BRD-A45498368_WYE-125132_HCC515_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

175 genes differentially expressed following the BRD-A45498368_WYE-125132_HCC515_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACVR1 activin A receptor, type I
ADRB2 adrenoceptor beta 2, surface
AHNAK2 AHNAK nucleoprotein 2
AMDHD2 amidohydrolase domain containing 2
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
BCAM basal cell adhesion molecule (Lutheran blood group)
BEX1 brain expressed, X-linked 1
C6ORF48 chromosome 6 open reading frame 48
CAMLG calcium modulating ligand
CD52 CD52 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CIRBP cold inducible RNA binding protein
COL11A1 collagen, type XI, alpha 1
CST1 cystatin SN
CTSA cathepsin A
CTSB cathepsin B
CTSH cathepsin H
CTSL cathepsin L
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
EIF4B eukaryotic translation initiation factor 4B
FAM134A family with sequence similarity 134, member A
GAA glucosidase, alpha; acid
GABARAPL1 GABA(A) receptor-associated protein like 1
GAS6 growth arrest-specific 6
GNPDA1 glucosamine-6-phosphate deaminase 1
GOLGA8H golgin A8 family, member H
GRN granulin
HBP1 HMG-box transcription factor 1
HEBP1 heme binding protein 1
HMOX1 heme oxygenase 1
HPSE heparanase
IDS iduronate 2-sulfatase
IFI44 interferon-induced protein 44
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGBP1 immunoglobulin (CD79A) binding protein 1
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
KRT7 keratin 7, type II
LAMP2 lysosomal-associated membrane protein 2
LDOC1 leucine zipper, down-regulated in cancer 1
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS3 lectin, galactoside-binding, soluble, 3
MME membrane metallo-endopeptidase
MTMR11 myotubularin related protein 11
MTSS1 metastasis suppressor 1
MXI1 MAX interactor 1, dimerization protein
MXRA5 matrix-remodelling associated 5
NCK1 NCK adaptor protein 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEU1 sialidase 1 (lysosomal sialidase)
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
NPC1 Niemann-Pick disease, type C1
NPC2 Niemann-Pick disease, type C2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NUPR1 nuclear protein, transcriptional regulator, 1
ORAI3 ORAI calcium release-activated calcium modulator 3
PCP4 Purkinje cell protein 4
PDGFC platelet derived growth factor C
PDGFD platelet derived growth factor D
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
POSTN periostin, osteoblast specific factor
RAB31 RAB31, member RAS oncogene family
RAP1GAP RAP1 GTPase activating protein
RPL31 ribosomal protein L31
RPS4Y1 ribosomal protein S4, Y-linked 1
RSRP1 arginine/serine-rich protein 1
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
SAT1 spermidine/spermine N1-acetyltransferase 1
SCARB2 scavenger receptor class B, member 2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SDC4 syndecan 4
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFTPB surfactant protein B
SLC16A6 solute carrier family 16, member 6
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TCTA T-cell leukemia translocation altered
TIMP3 TIMP metallopeptidase inhibitor 3
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPP1 tripeptidyl peptidase I
TSC22D3 TSC22 domain family, member 3
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
AREG amphiregulin
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BIRC5 baculoviral IAP repeat containing 5
BOP1 block of proliferation 1
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CCND2 cyclin D2
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDC7 cell division cycle 7
CDK1 cyclin-dependent kinase 1
CENPU centromere protein U
CKAP4 cytoskeleton-associated protein 4
CSRP2 cysteine and glycine-rich protein 2
CSTA cystatin A (stefin A)
DDIT4 DNA-damage-inducible transcript 4
DLD dihydrolipoamide dehydrogenase
DONSON downstream neighbor of SON
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DYNLT1 dynein, light chain, Tctex-type 1
EED embryonic ectoderm development
EIF4E eukaryotic translation initiation factor 4E
EREG epiregulin
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
H2AFX H2A histone family, member X
HELLS helicase, lymphoid-specific
HILPDA hypoxia inducible lipid droplet-associated
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HSPH1 heat shock 105kDa/110kDa protein 1
ICMT isoprenylcysteine carboxyl methyltransferase
IGFBP3 insulin-like growth factor binding protein 3
ITM2A integral membrane protein 2A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LTF lactotransferrin
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MSH2 mutS homolog 2
MSX1 msh homeobox 1
MYCBP MYC binding protein
NCAPG2 non-SMC condensin II complex, subunit G2
NES nestin
NPY1R neuropeptide Y receptor Y1
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PCOLCE2 procollagen C-endopeptidase enhancer 2
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PGK1 phosphoglycerate kinase 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PSPH phosphoserine phosphatase
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
RANBP1 RAN binding protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SPRR1A small proline-rich protein 1A
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TFRC transferrin receptor
TIMELESS timeless circadian clock
TNC tenascin C
TSPAN13 tetraspanin 13
TSPAN8 tetraspanin 8
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1
VRK1 vaccinia related kinase 1
ZWINT ZW10 interacting kinetochore protein