BRD-A45498368_WYE-125132_HME1_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

111 genes differentially expressed following the BRD-A45498368_WYE-125132_HME1_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ACTA2 actin, alpha 2, smooth muscle, aorta
ACTG2 actin, gamma 2, smooth muscle, enteric
AKAP13 A kinase (PRKA) anchor protein 13
APOD apolipoprotein D
ARID5B AT rich interactive domain 5B (MRF1-like)
ATF3 activating transcription factor 3
BIRC2 baculoviral IAP repeat containing 2
BTG1 B-cell translocation gene 1, anti-proliferative
C8ORF4 chromosome 8 open reading frame 4
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CHIC2 cysteine-rich hydrophobic domain 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COL5A2 collagen, type V, alpha 2
CSRP1 cysteine and glycine-rich protein 1
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FAS Fas cell surface death receptor
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45B growth arrest and DNA-damage-inducible, beta
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GPRC5B G protein-coupled receptor, class C, group 5, member B
HBP1 HMG-box transcription factor 1
HOMER1 homer scaffolding protein 1
HOXC6 homeobox C6
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IGF1R insulin-like growth factor 1 receptor
IQCK IQ motif containing K
IRS2 insulin receptor substrate 2
ITM2A integral membrane protein 2A
KIAA1033 KIAA1033
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLF5 Kruppel-like factor 5 (intestinal)
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
KLHL21 kelch-like family member 21
KRT17 keratin 17, type I
LITAF lipopolysaccharide-induced TNF factor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MEF2C myocyte enhancer factor 2C
MYH11 myosin, heavy chain 11, smooth muscle
NPC1 Niemann-Pick disease, type C1
NRIP1 nuclear receptor interacting protein 1
NT5E 5'-nucleotidase, ecto (CD73)
OLFML2A olfactomedin-like 2A
OSBPL1A oxysterol binding protein-like 1A
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PLAUR plasminogen activator, urokinase receptor
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POSTN periostin, osteoblast specific factor
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RGCC regulator of cell cycle
SAT1 spermidine/spermine N1-acetyltransferase 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SLC16A6 solute carrier family 16, member 6
STX1A syntaxin 1A (brain)
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
SYNE2 spectrin repeat containing, nuclear envelope 2
TBX2 T-box 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TSC22D3 TSC22 domain family, member 3
UBXN7 UBX domain protein 7
UGCG UDP-glucose ceramide glucosyltransferase
VNN1 vanin 1

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AHSG alpha-2-HS-glycoprotein
AKR1C3 aldo-keto reductase family 1, member C3
ALB albumin
APOA2 apolipoprotein A-II
CCNE2 cyclin E2
CCR2 chemokine (C-C motif) receptor 2
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDC25A cell division cycle 25A
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CFB complement factor B
DACH1 dachshund family transcription factor 1
DDIT4 DNA-damage-inducible transcript 4
EIF5A eukaryotic translation initiation factor 5A
FGG fibrinogen gamma chain
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GNAS GNAS complex locus
GPI glucose-6-phosphate isomerase
GSTA1 glutathione S-transferase alpha 1
IFRD2 interferon-related developmental regulator 2
KRT13 keratin 13, type I
LAPTM4B lysosomal protein transmembrane 4 beta
LAPTM5 lysosomal protein transmembrane 5
LEF1 lymphoid enhancer-binding factor 1
LYZ lysozyme
MAP1B microtubule-associated protein 1B
MXRA7 matrix-remodelling associated 7
PDZK1IP1 PDZK1 interacting protein 1
PGAM1 phosphoglycerate mutase 1 (brain)
PLIN2 perilipin 2
PRSS2 protease, serine, 2 (trypsin 2)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A7 S100 calcium binding protein A7
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFN stratifin
SPTSSA serine palmitoyltransferase, small subunit A
TF transferrin
XIST X inactive specific transcript (non-protein coding)
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon