BRD-A45498368_WYE-125132_HME1_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

312 genes differentially expressed following the BRD-A45498368_WYE-125132_HME1_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
AHNAK AHNAK nucleoprotein
AMDHD2 amidohydrolase domain containing 2
ANKRD36B ankyrin repeat domain 36B
ANXA4 annexin A4
ATF4 activating transcription factor 4
ATG12 autophagy related 12
BTG1 B-cell translocation gene 1, anti-proliferative
C5AR1 complement component 5a receptor 1
C6ORF48 chromosome 6 open reading frame 48
CAMLG calcium modulating ligand
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CST1 cystatin SN
CTSB cathepsin B
CTSH cathepsin H
CTSK cathepsin K
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
DARS aspartyl-tRNA synthetase
DHRS7 dehydrogenase/reductase (SDR family) member 7
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DUSP4 dual specificity phosphatase 4
EFNA1 ephrin-A1
EGFR epidermal growth factor receptor
EIF3D eukaryotic translation initiation factor 3, subunit D
EIF3E eukaryotic translation initiation factor 3, subunit E
EIF3F eukaryotic translation initiation factor 3, subunit F
EIF3G eukaryotic translation initiation factor 3, subunit G
EIF3H eukaryotic translation initiation factor 3, subunit H
EIF3L eukaryotic translation initiation factor 3, subunit L
EIF4A2 eukaryotic translation initiation factor 4A2
EIF4B eukaryotic translation initiation factor 4B
ETHE1 ethylmalonic encephalopathy 1
F13A1 coagulation factor XIII, A1 polypeptide
FTH1 ferritin, heavy polypeptide 1
FXR1 fragile X mental retardation, autosomal homolog 1
GCC2 GRIP and coiled-coil domain containing 2
GLTSCR2 glioma tumor suppressor candidate region gene 2
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GPATCH8 G patch domain containing 8
GPNMB glycoprotein (transmembrane) nmb
GRN granulin
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBP1 HMG-box transcription factor 1
HIST3H2A histone cluster 3, H2a
HLA-E major histocompatibility complex, class I, E
ICAM1 intercellular adhesion molecule 1
IDS iduronate 2-sulfatase
IFITM1 interferon induced transmembrane protein 1
IGBP1 immunoglobulin (CD79A) binding protein 1
IGF1R insulin-like growth factor 1 receptor
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IGF2R insulin-like growth factor 2 receptor
IGFBP1 insulin-like growth factor binding protein 1
IL1B interleukin 1, beta
IL6 interleukin 6
IRS2 insulin receptor substrate 2
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
LAMA3 laminin, alpha 3
LETMD1 LETM1 domain containing 1
LGALS3 lectin, galactoside-binding, soluble, 3
LIMS1 LIM and senescent cell antigen-like domains 1
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MGLL monoglyceride lipase
MLPH melanophilin
MME membrane metallo-endopeptidase
MMP1 matrix metallopeptidase 1
MMP12 matrix metallopeptidase 12
MTMR11 myotubularin related protein 11
MTSS1 metastasis suppressor 1
MXI1 MAX interactor 1, dimerization protein
MYO1D myosin ID
MYO6 myosin VI
N4BP2L1 NEDD4 binding protein 2-like 1
N4BP2L2 NEDD4 binding protein 2-like 2
NDRG1 N-myc downstream regulated 1
NKTR natural killer cell triggering receptor
NPC1 Niemann-Pick disease, type C1
NPC2 Niemann-Pick disease, type C2
NPIPB3 nuclear pore complex interacting protein family, member B3
NUPR1 nuclear protein, transcriptional regulator, 1
PLBD1 phospholipase B domain containing 1
PLEKHA5 pleckstrin homology domain containing, family A member 5
PNRC1 proline-rich nuclear receptor coactivator 1
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PROM1 prominin 1
PRRC2C proline-rich coiled-coil 2C
PRSS8 protease, serine, 8
PSAP prosaposin
QPCT glutaminyl-peptide cyclotransferase
RAB29 RAB29, member RAS oncogene family
RGS10 regulator of G-protein signaling 10
RIOK3 RIO kinase 3
RNASET2 ribonuclease T2
RNMT RNA (guanine-7-) methyltransferase
RPL22 ribosomal protein L22
RPL36 ribosomal protein L36
RPL4 ribosomal protein L4
RRAGD Ras-related GTP binding D
RSL1D1 ribosomal L1 domain containing 1
RSL24D1 ribosomal L24 domain containing 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERINC1 serine incorporator 1
SLC16A6 solute carrier family 16, member 6
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC35E2B solute carrier family 35, member E2B
SLC35F2 solute carrier family 35, member F2
SOD2 superoxide dismutase 2, mitochondrial
SOX4 SRY (sex determining region Y)-box 4
SPATA20 spermatogenesis associated 20
SPINK1 serine peptidase inhibitor, Kazal type 1
SPON2 spondin 2, extracellular matrix protein
SQSTM1 sequestosome 1
SRRM2 serine/arginine repetitive matrix 2
SSPN sarcospan
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
STX1A syntaxin 1A (brain)
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast)
TPP1 tripeptidyl peptidase I
TSPAN31 tetraspanin 31
VAT1 vesicle amine transport 1
VNN1 vanin 1
VWA8 von Willebrand factor A domain containing 8
WDR45 WD repeat domain 45
WIPI1 WD repeat domain, phosphoinositide interacting 1
WNK1 WNK lysine deficient protein kinase 1
YPEL5 yippee-like 5 (Drosophila)
ZNF277 zinc finger protein 277
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ACSL1 acyl-CoA synthetase long-chain family member 1
ADI1 acireductone dioxygenase 1
AKAP7 A kinase (PRKA) anchor protein 7
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
AQP3 aquaporin 3 (Gill blood group)
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
AURKB aurora kinase B
BARD1 BRCA1 associated RING domain 1
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C3ORF14 chromosome 3 open reading frame 14
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCNE2 cyclin E2
CCNF cyclin F
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDC7 cell division cycle 7
CDCA3 cell division cycle associated 3
CDCA8 cell division cycle associated 8
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
CLU clusterin
CNN3 calponin 3, acidic
COL1A2 collagen, type I, alpha 2
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSRP2 cysteine and glycine-rich protein 2
CYB5A cytochrome b5 type A (microsomal)
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DDIT4 DNA-damage-inducible transcript 4
DEPDC1 DEP domain containing 1
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EBP emopamil binding protein (sterol isomerase)
ELAVL1 ELAV like RNA binding protein 1
ENO1 enolase 1, (alpha)
EXO1 exonuclease 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FANCI Fanconi anemia, complementation group I
FAS Fas cell surface death receptor
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FEN1 flap structure-specific endonuclease 1
FOXM1 forkhead box M1
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1
GCLM glutamate-cysteine ligase, modifier subunit
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GTSE1 G-2 and S-phase expressed 1
H2AFX H2A histone family, member X
H2AFZ H2A histone family, member Z
HAT1 histone acetyltransferase 1
HMGB3 high mobility group box 3
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMMR hyaluronan-mediated motility receptor (RHAMM)
HSPA14 heat shock 70kDa protein 14
HSPB1 heat shock 27kDa protein 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
IGL immunoglobulin lambda locus
INSIG1 insulin induced gene 1
KANK1 KN motif and ankyrin repeat domains 1
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4
KIAA0101 KIAA0101
KIF14 kinesin family member 14
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF4A kinesin family member 4A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT5 keratin 5, type II
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LMNB2 lamin B2
LPL lipoprotein lipase
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
METTL7A methyltransferase like 7A
MKI67 marker of proliferation Ki-67
MSMO1 methylsterol monooxygenase 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NCAPH non-SMC condensin I complex, subunit H
NDC80 NDC80 kinetochore complex component
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NEK2 NIMA-related kinase 2
NET1 neuroepithelial cell transforming 1
NME1 NME/NM23 nucleoside diphosphate kinase 1
NUP107 nucleoporin 107kDa
NUSAP1 nucleolar and spindle associated protein 1
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PDIA4 protein disulfide isomerase family A, member 4
PHGDH phosphoglycerate dehydrogenase
PLAC8 placenta-specific 8
PLK1 polo-like kinase 1
PLK4 polo-like kinase 4
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PLS1 plastin 1
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRC1 protein regulator of cytokinesis 1
PTTG1 pituitary tumor-transforming 1
RACGAP1 Rac GTPase activating protein 1
RAD51C RAD51 paralog C
RANBP1 RAN binding protein 1
RFC3 replication factor C (activator 1) 3, 38kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RHOB ras homolog family member B
RPA3 replication protein A3, 14kDa
RPN2 ribophorin II
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SHCBP1 SHC SH2-domain binding protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SMC2 structural maintenance of chromosomes 2
SMC4 structural maintenance of chromosomes 4
SNRPG small nuclear ribonucleoprotein polypeptide G
SPAG5 sperm associated antigen 5
SPC25 SPC25, NDC80 kinetochore complex component
STMN1 stathmin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TES testin LIM domain protein
TFDP1 transcription factor Dp-1
TIMELESS timeless circadian clock
TK1 thymidine kinase 1, soluble
TMEM47 transmembrane protein 47
TMPO thymopoietin
TMX1 thioredoxin-related transmembrane protein 1
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TUBB4B tubulin, beta 4B class IVb
TWF1 twinfilin actin binding protein 1
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VRK1 vaccinia related kinase 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWINT ZW10 interacting kinetochore protein