BRD-A45498368_WYE-125132_HME1_24_h_0.12_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

147 genes differentially expressed following the BRD-A45498368_WYE-125132_HME1_24_h_0.12_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
AHNAK2 AHNAK nucleoprotein 2
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
BHLHE41 basic helix-loop-helix family, member e41
C14ORF132 chromosome 14 open reading frame 132
CD14 CD14 molecule
CD163 CD163 molecule
CDK5RAP3 CDK5 regulatory subunit associated protein 3
COL18A1 collagen, type XVIII, alpha 1
CRABP1 cellular retinoic acid binding protein 1
CRYAB crystallin, alpha B
CUTA cutA divalent cation tolerance homolog (E. coli)
CXCL8 chemokine (C-X-C motif) ligand 8
EFNA1 ephrin-A1
EGFR epidermal growth factor receptor
ENO2 enolase 2 (gamma, neuronal)
EPB41L3 erythrocyte membrane protein band 4.1-like 3
ETHE1 ethylmalonic encephalopathy 1
F13A1 coagulation factor XIII, A1 polypeptide
FBN2 fibrillin 2
FOXO1 forkhead box O1
FXR1 fragile X mental retardation, autosomal homolog 1
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
HRH1 histamine receptor H1
HSPA2 heat shock 70kDa protein 2
IFI6 interferon, alpha-inducible protein 6
IGF1R insulin-like growth factor 1 receptor
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL1B interleukin 1, beta
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITGB1BP1 integrin beta 1 binding protein 1
KLHL21 kelch-like family member 21
LAMA3 laminin, alpha 3
LAMC2 laminin, gamma 2
LYST lysosomal trafficking regulator
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MFAP5 microfibrillar associated protein 5
MINK1 misshapen-like kinase 1
MMP1 matrix metallopeptidase 1
NOV nephroblastoma overexpressed
NPC1 Niemann-Pick disease, type C1
NRCAM neuronal cell adhesion molecule
NUPR1 nuclear protein, transcriptional regulator, 1
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PHKG2 phosphorylase kinase, gamma 2 (testis)
PLEKHA5 pleckstrin homology domain containing, family A member 5
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PRAME preferentially expressed antigen in melanoma
PTX3 pentraxin 3, long
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RGS3 regulator of G-protein signaling 3
RIOK3 RIO kinase 3
RND3 Rho family GTPase 3
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SPP1 secreted phosphoprotein 1
SQSTM1 sequestosome 1
STAB1 stabilin 1
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TPP1 tripeptidyl peptidase I
VAT1 vesicle amine transport 1
WDR7 WD repeat domain 7
ZIC1 Zic family member 1

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AQP3 aquaporin 3 (Gill blood group)
AURKA aurora kinase A
AUTS2 autism susceptibility candidate 2
BIRC5 baculoviral IAP repeat containing 5
CCNA2 cyclin A2
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDC42 cell division cycle 42
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CEP55 centrosomal protein 55kDa
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
CXCL9 chemokine (C-X-C motif) ligand 9
DBF4 DBF4 zinc finger
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DDIT4 DNA-damage-inducible transcript 4
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EMP2 epithelial membrane protein 2
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FEN1 flap structure-specific endonuclease 1
GAS1 growth arrest-specific 1
GATA3 GATA binding protein 3
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GTSE1 G-2 and S-phase expressed 1
GZMK granzyme K (granzyme 3; tryptase II)
H2AFX H2A histone family, member X
HIST1H2BG histone cluster 1, H2bg
HMGB1 high mobility group box 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IDI1 isopentenyl-diphosphate delta isomerase 1
INSIG1 insulin induced gene 1
ITM2A integral membrane protein 2A
KANK1 KN motif and ankyrin repeat domains 1
KIF20A kinesin family member 20A
LAMP5 lysosomal-associated membrane protein family, member 5
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MALL mal, T-cell differentiation protein-like
MAP7 microtubule-associated protein 7
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MELK maternal embryonic leucine zipper kinase
METTL7A methyltransferase like 7A
MSMO1 methylsterol monooxygenase 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYCBP MYC binding protein
NBL1 neuroblastoma 1, DAN family BMP antagonist
NPY neuropeptide Y
PCNA proliferating cell nuclear antigen
PLAC8 placenta-specific 8
PLK1 polo-like kinase 1
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRPF4 pre-mRNA processing factor 4
PTTG1 pituitary tumor-transforming 1
RACGAP1 Rac GTPase activating protein 1
RFC5 replication factor C (activator 1) 5, 36.5kDa
RRM2 ribonucleotide reductase M2
SC5D sterol-C5-desaturase
SESN1 sestrin 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC38A1 solute carrier family 38, member 1
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SQLE squalene epoxidase
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TFAM transcription factor A, mitochondrial
THAP11 THAP domain containing 11
TMEM194A transmembrane protein 194A
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TSPAN13 tetraspanin 13
TSPYL5 TSPY-like 5
UBE2C ubiquitin-conjugating enzyme E2C
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)