BRD-A45498368_WYE-125132_HME1_3_h_0.12_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

89 genes differentially expressed following the BRD-A45498368_WYE-125132_HME1_3_h_0.12_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
AHNAK AHNAK nucleoprotein
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANXA1 annexin A1
APOD apolipoprotein D
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
ARHGAP29 Rho GTPase activating protein 29
ARID5B AT rich interactive domain 5B (MRF1-like)
ATF3 activating transcription factor 3
CADM1 cell adhesion molecule 1
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CHIC2 cysteine-rich hydrophobic domain 2
CTGF connective tissue growth factor
CXCL12 chemokine (C-X-C motif) ligand 12
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCN decorin
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLK1 delta-like 1 homolog (Drosophila)
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
EPAS1 endothelial PAS domain protein 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GMDS GDP-mannose 4,6-dehydratase
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GPM6B glycoprotein M6B
GPX3 glutathione peroxidase 3
HBP1 HMG-box transcription factor 1
HMGA1 high mobility group AT-hook 1
HMGB2 high mobility group box 2
ICAM1 intercellular adhesion molecule 1
IFITM1 interferon induced transmembrane protein 1
IGFBP5 insulin-like growth factor binding protein 5
IL6 interleukin 6
IL6ST interleukin 6 signal transducer
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KLF6 Kruppel-like factor 6
KLHL21 kelch-like family member 21
MET MET proto-oncogene, receptor tyrosine kinase
MMP2 matrix metallopeptidase 2
MYOF myoferlin
NUPR1 nuclear protein, transcriptional regulator, 1
PEG3 paternally expressed 3
PNKP polynucleotide kinase 3'-phosphatase
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
TGIF1 TGFB-induced factor homeobox 1
TM4SF1 transmembrane 4 L six family member 1
TSC22D3 TSC22 domain family, member 3
VCAM1 vascular cell adhesion molecule 1
WIF1 WNT inhibitory factor 1
ZIC1 Zic family member 1

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C3 aldo-keto reductase family 1, member C3
ALB albumin
ALDOB aldolase B, fructose-bisphosphate
CA12 carbonic anhydrase XII
CDC25A cell division cycle 25A
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CSTA cystatin A (stefin A)
CXADR coxsackie virus and adenovirus receptor
DDIT4 DNA-damage-inducible transcript 4
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
ITM2C integral membrane protein 2C
JMJD6 jumonji domain containing 6
KRT13 keratin 13, type I
KRT5 keratin 5, type II
LAPTM4B lysosomal protein transmembrane 4 beta
LY75 lymphocyte antigen 75
MRPS2 mitochondrial ribosomal protein S2
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NOP16 NOP16 nucleolar protein
OLFM4 olfactomedin 4
PI3 peptidase inhibitor 3, skin-derived
PPP1R3C protein phosphatase 1, regulatory subunit 3C
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SPINK5 serine peptidase inhibitor, Kazal type 5
SPRR1A small proline-rich protein 1A
SPRR2B small proline-rich protein 2B
SPTSSA serine palmitoyltransferase, small subunit A
TIGAR TP53 induced glycolysis regulatory phosphatase
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1