BRD-A45498368_WYE-125132_HEPG2_24_h_0.12_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

152 genes differentially expressed following the BRD-A45498368_WYE-125132_HEPG2_24_h_0.12_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ACTN1 actinin, alpha 1
AKAP12 A kinase (PRKA) anchor protein 12
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
BBX bobby sox homolog (Drosophila)
BGN biglycan
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
COL11A1 collagen, type XI, alpha 1
CRISP3 cysteine-rich secretory protein 3
CTGF connective tissue growth factor
CXCL8 chemokine (C-X-C motif) ligand 8
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EGR3 early growth response 3
FLNA filamin A, alpha
FN1 fibronectin 1
GBP2 guanylate binding protein 2, interferon-inducible
GPATCH8 G patch domain containing 8
HAPLN1 hyaluronan and proteoglycan link protein 1
IGFBP1 insulin-like growth factor binding protein 1
INHBA inhibin, beta A
IRS2 insulin receptor substrate 2
ITGA10 integrin, alpha 10
ITGB5 integrin, beta 5
KCTD12 potassium channel tetramerization domain containing 12
KLF9 Kruppel-like factor 9
KRT18 keratin 18, type I
KRT7 keratin 7, type II
LEPROT leptin receptor overlapping transcript
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAMLD1 mastermind-like domain containing 1
MBNL1 muscleblind-like splicing regulator 1
MERTK MER proto-oncogene, tyrosine kinase
MFAP5 microfibrillar associated protein 5
MGLL monoglyceride lipase
MGP matrix Gla protein
MMP7 matrix metallopeptidase 7
MT1X metallothionein 1X
NPIPB3 nuclear pore complex interacting protein family, member B3
NR1D2 nuclear receptor subfamily 1, group D, member 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
PAWR PRKC, apoptosis, WT1, regulator
PDLIM5 PDZ and LIM domain 5
PFKL phosphofructokinase, liver
PIGP phosphatidylinositol glycan anchor biosynthesis, class P
PLAT plasminogen activator, tissue
PSCA prostate stem cell antigen
PYGB phosphorylase, glycogen; brain
RGS4 regulator of G-protein signaling 4
RGS5 regulator of G-protein signaling 5
RSRP1 arginine/serine-rich protein 1
S100P S100 calcium binding protein P
SAMD4A sterile alpha motif domain containing 4A
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SMAD3 SMAD family member 3
SNRPE small nuclear ribonucleoprotein polypeptide E
SPTAN1 spectrin, alpha, non-erythrocytic 1
SQSTM1 sequestosome 1
SRSF11 serine/arginine-rich splicing factor 11
THBS2 thrombospondin 2
TJP2 tight junction protein 2
TLR4 toll-like receptor 4
TM4SF4 transmembrane 4 L six family member 4
TPM1 tropomyosin 1 (alpha)
TPP1 tripeptidyl peptidase I
TXNIP thioredoxin interacting protein
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C
VAT1 vesicle amine transport 1
VCL vinculin
WDR45 WD repeat domain 45

decreased expression

Symbol Name
AIM1 absent in melanoma 1
AUTS2 autism susceptibility candidate 2
BACE2 beta-site APP-cleaving enzyme 2
BIRC5 baculoviral IAP repeat containing 5
C1S complement component 1, s subcomponent
C3ORF14 chromosome 3 open reading frame 14
C8ORF4 chromosome 8 open reading frame 4
CA12 carbonic anhydrase XII
CCNA2 cyclin A2
CDC25A cell division cycle 25A
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CETN2 centrin, EF-hand protein, 2
CSTA cystatin A (stefin A)
CXCL13 chemokine (C-X-C motif) ligand 13
CYB5A cytochrome b5 type A (microsomal)
DACH1 dachshund family transcription factor 1
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
EBP emopamil binding protein (sterol isomerase)
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
FEN1 flap structure-specific endonuclease 1
FST follistatin
FTH1 ferritin, heavy polypeptide 1
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
H2AFX H2A histone family, member X
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMGN3 high mobility group nucleosomal binding domain 3
HMOX1 heme oxygenase 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IDI1 isopentenyl-diphosphate delta isomerase 1
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
LAMA3 laminin, alpha 3
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MB myoglobin
MDFIC MyoD family inhibitor domain containing
MEIS2 Meis homeobox 2
MREG melanoregulin
MSMO1 methylsterol monooxygenase 1
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NEB nebulin
NEFH neurofilament, heavy polypeptide
NEK2 NIMA-related kinase 2
NR2F1 nuclear receptor subfamily 2, group F, member 1
NREP neuronal regeneration related protein
P3H2 prolyl 3-hydroxylase 2
PHGDH phosphoglycerate dehydrogenase
PI3 peptidase inhibitor 3, skin-derived
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRDX6 peroxiredoxin 6
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RAD51C RAD51 paralog C
RND3 Rho family GTPase 3
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SHB Src homology 2 domain containing adaptor protein B
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SMYD3 SET and MYND domain containing 3
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPTSSA serine palmitoyltransferase, small subunit A
SQLE squalene epoxidase
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
TOB1 transducer of ERBB2, 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TSPAN8 tetraspanin 8
TUBA4A tubulin, alpha 4a
UGDH UDP-glucose 6-dehydrogenase
WNT5A wingless-type MMTV integration site family, member 5A