BRD-A45498368_WYE-125132_HEPG2_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

93 genes differentially expressed following the BRD-A45498368_WYE-125132_HEPG2_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRE5 adhesion G protein-coupled receptor E5
AGTR1 angiotensin II receptor, type 1
AMIGO2 adhesion molecule with Ig-like domain 2
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
CD24 CD24 molecule
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CRISP3 cysteine-rich secretory protein 3
CST7 cystatin F (leukocystatin)
CTGF connective tissue growth factor
CYR61 cysteine-rich, angiogenic inducer, 61
DUSP6 dual specificity phosphatase 6
EPHB2 EPH receptor B2
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
GPRC5A G protein-coupled receptor, class C, group 5, member A
GULP1 GULP, engulfment adaptor PTB domain containing 1
IGHM immunoglobulin heavy constant mu
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
IRS2 insulin receptor substrate 2
ITGA6 integrin, alpha 6
ITGB5 integrin, beta 5
KLF9 Kruppel-like factor 9
KLHL21 kelch-like family member 21
LCN2 lipocalin 2
LDHB lactate dehydrogenase B
LEF1 lymphoid enhancer-binding factor 1
LITAF lipopolysaccharide-induced TNF factor
MEIS1 Meis homeobox 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
QPCT glutaminyl-peptide cyclotransferase
REG1A regenerating islet-derived 1 alpha
RNASE3 ribonuclease, RNase A family, 3
S100P S100 calcium binding protein P
SYNJ2 synaptojanin 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TMPRSS2 transmembrane protease, serine 2
TSPAN8 tetraspanin 8
VCL vinculin

decreased expression

Symbol Name
AK4 adenylate kinase 4
BID BH3 interacting domain death agonist
BIRC5 baculoviral IAP repeat containing 5
C1QA complement component 1, q subcomponent, A chain
CA2 carbonic anhydrase II
CHEK2 checkpoint kinase 2
CLIC2 chloride intracellular channel 2
COL1A2 collagen, type I, alpha 2
CTSC cathepsin C
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL14 chemokine (C-X-C motif) ligand 14
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHCR24 24-dehydrocholesterol reductase
DIO1 deiodinase, iodothyronine, type I
DSP desmoplakin
DTNA dystrobrevin, alpha
EBP emopamil binding protein (sterol isomerase)
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF5 eukaryotic translation initiation factor 5
FTH1 ferritin, heavy polypeptide 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GLUL glutamate-ammonia ligase
HMOX1 heme oxygenase 1
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IL17RB interleukin 17 receptor B
IL1RN interleukin 1 receptor antagonist
KRT19 keratin 19, type I
LAMP3 lysosomal-associated membrane protein 3
LAP3 leucine aminopeptidase 3
METTL7A methyltransferase like 7A
MSMO1 methylsterol monooxygenase 1
NQO1 NAD(P)H dehydrogenase, quinone 1
PHGDH phosphoglycerate dehydrogenase
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRDX4 peroxiredoxin 4
RAD23B RAD23 homolog B (S. cerevisiae)
S100A8 S100 calcium binding protein A8
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
SQLE squalene epoxidase
TSPAN7 tetraspanin 7
TSPYL5 TSPY-like 5
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
ZWINT ZW10 interacting kinetochore protein