BRD-A45498368_WYE-125132_HME1_24_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

231 genes differentially expressed following the BRD-A45498368_WYE-125132_HME1_24_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
AHNAK2 AHNAK nucleoprotein 2
ANXA4 annexin A4
ASMTL acetylserotonin O-methyltransferase-like
ATP9A ATPase, class II, type 9A
BHLHE41 basic helix-loop-helix family, member e41
C6ORF48 chromosome 6 open reading frame 48
CAMLG calcium modulating ligand
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CD200 CD200 molecule
CD44 CD44 molecule (Indian blood group)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CERS6 ceramide synthase 6
CFD complement factor D (adipsin)
CHPT1 choline phosphotransferase 1
CIRBP cold inducible RNA binding protein
CTSB cathepsin B
CTSF cathepsin F
CUTA cutA divalent cation tolerance homolog (E. coli)
DARS aspartyl-tRNA synthetase
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DRAM1 DNA-damage regulated autophagy modulator 1
DSG2 desmoglein 2
DSP desmoplakin
DUSP4 dual specificity phosphatase 4
ECHDC2 enoyl CoA hydratase domain containing 2
EGFR epidermal growth factor receptor
EIF3E eukaryotic translation initiation factor 3, subunit E
EIF3F eukaryotic translation initiation factor 3, subunit F
EIF3G eukaryotic translation initiation factor 3, subunit G
EIF4B eukaryotic translation initiation factor 4B
ETHE1 ethylmalonic encephalopathy 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAR2 fatty acyl CoA reductase 2
FNBP1 formin binding protein 1
FTH1 ferritin, heavy polypeptide 1
FXR1 fragile X mental retardation, autosomal homolog 1
FXYD5 FXYD domain containing ion transport regulator 5
GFOD1 glucose-fructose oxidoreductase domain containing 1
GRN granulin
HBP1 HMG-box transcription factor 1
HDAC9 histone deacetylase 9
HLA-E major histocompatibility complex, class I, E
IDS iduronate 2-sulfatase
IFITM1 interferon induced transmembrane protein 1
IGBP1 immunoglobulin (CD79A) binding protein 1
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IL18 interleukin 18
IL1B interleukin 1, beta
IRF6 interferon regulatory factor 6
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
LAMA3 laminin, alpha 3
LAMC2 laminin, gamma 2
LAMP2 lysosomal-associated membrane protein 2
LETMD1 LETM1 domain containing 1
LGALS3 lectin, galactoside-binding, soluble, 3
LIMS1 LIM and senescent cell antigen-like domains 1
LRRC16A leucine rich repeat containing 16A
LTA4H leukotriene A4 hydrolase
MAB21L1 mab-21-like 1 (C. elegans)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAP1B microtubule-associated protein 1B
MARK4 MAP/microtubule affinity-regulating kinase 4
MFAP5 microfibrillar associated protein 5
MFGE8 milk fat globule-EGF factor 8 protein
MMP7 matrix metallopeptidase 7
MXI1 MAX interactor 1, dimerization protein
MXRA5 matrix-remodelling associated 5
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NDRG1 N-myc downstream regulated 1
NPC1 Niemann-Pick disease, type C1
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NUPR1 nuclear protein, transcriptional regulator, 1
OPTN optineurin
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form)
PAMR1 peptidase domain containing associated with muscle regeneration 1
PLBD1 phospholipase B domain containing 1
PLCB4 phospholipase C, beta 4
PLEKHA5 pleckstrin homology domain containing, family A member 5
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PPL periplakin
PTX3 pentraxin 3, long
RGS10 regulator of G-protein signaling 10
RIOK3 RIO kinase 3
RNASET2 ribonuclease T2
RND3 Rho family GTPase 3
RNMT RNA (guanine-7-) methyltransferase
RPL22 ribosomal protein L22
RPL36 ribosomal protein L36
RSL1D1 ribosomal L1 domain containing 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SERINC1 serine incorporator 1
SOD2 superoxide dismutase 2, mitochondrial
SPATA20 spermatogenesis associated 20
SQSTM1 sequestosome 1
SSPN sarcospan
SST somatostatin
STMN2 stathmin 2
TFPI2 tissue factor pathway inhibitor 2
TIMP2 TIMP metallopeptidase inhibitor 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast)
TPM1 tropomyosin 1 (alpha)
TPP1 tripeptidyl peptidase I
TRAF3IP2 TRAF3 interacting protein 2
VAT1 vesicle amine transport 1
ZNF277 zinc finger protein 277
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
AGTR1 angiotensin II receptor, type 1
AKAP7 A kinase (PRKA) anchor protein 7
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
BCHE butyrylcholinesterase
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CCNA2 cyclin A2
CCNF cyclin F
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDC7 cell division cycle 7
CDCA3 cell division cycle associated 3
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CEP55 centrosomal protein 55kDa
CIT citron rho-interacting serine/threonine kinase
CKLF chemokine-like factor
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL9 chemokine (C-X-C motif) ligand 9
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DBF4 DBF4 zinc finger
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DDIT4 DNA-damage-inducible transcript 4
DEPDC1 DEP domain containing 1
DHCR24 24-dehydrocholesterol reductase
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
EBP emopamil binding protein (sterol isomerase)
EXO1 exonuclease 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FEN1 flap structure-specific endonuclease 1
FOXM1 forkhead box M1
GAS1 growth arrest-specific 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
H2AFX H2A histone family, member X
HACD3 3-hydroxyacyl-CoA dehydratase 3
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOXC6 homeobox C6
ICMT isoprenylcysteine carboxyl methyltransferase
IDI1 isopentenyl-diphosphate delta isomerase 1
IGL immunoglobulin lambda locus
INSIG1 insulin induced gene 1
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LMNB1 lamin B1
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
METTL7A methyltransferase like 7A
MKI67 marker of proliferation Ki-67
MRPS16 mitochondrial ribosomal protein S16
MSMO1 methylsterol monooxygenase 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYCBP MYC binding protein
NCAPG2 non-SMC condensin II complex, subunit G2
NEK2 NIMA-related kinase 2
NET1 neuroepithelial cell transforming 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1
NUSAP1 nucleolar and spindle associated protein 1
PBK PDZ binding kinase
PDIA4 protein disulfide isomerase family A, member 4
PLK1 polo-like kinase 1
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PON2 paraoxonase 2
POSTN periostin, osteoblast specific factor
PTTG1 pituitary tumor-transforming 1
RAD51C RAD51 paralog C
RFC5 replication factor C (activator 1) 5, 36.5kDa
RPA3 replication protein A3, 14kDa
RRM2 ribonucleotide reductase M2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SMC2 structural maintenance of chromosomes 2
SMC4 structural maintenance of chromosomes 4
SPAG5 sperm associated antigen 5
SRSF7 serine/arginine-rich splicing factor 7
STEAP1 six transmembrane epithelial antigen of the prostate 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TIMELESS timeless circadian clock
TK1 thymidine kinase 1, soluble
TMEM194A transmembrane protein 194A
TMPO thymopoietin
TNC tenascin C
TOP2A topoisomerase (DNA) II alpha 170kDa
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TPX2 TPX2, microtubule-associated
TSPAN13 tetraspanin 13
TUBG1 tubulin, gamma 1
TWF1 twinfilin actin binding protein 1
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
WHSC1 Wolf-Hirschhorn syndrome candidate 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWINT ZW10 interacting kinetochore protein