BRD-A45498368_WYE-125132_HCC515_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

224 genes differentially expressed following the BRD-A45498368_WYE-125132_HCC515_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACVR1 activin A receptor, type I
AMDHD2 amidohydrolase domain containing 2
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1
BPIFA1 BPI fold containing family A, member 1
C5AR1 complement component 5a receptor 1
C6ORF48 chromosome 6 open reading frame 48
CAMLG calcium modulating ligand
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
COL11A1 collagen, type XI, alpha 1
CORO1B coronin, actin binding protein, 1B
CREBL2 cAMP responsive element binding protein-like 2
CRISP3 cysteine-rich secretory protein 3
CSNK2A2 casein kinase 2, alpha prime polypeptide
CSTB cystatin B (stefin B)
CTSA cathepsin A
CTSB cathepsin B
CTSH cathepsin H
CTSL cathepsin L
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DPP4 dipeptidyl-peptidase 4
EIF4B eukaryotic translation initiation factor 4B
F13A1 coagulation factor XIII, A1 polypeptide
FAM50A family with sequence similarity 50, member A
FAXDC2 fatty acid hydroxylase domain containing 2
FOLR1 folate receptor 1 (adult)
FOXO4 forkhead box O4
FXR1 fragile X mental retardation, autosomal homolog 1
GAB2 GRB2-associated binding protein 2
GABARAP GABA(A) receptor-associated protein
GABARAPL1 GABA(A) receptor-associated protein like 1
GATAD1 GATA zinc finger domain containing 1
GDF15 growth differentiation factor 15
GNPDA1 glucosamine-6-phosphate deaminase 1
GPNMB glycoprotein (transmembrane) nmb
GRN granulin
GSN gelsolin
GTF2IRD1 GTF2I repeat domain containing 1
HBP1 HMG-box transcription factor 1
HDAC5 histone deacetylase 5
HMOX1 heme oxygenase 1
HS1BP3 HCLS1 binding protein 3
ICAM1 intercellular adhesion molecule 1
IDS iduronate 2-sulfatase
IGBP1 immunoglobulin (CD79A) binding protein 1
KLHL24 kelch-like family member 24
LAMP2 lysosomal-associated membrane protein 2
LCN2 lipocalin 2
LDOC1 leucine zipper, down-regulated in cancer 1
LETMD1 LETM1 domain containing 1
LGALS3 lectin, galactoside-binding, soluble, 3
LOC399491
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAOA monoamine oxidase A
MAP2K5 mitogen-activated protein kinase kinase 5
MGST3 microsomal glutathione S-transferase 3
MTSS1 metastasis suppressor 1
MXI1 MAX interactor 1, dimerization protein
N4BP2L2 NEDD4 binding protein 2-like 2
NAV2 neuron navigator 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEU1 sialidase 1 (lysosomal sialidase)
NPC1 Niemann-Pick disease, type C1
NPC2 Niemann-Pick disease, type C2
NUPR1 nuclear protein, transcriptional regulator, 1
ORAI3 ORAI calcium release-activated calcium modulator 3
PDGFC platelet derived growth factor C
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PKD1P1 polycystic kidney disease 1 (autosomal dominant) pseudogene 1
PNRC1 proline-rich nuclear receptor coactivator 1
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PPAP2B phosphatidic acid phosphatase type 2B
PSAP prosaposin
RAP1GAP RAP1 GTPase activating protein
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RRAGD Ras-related GTP binding D
RSL24D1 ribosomal L24 domain containing 1
RSRP1 arginine/serine-rich protein 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SQSTM1 sequestosome 1
THBS4 thrombospondin 4
TPP1 tripeptidyl peptidase I
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
VAT1 vesicle amine transport 1
VDAC1 voltage-dependent anion channel 1
ZNF277 zinc finger protein 277
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ALB albumin
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ARHGAP29 Rho GTPase activating protein 29
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CA1 carbonic anhydrase I
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CARD10 caspase recruitment domain family, member 10
CASP7 caspase 7, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CCNB1 cyclin B1
CCNE2 cyclin E2
CCNF cyclin F
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDC7 cell division cycle 7
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CENPU centromere protein U
COL3A1 collagen, type III, alpha 1
CPE carboxypeptidase E
DHFR dihydrofolate reductase
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EREG epiregulin
EXO1 exonuclease 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP1 fatty acid binding protein 1, liver
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GBP1 guanylate binding protein 1, interferon-inducible
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPER1 G protein-coupled estrogen receptor 1
H2AFX H2A histone family, member X
HELLS helicase, lymphoid-specific
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGFBP3 insulin-like growth factor binding protein 3
IGHD immunoglobulin heavy constant delta
IGL immunoglobulin lambda locus
IL13RA2 interleukin 13 receptor, alpha 2
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
ITM2A integral membrane protein 2A
JCHAIN joining chain of multimeric IgA and IgM
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF18B kinesin family member 18B
KIF4A kinesin family member 4A
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT6B keratin 6B, type II
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LUM lumican
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MALL mal, T-cell differentiation protein-like
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MMP12 matrix metallopeptidase 12
MS4A12 membrane-spanning 4-domains, subfamily A, member 12
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NPY1R neuropeptide Y receptor Y1
NUP210 nucleoporin 210kDa
OIP5 Opa interacting protein 5
PBK PDZ binding kinase
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCNA proliferating cell nuclear antigen
PEG10 paternally expressed 10
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAC8 placenta-specific 8
PRC1 protein regulator of cytokinesis 1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKD3 protein kinase D3
PTHLH parathyroid hormone-like hormone
RAD51 RAD51 recombinase
RAD51AP1 RAD51 associated protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SEPHS1 selenophosphate synthetase 1
SHCBP1 SHC SH2-domain binding protein 1
SMC1A structural maintenance of chromosomes 1A
SPINK1 serine peptidase inhibitor, Kazal type 1
SRSF3 serine/arginine-rich splicing factor 3
SRSF7 serine/arginine-rich splicing factor 7
TACC3 transforming, acidic coiled-coil containing protein 3
TFDP1 transcription factor Dp-1
TFRC transferrin receptor
TIMELESS timeless circadian clock
TK1 thymidine kinase 1, soluble
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM176B transmembrane protein 176B
TMEM47 transmembrane protein 47
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIM14 tripartite motif containing 14
TRIP13 thyroid hormone receptor interactor 13
TSPAN13 tetraspanin 13
TSPAN8 tetraspanin 8
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
VRK1 vaccinia related kinase 1
ZWINT ZW10 interacting kinetochore protein