BRD-A45498368_WYE-125132_HCC515_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

133 genes differentially expressed following the BRD-A45498368_WYE-125132_HCC515_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
AHNAK2 AHNAK nucleoprotein 2
AMOTL2 angiomotin like 2
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
C6ORF48 chromosome 6 open reading frame 48
C9ORF3 chromosome 9 open reading frame 3
CAMLG calcium modulating ligand
CAST calpastatin
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CD9 CD9 molecule
CFD complement factor D (adipsin)
CLEC11A C-type lectin domain family 11, member A
CRIP1 cysteine-rich protein 1 (intestinal)
CTGF connective tissue growth factor
CYR61 cysteine-rich, angiogenic inducer, 61
DUSP6 dual specificity phosphatase 6
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EIF4B eukaryotic translation initiation factor 4B
EPHA3 EPH receptor A3
F13A1 coagulation factor XIII, A1 polypeptide
FOXO4 forkhead box O4
GAS6 growth arrest-specific 6
GATAD1 GATA zinc finger domain containing 1
GLTSCR2 glioma tumor suppressor candidate region gene 2
GOLGA8H golgin A8 family, member H
GPX3 glutathione peroxidase 3
HBP1 HMG-box transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HOXC6 homeobox C6
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IFI6 interferon, alpha-inducible protein 6
IGBP1 immunoglobulin (CD79A) binding protein 1
IGHD immunoglobulin heavy constant delta
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV3-20 immunoglobulin kappa variable 3-20
IGKV4-1 immunoglobulin kappa variable 4-1
IGLJ3 immunoglobulin lambda joining 3
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
JUP junction plakoglobin
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KLF6 Kruppel-like factor 6
KRT7 keratin 7, type II
LAMB2 laminin, beta 2 (laminin S)
LETMD1 LETM1 domain containing 1
LTBP3 latent transforming growth factor beta binding protein 3
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2
NCK1 NCK adaptor protein 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEFL neurofilament, light polypeptide
NPEPL1 aminopeptidase-like 1
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PDGFD platelet derived growth factor D
PDZK1IP1 PDZK1 interacting protein 1
PLAU plasminogen activator, urokinase
PLK2 polo-like kinase 2
PPL periplakin
RBM3 RNA binding motif (RNP1, RRM) protein 3
RIOK3 RIO kinase 3
RSRP1 arginine/serine-rich protein 1
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SH3BGRL SH3 domain binding glutamate-rich protein like
SKAP2 src kinase associated phosphoprotein 2
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD3 SMAD family member 3
SPAG9 sperm associated antigen 9
TCTA T-cell leukemia translocation altered
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TPP1 tripeptidyl peptidase I
TSC22D3 TSC22 domain family, member 3
TSPAN4 tetraspanin 4
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VCAN versican
YBX3 Y box binding protein 3

decreased expression

Symbol Name
ABHD6 abhydrolase domain containing 6
ADRB2 adrenoceptor beta 2, surface
AK4 adenylate kinase 4
ALB albumin
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
CA2 carbonic anhydrase II
CCL2 chemokine (C-C motif) ligand 2
CCNF cyclin F
CDC25A cell division cycle 25A
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
DDIT4 DNA-damage-inducible transcript 4
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP2 dual specificity phosphatase 2
EED embryonic ectoderm development
FABP1 fatty acid binding protein 1, liver
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FEN1 flap structure-specific endonuclease 1
G0S2 G0/G1 switch 2
GPC3 glypican 3
ICMT isoprenylcysteine carboxyl methyltransferase
IGFBP3 insulin-like growth factor binding protein 3
IL13RA2 interleukin 13 receptor, alpha 2
IL32 interleukin 32
ITM2A integral membrane protein 2A
LMNB1 lamin B1
LTF lactotransferrin
MAOB monoamine oxidase B
MCM10 minichromosome maintenance complex component 10
MMP12 matrix metallopeptidase 12
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYLK myosin light chain kinase
NES nestin
PLAC8 placenta-specific 8
PLCL2 phospholipase C-like 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PSPH phosphoserine phosphatase
RAD51 RAD51 recombinase
RGS2 regulator of G-protein signaling 2
RRM2 ribonucleotide reductase M2
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC43A3 solute carrier family 43, member 3
STK10 serine/threonine kinase 10
TF transferrin
TFRC transferrin receptor
TRIP13 thyroid hormone receptor interactor 13
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
USP6NL USP6 N-terminal like
XK X-linked Kx blood group