BRD-A45498368_WYE-125132_HEPG2_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

178 genes differentially expressed following the BRD-A45498368_WYE-125132_HEPG2_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAK1 AP2 associated kinase 1
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABHD2 abhydrolase domain containing 2
ADAM10 ADAM metallopeptidase domain 10
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ANXA5 annexin A5
BBX bobby sox homolog (Drosophila)
C5AR1 complement component 5a receptor 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CRISP3 cysteine-rich secretory protein 3
CST1 cystatin SN
CTGF connective tissue growth factor
CYR61 cysteine-rich, angiogenic inducer, 61
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DST dystonin
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
ERBB3 erb-b2 receptor tyrosine kinase 3
FHL2 four and a half LIM domains 2
G0S2 G0/G1 switch 2
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
HBEGF heparin-binding EGF-like growth factor
IGFBP1 insulin-like growth factor binding protein 1
IGFBP4 insulin-like growth factor binding protein 4
INPP1 inositol polyphosphate-1-phosphatase
IRS2 insulin receptor substrate 2
KCTD12 potassium channel tetramerization domain containing 12
KLF9 Kruppel-like factor 9
KRT7 keratin 7, type II
LAMB3 laminin, beta 3
LAMC2 laminin, gamma 2
LAPTM5 lysosomal protein transmembrane 5
LCN2 lipocalin 2
LEF1 lymphoid enhancer-binding factor 1
LGALS8 lectin, galactoside-binding, soluble, 8
LRP10 low density lipoprotein receptor-related protein 10
LXN latexin
MACF1 microtubule-actin crosslinking factor 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPK13 mitogen-activated protein kinase 13
MARCKS myristoylated alanine-rich protein kinase C substrate
MBNL1 muscleblind-like splicing regulator 1
MGLL monoglyceride lipase
MIR22HG MIR22 host gene
MMP7 matrix metallopeptidase 7
MVP major vault protein
MYRF myelin regulatory factor
N4BP2L2 NEDD4 binding protein 2-like 2
NCF2 neutrophil cytosolic factor 2
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NPDC1 neural proliferation, differentiation and control, 1
NPIPB3 nuclear pore complex interacting protein family, member B3
NPTX2 neuronal pentraxin II
NR4A2 nuclear receptor subfamily 4, group A, member 2
OPHN1 oligophrenin 1
PAWR PRKC, apoptosis, WT1, regulator
PDZK1IP1 PDZK1 interacting protein 1
PLAT plasminogen activator, tissue
PLBD1 phospholipase B domain containing 1
PNMAL1 paraneoplastic Ma antigen family-like 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
QPCT glutaminyl-peptide cyclotransferase
RBP1 retinol binding protein 1, cellular
RGS5 regulator of G-protein signaling 5
RIN2 Ras and Rab interactor 2
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RSRP1 arginine/serine-rich protein 1
S100P S100 calcium binding protein P
SAMD4A sterile alpha motif domain containing 4A
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SMAD3 SMAD family member 3
SPON2 spondin 2, extracellular matrix protein
SPTBN1 spectrin, beta, non-erythrocytic 1
SQSTM1 sequestosome 1
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TACSTD2 tumor-associated calcium signal transducer 2
TBL1X transducin (beta)-like 1X-linked
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGM2 transglutaminase 2
TIMP3 TIMP metallopeptidase inhibitor 3
TM4SF1 transmembrane 4 L six family member 1
TMC5 transmembrane channel-like 5
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRIM44 tripartite motif containing 44
TRIM8 tripartite motif containing 8
UBXN7 UBX domain protein 7
VNN1 vanin 1
WT1 Wilms tumor 1

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
AK4 adenylate kinase 4
ALOX15B arachidonate 15-lipoxygenase, type B
BIRC5 baculoviral IAP repeat containing 5
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CCNA2 cyclin A2
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDK1 cyclin-dependent kinase 1
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CETN2 centrin, EF-hand protein, 2
CHEK2 checkpoint kinase 2
COL3A1 collagen, type III, alpha 1
CSTA cystatin A (stefin A)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL9 chemokine (C-X-C motif) ligand 9
CYB5A cytochrome b5 type A (microsomal)
CYCS cytochrome c, somatic
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DCK deoxycytidine kinase
DCXR dicarbonyl/L-xylulose reductase
DDIT4 DNA-damage-inducible transcript 4
DHCR7 7-dehydrocholesterol reductase
DHRS2 dehydrogenase/reductase (SDR family) member 2
EBP emopamil binding protein (sterol isomerase)
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FOXM1 forkhead box M1
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GINS1 GINS complex subunit 1 (Psf1 homolog)
GJA1 gap junction protein, alpha 1, 43kDa
GLUL glutamate-ammonia ligase
H2AFX H2A histone family, member X
HILPDA hypoxia inducible lipid droplet-associated
HIST1H4C histone cluster 1, H4c
HMGB2 high mobility group box 2
HMGB3 high mobility group box 3
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HRSP12 heat-responsive protein 12
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDI1 isopentenyl-diphosphate delta isomerase 1
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IL13RA2 interleukin 13 receptor, alpha 2
JCHAIN joining chain of multimeric IgA and IgM
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LMNB1 lamin B1
LTF lactotransferrin
LYZ lysozyme
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCAM melanoma cell adhesion molecule
MELK maternal embryonic leucine zipper kinase
MSMO1 methylsterol monooxygenase 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NEK2 NIMA-related kinase 2
PBK PDZ binding kinase
PHGDH phosphoglycerate dehydrogenase
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRC1 protein regulator of cytokinesis 1
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2
PTTG1 pituitary tumor-transforming 1
PXMP2 peroxisomal membrane protein 2, 22kDa
RRM2 ribonucleotide reductase M2
SESN1 sestrin 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC2A4RG SLC2A4 regulator
SQLE squalene epoxidase
STRA13 stimulated by retinoic acid 13
SUB1 SUB1 homolog (S. cerevisiae)
TDO2 tryptophan 2,3-dioxygenase
TK1 thymidine kinase 1, soluble
TMEM97 transmembrane protein 97
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIM2 tripartite motif containing 2
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S