL8A2 collagen, type VIII, alpha 2
COLEC11 collectin sub-family member 11
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
CRYAB crystallin, alpha B
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTGF connective tissue growth factor
CTSK cathepsin K
DCLK1 doublecortin-like kinase 1
DICER1 dicer 1, ribonuclease type III
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila)
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLK1 delta-like 1 homolog (Drosophila)
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DUSP3 dual specificity phosphatase 3
EIF4A2 eukaryotic translation initiation factor 4A2
EMP1 epithelial membrane protein 1
F13A1 coagulation factor XIII, A1 polypeptide
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM8A1 family with sequence similarity 8, member A1
FGF13 fibroblast growth factor 13
FNBP1 formin binding protein 1
FNTA farnesyltransferase, CAAX box, alpha
FXR1 fragile X mental retardation, autosomal homolog 1
FXYD2 FXYD domain containing ion transport regulator 2
FZD7 frizzled class receptor 7
GAB2 GRB2-associated binding protein 2
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GCC2 GRIP and coiled-coil domain containing 2
GLG1 golgi glycoprotein 1
GPRASP1 G protein-coupled receptor associated sorting protein 1
GPRC5B G protein-coupled receptor, class C, group 5, member B
GRB14 growth factor receptor-bound protein 14
GSE1 Gse1 coiled-coil protein
GSN gelsolin
GSPT2 G1 to S phase transition 2
HDAC6 histone deacetylase 6
HEPH hephaestin
HIST3H2A histone cluster 3, H2a
HMGA2 high mobility group AT-hook 2
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
HSPA2 heat shock 70kDa protein 2
HSPB7 heat shock 27kDa protein family, member 7 (cardiovascular)
IDS iduronate 2-sulfatase
IGBP1 immunoglobulin (CD79A) binding protein 1
IRS2 insulin receptor substrate 2
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
JADE2 jade family PHD finger 2
JUP junction plakoglobin
KIAA1033 KIAA1033
KIF5C kinesin family member 5C
KLHL21 kelch-like family member 21
KLHL24 kelch-like family member 24
LEPR leptin receptor
LGALS3 lectin, galactoside-binding, soluble, 3
LGALS4 lectin, galactoside-binding, soluble, 4
LINC00341 long intergenic non-protein coding RNA 341
LINC00342 long intergenic non-protein coding RNA 342
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGED1 melanoma antigen family D1
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial
MFGE8 milk fat globule-EGF factor 8 protein
MTMR11 myotubularin related protein 11
MYO6 myosin VI
N4BP2L1 NEDD4 binding protein 2-like 1
NAP1L1 nucleosome assembly protein 1-like 1
NCOA3 nuclear receptor coactivator 3
NINL ninein-like
NONO non-POU domain containing, octamer-binding
NPC1 Niemann-Pick disease, type C1
NPDC1 neural proliferation, differentiation and control, 1
NPTX2 neuronal pentraxin II
NT5E 5'-nucleotidase, ecto (CD73)
OPTN optineurin
PDE4B phosphodiesterase 4B, cAMP-specific
PHYH phytanoyl-CoA 2-hydroxylase
PILRB paired immunoglobin-like type 2 receptor beta
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
PROM1 prominin 1
PRR15L proline rich 15-like
PTGIS prostaglandin I2 (prostacyclin) synthase
RAP2A RAP2A, member of RAS oncogene family
RGS17 regulator of G-protein signaling 17
RRAGD Ras-related GTP binding D
SAT1 spermidine/spermine N1-acetyltransferase 1
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLC38A1 solute carrier family 38, member 1
SOD2 superoxide dismutase 2, mitochondrial
SOX9 SRY (sex determining region Y)-box 9
ST18 suppression of tumorigenicity 18, zinc finger
STX7 syntaxin 7
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
SYNM synemin, intermediate filament protein
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
THBS4 thrombospondin 4
TM4SF1 transmembrane 4 L six family member 1
TNPO1 transportin 1
TPR translocated promoter region, nuclear basket protein
TRAK2 trafficking protein, kinesin binding 2
TRIB2 tribbles pseudokinase 2
TSPAN4 tetraspanin 4
TTC3 tetratricopeptide repeat domain 3
UBE2B ubiquitin-conjugating enzyme E2B
VAT1 vesicle amine transport 1
VCAN versican
VNN1 vanin 1
WDR13 WD repeat domain 13
WWP1 WW domain containing E3 ubiquitin protein ligase 1
ZDHHC11 zinc finger, DHHC-type containing 11
ZNF277 zinc finger protein 277
ZNF292 zinc finger protein 292

decreased expression

Symbol Name
AARS alanyl-tRNA synthetase
ACAT2 acetyl-CoA acetyltransferase 2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALG8 ALG8, alpha-1,3-glucosyltransferase
APOC1 apolipoprotein C-I
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPH aspartate beta-hydroxylase
ATF6 activating transcription factor 6
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
C20ORF24 chromosome 20 open reading frame 24
CBS cystathionine-beta-synthase
CCND3 cyclin D3
CCNE2 cyclin E2
CD320 CD320 molecule
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDK2 cyclin-dependent kinase 2
CENPU centromere protein U
CFH complement factor H
CKAP4 cytoskeleton-associated protein 4
CKLF chemokine-like factor
COL1A2 collagen, type I, alpha 2
CSRP2 cysteine and glycine-rich protein 2
CTPS1 CTP synthase 1
CTSC cathepsin C
CTSZ cathepsin Z
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL8 chemokine (C-X-C motif) ligand 8
CYB5A cytochrome b5 type A (microsomal)
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUT deoxyuridine triphosphatase
EGLN3 egl-9 family hypoxia-inducible factor 3
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EMP2 epithelial membrane protein 2
EMP3 epithelial membrane protein 3
EPB41L3 erythrocyte membrane protein band 4.1-like 3
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ESR1 estrogen receptor 1
FADS1 fatty acid desaturase 1
FEN1 flap structure-specific endonuclease 1
FGFBP1 fibroblast growth factor binding protein 1
FKBP14 FK506 binding protein 14, 22 kDa
FOLR1 folate receptor 1 (adult)
GALE UDP-galactose-4-epimerase
GBP1 guanylate binding protein 1, interferon-inducible
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GINS3 GINS complex subunit 3 (Psf3 homolog)
GLIPR1 GLI pathogenesis-related 1
GSTM3 glutathione S-transferase mu 3 (brain)
GSTP1 glutathione S-transferase pi 1
HEG1 heart development protein with EGF-like domains 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPB11 heat shock protein family B (small), member 11
ICMT isoprenylcysteine carboxyl methyltransferase
IDI1 isopentenyl-diphosphate delta isomerase 1
IGKC immunoglobulin kappa constant
LMNB1 lamin B1
LRRC17 leucine rich repeat containing 17
LRRC59 leucine rich repeat containing 59
LYZ lysozyme
MANF mesencephalic astrocyte-derived neurotrophic factor
MARS methionyl-tRNA synthetase
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM5 minichromosome maintenance complex component 5
METTL7A methyltransferase like 7A
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MSMO1 methylsterol monooxygenase 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NME1 NME/NM23 nucleoside diphosphate kinase 1
NME4 NME/NM23 nucleoside diphosphate kinase 4
PCNA proliferating cell nuclear antigen
PDIA4 protein disulfide isomerase family A, member 4
PEX11A peroxisomal biogenesis factor 11 alpha
PFN2 profilin 2
PGAM1 phosphoglycerate mutase 1 (brain)
PGD phosphogluconate dehydrogenase
PGK1 phosphoglycerate kinase 1
PHGDH phosphoglycerate dehydrogenase
PIR pirin (iron-binding nuclear protein)
PLAC8 placenta-specific 8
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PON2 paraoxonase 2
PSAT1 phosphoserine aminotransferase 1
PYCR1 pyrroline-5-carboxylate reductase 1
RGS1 regulator of G-protein signaling 1
RPN2 ribophorin II
RRM2 ribonucleotide reductase M2
S100A11 S100 calcium binding protein A11
SCARB1 scavenger receptor class B, member 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB2A1 secretoglobin, family 2A, member 1
SDF2L1 stromal cell-derived factor 2-like 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SFTPB surfactant protein B
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SORD sorbitol dehydrogenase
SQLE squalene epoxidase
SRGN serglycin
STRA13 stimulated by retinoic acid 13
TARS threonyl-tRNA synthetase
TIMELESS timeless circadian clock
TK1 thymidine kinase 1, soluble
TMEM14A transmembrane protein 14A
TMEM176B transmembrane protein 176B
TMEM97 transmembrane protein 97
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
WARS tryptophanyl-tRNA synthetase
WNT5A wingless-type MMTV integration site family, member 5A
YARS tyrosyl-tRNA synthetase
ZWINT ZW10 interacting kinetochore protein